Ascorbic acid inhibits the migration of walker 256 carcinosarcoma cells

Wybieralska, Ewa; Koza, Monika; Sroka, Jolanta; Czyż, Jarosław; Madeja, Zbigniew

doi:10.2478/s11658-007-0040-z

Cited by 11 publications

(7 citation statements)

References 24 publications

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“…In contrast to directly influencing glucose metabolism to decrease ROS production, elimination of mitochondrial oxidative stress using an ROS scavenger appears to be an easier approach, as antioxidant agents/ROS scavengers are universally accessible. For example, the antioxidant ascorbic acid inhibits migration of Walker 256 carcinosarcoma cells [Wybieralska et al., ; Hogg, ].…”

Section: Drugs That Decrease Mitochondrially Derived Rosmentioning

confidence: 99%

Redox Regulation of Cancer Metastasis: Molecular Signaling and Therapeutic Opportunities

Yang

Zou

Huang

et al. 2014

Drug Development Research

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Cancer metastasis is the major cause of cancer-related mortality. Accumulated evidence has shown that high-metastasis potential cancer cells have more reactive oxygen species (ROS) accumulation compared with low-metastasis potential cancer cells. ROS can function as second messengers to regulate multiple cancer metastasis-related signaling pathways via reversible oxidative posttranslational modifications of cysteine in key redox-sensitive proteins, which leads to the structural and functional change of these proteins. Because ROS can promote cancer metastasis, therapeutic strategies aiming at inducing/reducing cellular ROS level or targeting redox sensors involved in metastasis hold great potential in developing new efficient approaches for anticancer therapy. In this review, we summarize recent findings on regulation of tumor metastasis by key redox sensors and describe the potential of targeting redox signaling pathways for cancer therapy.

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Section: Drugs That Decrease Mitochondrially Derived Rosmentioning

confidence: 99%

Redox Regulation of Cancer Metastasis: Molecular Signaling and Therapeutic Opportunities

Yang

Zou

Huang

et al. 2014

Drug Development Research

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“…It also has been shown to decrease MMP-9 synthesis induced by hydrogen peroxide in an in vitro chorioamniotic membrane model [58]. It is well known that MMPs are important for cancer metastasis and vitamin C has been proved to inhibit the migration of cancer cells independent of its antioxidant activity [59]. Therefore, it is likely that availability of vitamin C in the respiratory epithelium will inhibit the possible lethal mediator of inflammation, MMP-9, and reduce the extent of harm due to influenza virus infection.…”

Section: Story Of Vitamin C and Influenza Virus In The Laboratorymentioning

confidence: 99%

Combined inhalational and oral supplementation of ascorbic acid may prevent influenza pandemic emergency: A hypothesis

Banerjee

Kaul

2010

Nutrition

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Occurrence of influenza pandemics is a worldwide phenomenon and a significant cause of mortality and morbidity throughout the globe. It is due to mutations in the influenza virus genetic material creating antigenic drift of pathogenic viral proteins resulting in emergence of new influenza virus strains. Therefore, the vaccines available for prevention of influenza offer no protection against influenza pandemics caused by new virus strains. Moreover, the existing drugs used to combat influenza may be ineffective to treat influenza pandemics due to the emergence of drug resistance in the pandemic virus strain. Therefore, a working strategy must be developed to combat influenza pandemics. In this review we have addressed this problem and reviewed the published studies on ascorbic acid in the common cold and influenza and laboratory studies on the effect of ascorbic acid on influenza virus. We have also correlated the clinical and laboratory studies and developed a hypothesis to prevent influenza pandemics.

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“…Tumor development and progression consist of a series of complex processes involving multiple changes in gene expression [10]. Time-lapse analyses of Walker 256 carcinosarcoma cell migration showed that both the speed of movement and cell displacement are inhibited by ascorbic acid [14]. These results demonstrate that intact, unmodified ascorbic acid applied in physiologically relevant and nontoxic concentrations exerts an inhibitory effect on the migration of WC 256 carcinosarcoma cells, and that this may be one of the factors responsible for the anti-metastatic activity of ascorbic acid.…”

Section: Introductionmentioning

confidence: 99%

Proteomic analysis of tumor tissue in CT-26 implanted BALB/C mouse after treatment with ascorbic acid

Lee¹,

Lee²,

Park³

et al. 2012

Cellular and Molecular Biology Letters

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Abbreviations used: ATP -adenosine triphosphate; DTT -dithiothreitol; ECMextracellular matrix; GDT -guanosine diphosphate; LR -log ratio; MALDI TOF-MS/MS -Matrix-assisted laser-desorption ionization time-of-flight tandem mass spectroscopy; MMPs -matrix metalloproteinases; PAGE -polyacrylamide gel electrophoresis; PBSphosphate buffered solution; PCR -polymerase chain reaction; SDS -sodium dodecyl sulfate; TCA -trichloroacetic acid; TCTP -translationally controlled tumor protein; 2-DE -two-dimensional gel electrophoresis Abstract: Tumor establishment and penetration consists of a series of complex processes involving multiple changes in gene expression and protein modification. Proteome changes of tumor tissue were investigated after intraperitoneal administration of a high concentration of ascorbic acid in BALB/C mice implanted with CT-26 cancer cells using two-dimensional gel electrophoresis and mass spectrometry. Eighteen protein spots were identified whose expression was different between control and ascorbic acid treatment groups. In particular, eukaryotic translation initiation factor 3 subunit 1, nucleophosmin, latexin, actin-related protein 2/3 complex subunit 5, M2-type pyruvate kinase, vimentin, tumor protein translationally-controlled 1, RAS oncogene family Ran, plastin 3 precursor, ATPase, Rho GDT dissociation inhibitor β, and proteasome activator subunit 2 expression were quantitatively up-regulated. The increase in the level of these proteins was accompanied by an increase in mRNA level. The cytoskeleton protein actin, vimentin, and tumor protein translationally-controlled 1 showed quantitative expression profile differences. A change in actin cytoskeleton distribution, functionally relevant to the proteome result, was observed after treatment with ascorbic acid. These

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Ascorbic acid inhibits the migration of walker 256 carcinosarcoma cells

Cited by 11 publications

References 24 publications

Redox Regulation of Cancer Metastasis: Molecular Signaling and Therapeutic Opportunities

Redox Regulation of Cancer Metastasis: Molecular Signaling and Therapeutic Opportunities

Combined inhalational and oral supplementation of ascorbic acid may prevent influenza pandemic emergency: A hypothesis

Proteomic analysis of tumor tissue in CT-26 implanted BALB/C mouse after treatment with ascorbic acid

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