Ascending aortic aneurysm associated with aortic insufficiency due to Takayasu’s arteritis

Kalangos, Afksendiyos; Baldovinos, Ary; Beghetti, Maurice; Vala, Dominique; Faidutti, B

doi:10.1016/s0003-4975(99)00501-9

Cited by 20 publications

(14 citation statements)

References 4 publications

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“…1 Although its most common lesions are in the proximal segments of arteries arising from the transverse aortic arch, the incidence of aortic valve regurgitation (AR) in patients with Takayasu arteritis is between 13% and 25%, and AR is now considered an important risk factor for mortality in patients with this disease. [2][3][4][5][6][7][8][9][10][11] Furthermore, the most serious complication of aortic valve replacement (AVR) or aortic root replacement is detachment of the prosthetic valve or graft. 12 When patients with AR and aortic root dilatation are encountered, they must be treated carefully both surgically and medically.…”

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confidence: 99%

Surgical Treatment of Aortic Regurgitation due to Takayasu Arteritis

et al. 2005

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Background— The goal of this retrospective study was to determine the late outcome of surgical treatment for aortic valve regurgitation due to Takayasu arteritis and correlate it with evidence of inflammation on pathological examination. Methods and Results— Ninety consecutive patients who underwent surgery for aortic valve regurgitation due to Takayasu arteritis between 1979 and 2003 were studied. Intraoperative pathological specimens of the aortic wall from 69 patients were retrospectively examined for inflammation. Aortic valve replacement was performed in 63 patients (group A) and composite graft repair in 27 patients (group B). The aortic root diameter was 39.9±9.5 mm in group A and 54.4±13.6 mm in group B ( P <0.0001). Preoperative steroid therapy was performed in 40 patients (44.4%). Hospital mortality was 4.8% (3/63) in group A and 7.4% (2/27) in group B. The overall 15-year survival rate was 76.1%. Detachment of the valve or graft occurred in 11.1% (7/63) of group A and in 3.7% (1/27) of group B patients ( P =0.43). Late dilatation (>50 mm) of the residual ascending aorta occurred in 11.1% (7/63) of group A and in 3.7% (1/27) of group B patients ( P =0.43). Active inflammation was confirmed in intraoperative pathological specimens of 10 patients, and detachment of the valve or graft occurred in 4 of these patients. Univariate analysis of background variables revealed active inflammation to be a risk factor for detachment ( P =0.0001; risk ratio 55). Conclusions— Late dilatation of the ascending aorta after aortic valve replacement is a clinically important finding. Active inflammation could be related to valve or graft detachment.

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Surgical Treatment of Aortic Regurgitation due to Takayasu Arteritis

et al. 2005

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“…Isolated aortic aneurysms are rare in Takayasu disease [1]. Although the original reports of Takayasu aortitis are occlusive symptoms, more recent reports have emphasized the increased frequency of aneurysms [5]. Sheikhzadeh et al [6] described isolated aneurysms in 2% of their patients with Takayasu disease.…”

Section: Discussionmentioning

confidence: 99%

Isolated Aortic Aneurysm with Aortic Valve Regurgitation in Takayasu Disease

Hela¹,

Hak²,

Oussama³

et al. 2017

J Clin Exp Cardiolog

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Takayasu arteritis is a chronic inflammatory disease of the aorta, its main branches, and the pulmonary arteries. It is characterized by arterial stenoses and ischemic manifestations.Aneurismal dilatation of the ascending thoracic aorta associated with aortic regurgitation is rare in Takayasu disease.We report the cases of a 43-year-old woman with a Takayasu disease since 18 years, who presented a dyspnea and chest pain. Computed tmography and trans-thoracic echocardiography confirmed an ascending aortic aneurysm associated to a severe aortic insufficiency.The patient will underwent surgical replacement of the ascending aorta and the aortic valve.

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“…Hypertension occurs in 33-83% of patients mostly due to the involvement of the renal artery [3]. Aneurysmal dilatation of the aorta occurs in 2% to 26.7% of patients [4]. Aortic regurgitation can occur in association with dilatation of the ascending aorta and/or thickening of aortic valve leaflets.…”

Section: Discussionmentioning

confidence: 99%