Ascorbic Acid Elimination in Humans after Intravenous Administration

Metabolic Clearance of the Antioxidant Ascorbic Acid in Surgical Patients1

“…A continuous infusion of ascorbic acid would probably reduce the daily doses for substitution but leads to a spontaneous oxidation of ascorbic acid during infusion. Pharmacokinetics of intravenous ascorbic acid bolus substitution is commonly studied in healthy subjects [9,23] but Vallance et al [24] demonstrated that an intravenous dose of 1 g of ascorbic acid every 4 h led to normal ascorbic acid plasma values within 24 h in patients with acute myocardial infarction. Long et al [11] showed comparable effects with a substitution of 3 g/day in critically ill patients.…”

Lifestyle behaviors and serum vitamin C in the Thai population in Bangkok Metropolitan

“…In addition, the high level of free radicals generated from cigarette smoking leads to high usage of vitamin C and might be involved (Eiserich et al, 1995[ 16 ]; Pelletier, 1997[ 39 ]; Alberg, 2002[ 1 ]). Moreover, it might be related to half-life of vitamin C in the body pool, which is approximately 16 days (Yung et al, 1978[ 61 ]; Hellman and Burn, 1958[ 21 ]). Awareness and knowledge of selecting the appropriate food to consume is an important factor to maintain adequate level of vitamin C in people.…”