Ascorbate as a source of reducing equivalents for the synthesis of aldosterone

Yanagibashi, Kazutoshi; Kobayashi, Yoshiharu; Hall, Peter F.

doi:10.1016/0006-291x(90)90529-v

Cited by 16 publications

(5 citation statements)

References 12 publications

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“…The sensitivity and specificity of the adrenocortical response to corticotrophin and, in the present context, the exquisite tissue specificity of the redox response, has been reported over 50 years, and the present results extend this series of studies (Sayers et al 1948, Kitabchi 1967, Chayen et al 1976, Hornsby et al 1985, Yanagibashi et al 1990. In demonstrating the corticotrophin-dependence of the transcription, expression and activity of MnSOD specifically in the zonae fasciculata/reticularis of the rat adrenal, the results presented here extend those of Suwa et al (2000), who showed induction of MnSOD transcription by corticotrophin; similar findings in bovine adrenocortical cells were reported by Chinn et al (2002).…”

Section: Discussionsupporting

confidence: 88%

“…Several attempts have been made to interpret this in functional terms (Kitabchi 1967, Hornsby et al 1985, Yanagibashi et al 1990. In this respect, the finding that manganese superoxide dismutase (MnSOD) gene transcription may be specifically enhanced by corticotrophin stimulation lends support to the concept of a physiological role (Suwa et al 2000).…”

Section: Introductionmentioning

confidence: 99%

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Manganese superoxide dismutase activity in the rat adrenal

Raza¹,

Okamoto²,

Takemori³

et al. 2005

Journal of Endocrinology

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In the light of studies suggesting that transcription of the gene coding for manganese superoxide dismutase (MnSOD) is induced by ACTH in the rat adrenal gland, northern blot analysis was used to determine its mRNA distribution. It was found that mRNA coding for MnSOD is primarily present in the inner zones of the rat adrenal cortex, and not the glomerulosa. To investigate the functional relationships between MnSOD activity and expression and adrenocortical function, adrenals and blood were taken from animals pretreated with corticotrophin or betamethasone (Betnesol), or subjected to a low-sodium diet. MnSOD activity in inner zone mitochondrial fractions was enhanced by corticotrophin and by a low-sodium diet, but suppressed by betamethasone. Apparent cytosolic MnSOD activity, total cytosolic MnSOD and CuZnMn-SOD, and glomerulosa mitochondrial MnSOD all were unaffected. Steroid assays showed a clear correlation between circulating corticosterone and inner zone mitochondrial MnSOD, but none between aldosterone and glomerulosa MnSOD.Immunoblot analysis of MnSOD showed two apparent isoforms, at approximately 25 kDa and 75 kDa. There was a partial relationship between expression of the 75 kDa isoform and MnSOD activity, in that it was induced by corticotrophin. However, there was also a slight induction with betamethasone, and a low-sodium diet had no effect. The 25 kDa MnSOD isoform was unaffected by the treatments. The results suggest that MnSOD may have a specific role in the steroidogenic function of the fasciculata/reticularis of the rat adrenal, but not in that of the glomerulosa.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Manganese superoxide dismutase activity in the rat adrenal

Raza¹,

Okamoto²,

Takemori³

et al. 2005

Journal of Endocrinology

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“…Pregnenolone is then transported into the endoplasmic reticulum (ER) in which it is oxidized into progesterone, and progesterone is then hydroxylated to form DOC (11-deoxycorticosterone). DOC is later transported back into the mitochondria, where it is further hydroxylated to form corticosterone (Yanagibashi et al, 1990). It is interesting to note that the sex steroid hormones are oxidized from progesterone in the ER.…”

Section: Corticosterone Synthesismentioning

confidence: 99%

“…The final step in the synthesis of both cortisol and corticosterone takes place in the mitochondria of the cells in question (Yanagibashi et al, 1990). Glucocorticoids are secreted in all vertebrates, but not in other life forms.…”

Section: Corticosterone Synthesismentioning

confidence: 99%

The information provided by the adrenal cortical steroids: A hypothesis

Weiss

Zahavi

2012

Journal of Theoretical Biology

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“…It acts as a true co-substrate for dopamine beta-monooxygenase for the biosynthesis of norepinephrine from dopamine in bovine granulosa cells (Dhariwal et al 1991). It also acts as a reducing agent for the synthesis of aldosterone in the adrenal gland (Yanagibashi et al 1990) and oxytocin in granulosa cells of corpus luteum (Luck and Jungclas 1988). Vitamin C regulates oxytocin secretion through direct interaction with catecholamines (Luck and Jungclas 1987).…”

Section: Biochemical Functionsmentioning

confidence: 99%

L-Ascorbic acid (vitamin C) supplementation to optimize health and reproduction in cattle

Ranjan

et al. 2012

Veterinary Quarterly

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Cattle can synthesize L-ascorbic acid (or Vitamin C) from either D-glucose or D-galactose through glucuronic acid pathway in the liver. L-Ascorbic acid present in cattle diet is almost totally destroyed by rumen microorganisms making them essentially dependent on its endogenous synthesis, which is assumed sufficient to meet the physiological requirement. Therefore, the role of vitamin C in cattle health and disease has remained widely overlooked. However, there is mounting evidence that the level of L-ascorbic acid in blood and other tissues decreases in association with stress and disease, and Vitamin C supplementation revealed favorable response as evident from early recovery. The present review is an attempt to summarize the existing literature pertaining to the physiological role of L-ascorbic acid and the scope of its supplementation in the prevention and treatment of diseases in cattle. It should be realized that the aqueous solution of vitamin C is highly acidic and subcutaneous or intramuscular administration may cause tissue irritation and inflammation, whereas the sodium ascorbate solution is less acidic and might be used for intramuscular administration.

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Ascorbate as a source of reducing equivalents for the synthesis of aldosterone

Cited by 16 publications

References 12 publications

Manganese superoxide dismutase activity in the rat adrenal

Manganese superoxide dismutase activity in the rat adrenal

The information provided by the adrenal cortical steroids: A hypothesis

L-Ascorbic acid (vitamin C) supplementation to optimize health and reproduction in cattle

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