The information provided by the adrenal cortical steroids: A hypothesis

Weiss, Meital; Zahavi, Alon

doi:10.1016/j.jtbi.2012.06.040

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…This perspective of secreted factors is based on the handicap principle, which suggests that signals provide reliable information relating to the state of the signaller (Zahavi, 1975;Zahavi and Zahavi, 1997). The handicap principle has been widely applied to signalling among multicellular organisms (Maynard Smith and Harper, 2003); however, only a handful of studies have attempted to apply it to intercellular signalling (Krakauer and Pagel, 1996;Zahavi and Perel, 2011;Weiss and Zahavi, 2012;Harris and Zahavi, 2013;Kölker, 2018) or to unicellular organisms (Nathon et al, 1995;Atzmony et al, 1997;Zahavi et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Applying the handicap principle to biofilms: condition‐dependent signalling inBacillus subtilismicrobial communities

Harris

Kolodkin‐Gal

2019

Environmental Microbiology

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Summary Bacteria in nature often reside in differentiated communities termed biofilms. These communities, which are composed of a number of functionally‐distinct cell types, are an interesting example of division of labour in microbes, and as such have been used as a system to study the evolution of cooperation. The structured population of the biofilm also plays a critical role in the persistence of infections, and biofouling of medical and industrial devices. Biofilm formation involves several stages of differentiation, which are mediated by extracellular factors secreted by cells composing the biofilm. The developmental model of biofilm formation describes this process mechanistically: specific subpopulations of cells synthesize signals within the biofilm, and promote the differentiation of other subpopulations. The handicap principle suggests that signals function because they provide reliable information regarding the state of the signaller; here, we apply the handicap principle to signalling among cells composing Bacillus subtilis biofilms, emphasizing the perspective of secreted factors as sources of information rather than solely as mediators of development. Such information could facilitate competition among phenotypically‐similar cells composing the biofilm, affecting local organizational patterns within defined subpopulations.

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Section: Introductionmentioning

confidence: 99%

Applying the handicap principle to biofilms: condition‐dependent signalling inBacillus subtilismicrobial communities

Harris

Kolodkin‐Gal

2019

Environmental Microbiology

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“…Amotz Zahavi spent the last years thinking about the role of hormones and physiology for signaling and how the design of these molecules could help enforce reliability in signals. Interestingly these ideas can be seen as the next boundary for signal selection (Weiss & Zahavi ; Zahavi & Perel, ). Importantly, this approach can be used in Darwinian medicine and for investigating the role of signaling in development of diseases such as cancer (Krakauer & Pagel, ).…”

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confidence: 99%