Arzneimittelsynthetische Studien IX: Benzthiazolylharnstoffe. Mitbearbeitet von P. Schulz

Synthesis of New Unsymmetrical 4,5-Dihydroxy-2-imidazolidinones. Dynamic NMR Spectroscopic Study of the Prototropic Tautomerism in 1-(2-Benzimidazolyl)-3-phenyl-4,5-dihydroxy-2-imidazolidinone

“…N-Heteroaryl-N'-phenylureas 4a-f were prepared through the reaction of suitable primary heteroarylamines (2-aminothiazole, 2-aminopyrimidine, 2-aminopyrazine, 2-aminopyridine, 3-aminopyridine and 2-aminobenzimidazole) with phenyl isocyanate [18][19][20][21]. In refluxing acetonitrile and in the presence of formic acid as catalyst, treatment of compounds 4a-f with aqueous glyoxal afforded the corresponding trans-1-heteroaryl-3-phenyl-4,5-dihydroxy-2-imidazolidinones 5a-f (Scheme 1).…”

6-Methylbenzo[d]thiazol-2-amine

“…For information on the biological and medical applications of aminobenzothiazoles, see: Dessi & Ben-Asi (1993); Benavides et al (1985); Hutchinson et al (2002); El-Sherbeny (2000); Delmas et al (2002); Lá cová et al (1991). For their pesticidal and antimicrobial activities, see: Kaufmann (1935); Pattan et al (2002). For a related structure see Jai-nhuknan et al (1997).…”

“…Bis-substituted amidino benzothiazoles are potential anti-HIV agents (Delmas et al, 2002). 6-Ethoxy-2-amino benzothiazole is a typical strong local anesthetic (Lácová et al, 1991) and acyl derivatives of 4-chloro-2-aminobenzothiazole possess pesticidal activities (Kaufmann, 1935). 2-Substituted 6-nitro and 6-amino benzothiazoles and fluorobenzothiazoles show antimicrobial activity (Pattan et al, 2002).…”

The metabolism of exogenous adenine and purine analogues by fungi

“…Calc. for C9H9N3OS: N, 20-3; acetyl 20-8% (for 1)]; Kaufman & Shulz (1935) recorded m.p. 2390; (b) 5-acetamido-1,2-dimethylbenzimidazole, m.p.…”