“…Co-supplementation of vitamin C and vitamin E immediately prior to an oral glucose challenge prevented the decrease in postprandial FMD responses that otherwise occurred with hyperglycemia [6]. However, maximal plasma vitamin E occurs~10 h following ingestion [32], whereas maximal plasma vitamin C occurs~60 min postingestion [33]. Thus, the maintenance of VEF following glucose ingestion in combination with supplementation of vitamins C and E [6] most likely reflects improvements in vitamin C status rather than vitamin E. Thus, our study provides the first direct evidence that dietary vitamin E supplementation, provided as γ-TmT, attenuates hyperglycemia-mediated impairments in VEF in healthy young men, at least partly by reducing lipid peroxidation.…”