Ascorbic acid catabolism in Bantu with hemosiderosis (scurvy)

Hankes, L. V.; Jansen, C. R.; Schmaeler, M.

doi:10.1016/0006-2944(74)90059-3

Cited by 9 publications

(3 citation statements)

References 17 publications

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“…The tissue of scorbutic guinea pigs has increased deposits of hemosiderin, a storage form of iron with limited bioavailability, while the more readily utilized ferritin fraction of liver iron is decreased (10). Vitamin C can reverse this process; South African Bantu, who may suffer from dietary iron overload from use of iron‐containing cooking utensils, are able to mobilize storage iron following dietary vitamin C supplementation (16,17). Vitamin C deficiency may also impair the enzymatic incorporation of iron into proto‐porphyrins during heme synthesis (18,19).…”

Section: Vitamin C‐associated Disorders In Dialysis Patientsmentioning

confidence: 99%

Is Vitamin C Intake too Low in Dialysis Patients?

Raimann

Levin

Craig

et al. 2012

Seminars in Dialysis

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Vitamin C has several well-established roles in physiology including synthesis of collagen, carnitine and epinephrine, absorption of dietary iron, and mobilization of storage iron for erythropoeisis. Loss of several of these functions explains the pathology of scurvy, where defective collagen synthesis and anemia are major symptoms. Vitamin C deficiency is very common in dialysis patients and may arise from dialytic vitamin C clearance, restricted intake of vitamin C-rich foods, and increased vitamin C catabolism in vivo from inflammation. In the dialysis population, greater vitamin C intake may be needed for optimal health. Relationships between intake, body distribution, inflammation, and dialytic losses are complex and need further study. Concern about vitamin C metabolism leading to accumulation of tissue oxalate has led to the recommendation that vitamin C intake equals, but not exceeds, the intake recommended for the general population. Vitamin C deficiency in dialysis patients may have clinical consequences; a study in Renal Research Institute clinics found an association with periodontal disease. Data also support a role for vitamin C in prevention of dialysis-related anemia. New research questions are proposed in this editorial, with a discussion of strategies to determine the optimal provision of vitamin C for CKD patients.

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Section: Vitamin C‐associated Disorders In Dialysis Patientsmentioning

confidence: 99%

Is Vitamin C Intake too Low in Dialysis Patients?

Raimann

Levin

Craig

et al. 2012

Seminars in Dialysis

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“…Greatly increased body Fe stores resulted in accelerated oxidative catabolism of ascorbic acid in Africa (Lynch et al 1967;Hankes et al 1974). Fe -vitamin C supplements were thought to damage DNA (Rehman et al 1998), but Yang et al (1999) found no lipid damage by vitamin C plus Fe supplements.…”

Section: Vitamin C -Food Interactionsmentioning

confidence: 99%

Stable isotope-labelled vitamin C as a probe for vitamin C absorption by human subjects

2004

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Factors affecting absorption of physiological doses of vitamin C in man have not been widely studied, partly because few suitable tools exist to distinguish recently absorbed vitamin C from endogenous vitamin. Stable isotope-labelled vitamin C provides such a tool. Fifteen healthy non-smoking subjects aged 26 -59 years were studied. Each received 30 mg L-[1-13 C]ascorbic acid orally on two occasions, 3 -4 weeks apart. The ascorbate was given alone or with Fe (100 mg as ferrous fumarate) or with red grape juice, which is rich in polyphenols. Blood was collected at frequent intervals for 1 h, and then each hour for a further 3 h. Total concentration of vitamin C was measured fluorometrically and its 13 C-isotope enrichment was measured by GC -MS after conversion to volatile trimethylsilyl esters. Peak plasma enrichment occurred within 25 -50 min. No kinetic variables were significantly altered by the iron fumarate supplement. Grape juice attenuated vitamin C absorption, reaching significance at the 20 min time point. There were weak correlations between isotope enrichment and body weight or endogenous ascorbate concentration. The increment in total plasma ascorbate was smaller if calculated from isotope enrichment than from vitamin C concentration increase. The dilution pool was much larger than the plasma ascorbate pool. Further studies are needed to resolve these paradoxes. Stable isotope-labelled ascorbate is potentially useful for measurement of vitamin C absorption by human subjects.

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“…Increased iron stores in tissue result in accelerated oxidative catabolism of ascorbic acid, contributing to ascorbic acid deficiency (14,15). L-Ascorbic acid (vitamin C) provides in vivo antioxidant protection primarily as an aqueous phase peroxyl and oxygen radical scavenger (16).…”

Section: Introductionmentioning

confidence: 99%