Asbestos Body Content of the Larynx in Asbestos Workers: A Study of Five Cases

Roggli, Victor L.; Greenberg, S. Donald; McLarty, Jerry L.; Hurst, George A.; Spivey, Charles G.; Hieger, Leroy R.

doi:10.1001/archotol.1980.00790330013006

Cited by 27 publications

(8 citation statements)

References 13 publications

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“…Hirsch et al (1979) described ®bres found by TEM in digested specimens of larynx from two asbestos workers, but the same group had previously described how asbestos ®bres could be found in the sputum of workers as long as 30 years after exposure ceased (Bignon et al, 1979). Roggli et al (1980) found asbestos bodies by SEM in asbestos workers; they also found ferruginous bodies in control subjects, which adds a further question mark over the signi®cance of the ®nding. They also add a note of caution about the problem of contamination, which is known to be considerable.…”

Section: Biological Evidencementioning

confidence: 97%

Asbestos exposure and laryngeal cancer

Browne¹

2000

The Annals of Occupational Hygiene

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Objective: To carry out a systematic review of the evidence relating asbestos exposure to the risk of laryngeal cancer. Method: All identi®ed studies of asbestos workers providing data on laryngeal disease were reviewed, together with studies of laryngeal cancers giving epidemiological or experimental evidence of associated exposures. Results: Confounding due to smoking and alcohol intake, and to a lesser extent diet and socioeconomic factors, creates a major diculty over the identi®cation of any asbestos or other occupational eect. Not only are smoking and alcohol independently associated with large increases in relative risk (RR) of laryngeal cancer, but also have a synergistic eect with each other. Few of the studies provide details of either habit. Among 24 prospective studies for which a standardized mortality ratio (SMR) was available, nine had an SMR at or below unity, and among a further 11 without an SMR for comparison, in only one was there a clear excess risk. In 17 retrospective studies, only two showed a signi®cantly increased RR. Evidence from animal experiments, studies of associations with pleural plaques, and autopsy ®ndings also appear negative or inconclusive. Conclusion: The evidence does not indicate that asbestos exposure increases the RR of laryngeal cancer.

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Section: Biological Evidencementioning

confidence: 97%

Asbestos exposure and laryngeal cancer

Browne¹

2000

The Annals of Occupational Hygiene

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“…The small number of events in most studies, the lack of strong evidence of dose-response, and the presence of potential residual confounding in occupational cohort studies are all limitations of the available dataset. In addition, there are no strong data showing accumulation and persistence of asbestos fi bers in the larynx; two studies reported either asbestos bodies [ 71 ] of fi bers [ 44 ] in …”

Section: Asbestosmentioning

confidence: 99%

Laryngeal Cancer

Boffetta¹

2014

Occupational Cancers

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“…Insbesondere durch Veraschung und anschliefende elektronenmikroskopische Untersuchung konnte nach entsprechender Asbestexposition in 5 von 7 Fallen em soicher Fasernachweis gefuhrt werden (9,18 …”

Section: Nachweis Von Asbestfasern Im Kehlkopfgewebeunclassified

Kehlkopfkarzinom und Asbestose

Münzel¹

1986

Laryngo-Rhino-Otol

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Unter Asbest versteht man eine Reihe mineralischer Fasersilikate mit sehr unterschiedlichen physico-chemischen Eigenschaften, die als Serpentin-Asbeste und Amphibo-Asbeste in der Natur vorkommen. Wegen der besonderen Kennzeichen der Nichtbrennbarkeit und des hohen Schmeizpunktes wird Asbest in einer grofen Zahi von Industrien eingesetzt (4, 10). Infoige der faserartigen Struktur wird die Substanz bei der Verarbeitung und Anwendung leicht inhaliert. Durch Einatmung und Ablagerung einer ausreichenden Menge Asbeststaubes in Lunge und Pleura können Lungenfibrosen, Pleurahyalinosen (Plaques, auch mit Verkalkung) und diffuse maligne Pleuramesotheliome

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Asbestos Body Content of the Larynx in Asbestos Workers: A Study of Five Cases

Cited by 27 publications

References 13 publications

Asbestos exposure and laryngeal cancer

Asbestos exposure and laryngeal cancer

Laryngeal Cancer

Kehlkopfkarzinom und Asbestose

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