Asbestos consumption, asbestos exposure and asbestos-related occupational diseases in Germany

Hagemeyer, Olaf; Otten, H.; Kraus, Thomas

doi:10.1007/s00420-006-0091-x

Cited by 43 publications

(28 citation statements)

References 17 publications

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“…A crude incidence rate of 10-13 per million may be estimated on the basis of the above data. In Germany there is no cancer registries covering all the national territory 18) . An incidence of 1,094 cases has been estimated for 2004 18) .The incidence rates could be about 13 cases per million.…”

Section: Incidencementioning

confidence: 99%

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Malignant Mesothelioma: Global Incidence and Relationship with Asbestos

2007

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Mesothelioma incidence varies markedly from one country to another. The highest annual crude incidence rates (about 30 cases per million) are observed in Australia, Belgium, and Great Britain. A lot of data indicate a relationship between mesothelioma and asbestos. The hot areas for mesothelioma exactly correspond to the sites of industries with high asbestos use, such as shipbuilding and asbestos-cement industry. However, in many countries with high asbestos consumption, mesothelioma incidence is low. The reasons for this fact are not clear. The latency periods elapsing between first exposure to asbestos and development of mesothelioma are mostly longer than 40 yr. An inverse relationship exists between intensity of asbestos exposure and length of the latency period. Mesothelioma generally develops after long-time exposures to asbestos. Some recent studies show that the risk increases with the duration of exposure. Possible co-factors in the pathogenesis of asbestos-related mesothelioma include genetic predisposition, diets poor in fruit and vegetables, viruses, immune impairment, recurrent serosal inflammation. The study of co-morbidity in mesothelioma could give an insight into the pathogenesis of the tumor. While a levelling-off in mesothelioma incidence has been registered in some countries, a worsening of the epidemic is predictable in large parts of the world.

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Section: Incidencementioning

confidence: 99%

“…In Germany there is no cancer registries covering all the national territory 18) . An incidence of 1,094 cases has been estimated for 2004 18) .The incidence rates could be about 13 cases per million. In Italy mesothelioma registries have only recently been extended to all national territory 42) .…”

Section: Incidencementioning

confidence: 99%

Malignant Mesothelioma: Global Incidence and Relationship with Asbestos

2007

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“…Asbestosis is a fibrotic reaction of the lung parenchyma due to asbestos fibers and is connected with an increased deposition of collagen in lung tissue [22]. In this context the levels of t-Hyp found in blood of previously asbestos-exposed workers, suffering from asbestosis, were elevated in comparison to the levels of t-Hyp found in blood of non-exposed controls and even dose-response relations were reported [23].…”

Section: Introductionmentioning

confidence: 97%

Simultaneous determination of 3-nitrotyrosine, tyrosine, hydroxyproline and proline in exhaled breath condensate by hydrophilic interaction liquid chromatography/electrospray ionization tandem mass spectrometry

Conventz

Musiol

Brodowsky

et al. 2007

Journal of Chromatography B

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“…Starting between 1997 and 2001 and ending in 2012 our follow-up was conducted in the midst of the epidemic of asbestos related diseases in Germany, which was provoked by excessive use of asbestos between 1955 and 1980 (West Germany) e.g., (East Germany) [35]. The peak of asbestos related diseases in Germany is expected within the next years and future follow-up analyses of this cohort will hopefully give more insight into the association of occupational exposure to asbestos and mortality causes; especially malignancies of the airways and the gastrointestinal tract.…”

Section: Latency Period Of Asbestos-related Diseasesmentioning

confidence: 99%

Occupational exposure to asbestos is associated with increased mortality in men recruited for a population-based study in Germany

Repp

Lorbeer

Ittermann

et al. 2015

Int J Occup Med Environ Health

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Objectives: Occupational exposure to asbestos is associated with increased mortality which, however, has not been thoroughly validated in a general population. We have aimed at exploring whether this association may be confirmed within a population-based setting after adjustment for confounders. Furthermore, the impact of tobacco consumption on the association between occupational exposure to asbestos and mortality is assessed. Material and Methods: We used data from 2072 (224 exposed) male participants of the Study of Health in Pomerania. Information on exposure to asbestos is based on a selfreport. Median follow-up time was 11.3 years. All-cause mortality and cause-specific mortality of exposed and non-exposed men were compared using mortality rate ratios, Kaplan-Meier analyses and multivariable Cox regression. Results: During the follow-up, 52 (23.2%) exposed and 320 (17.3%) non-exposed participants deceased. Exposed subjects had increased hazard ratios (HR) for all-cause mortality (HR=1.48, 95% CI: 1.1-2), benign lung disease mortality (HR=3, 95% CI: 1.18-7.62) and stomach cancer mortality (HR=4.59, 95% CI: 1.53-13.76). The duration of exposure (per 10 years) was associated with all-cause (HR=1.21, 95% CI: 1.07-1.36) and benign lung disease mortality (HR=1.68, 95% CI: 1.26-2.22). Smokers occupationally exposed to asbestos had the highest risk for all-cause (HR=3.70, 95% CI: 2.19-6.27) and cancer mortality (HR=4.56, 95% CI: 1.99-10.48) as compared to non-asbestos exposed non-smokers. Conclusion: Our results confirm associations of occupational exposure to asbestos with all-cause, benign lung disease, and stomach cancer mortality and underline the impact of joint effects of asbestos and smoking on mortality.

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Asbestos consumption, asbestos exposure and asbestos-related occupational diseases in Germany

Cited by 43 publications

References 17 publications

Malignant Mesothelioma: Global Incidence and Relationship with Asbestos

Malignant Mesothelioma: Global Incidence and Relationship with Asbestos

Simultaneous determination of 3-nitrotyrosine, tyrosine, hydroxyproline and proline in exhaled breath condensate by hydrophilic interaction liquid chromatography/electrospray ionization tandem mass spectrometry

Occupational exposure to asbestos is associated with increased mortality in men recruited for a population-based study in Germany

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