Arylnaphthalene lignan glycosides and other constituents from<i>Phyllanthus reticulatus</i>

Ma, Jian-Xiong; Lan, Ming-Sheng; Qu, Shi‐Jin; Tan, Jacqueline; Luo, Haoming; Tan, Chang‐Heng; Zhu, Da‐Yuan

doi:10.1080/10286020.2012.712040

Cited by 14 publications

(9 citation statements)

References 14 publications

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“…Phyllanthus poilanei ) plants of the Phyllanthus genus collected from parts of Asia (Fig. S1A) (47, 48), was able to enhance IFN-γ production by NK cells. We first demonstrated that, when total PBMCs from healthy donors were cultured with PL-C in the presence of the cytokines IL-12 or IL-15 (stimulators of IFN-γ in NK cells, and each constitutively expressed in vivo (49)), intracellular staining for IFN-γ protein assessed via flow cytometric analysis indicated that NK cell IFN-γ production was significantly increased (Fig.…”

Section: Resultsmentioning

confidence: 99%

The Natural Product Phyllanthusmin C Enhances IFN-γ Production by Human NK Cells through Upregulation of TLR-Mediated NF-κB Signaling

Deng

Chu

Ren

et al. 2014

The Journal of Immunology

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Natural products are a major source for cancer drug development. NK cells are a critical component of innate immunity with the capacity to destroy cancer cells, cancer initiating cells, and clear viral infections. However, few reports describe a natural product that selectively stimulates NK cell IFN-γ production and unravel a mechanism of action. In this study, through screening, we found that a natural product, phyllanthusmin C (PL-C), alone enhanced IFN-γ production by human NK cells. PL-C also synergized with IL-12, even at the low cytokine concentration of 0.1 mg/ml, and stimulated IFN-γ production in both human CD56bright and CD56dim NK cell subsets. Mechanistically, TLR1 and/or TLR6 mediated PL-C’s activation of the NF-κB p65 subunit that in turn bound to the proximal promoter of IFNG and subsequently resulted in increased IFN-γ production in NK cells. However, IL-12/IL-15 receptors and their related STAT signaling pathways were not significantly modulated by PL-C. PL-C induced little or no T cell IFN-γ production or NK cell cytotoxicity. Collectively, we identify a natural product with the capacity to selectively activate human NK cell IFN-γ. Given the role of IFN-γ in immune surveillance, additional studies to understand the role of this natural product in prevention of cancer or infection in select populations are warranted.

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Section: Resultsmentioning

confidence: 99%

The Natural Product Phyllanthusmin C Enhances IFN-γ Production by Human NK Cells through Upregulation of TLR-Mediated NF-κB Signaling

Deng

Chu

Ren

et al. 2014

The Journal of Immunology

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“…Methanol [17] Polyphenols (Lignan) (+)-Lyoniresinol (39) (C22H28O8) Ethyl acetate fraction of 95% Ethanol extract [21] Syringaresinol (40)…”

Section: Polyphenols and Phenolicsmentioning

confidence: 99%

“…Reticulatusides A (3′,4′-methylenedioxy-4, 5-dimethoxy-7-hydroxy-2,7′cycloligna-7,7′-dien-9′, 9-olide 7-O-α-L-arabinofuranosyl (1→6)β-D-glucopyranoside) (43) (C32H34O16) Butanol fraction of 95% EtOH extract [21] Reticulatusides B (3′, 4′-methylenedioxy-4-methoxy-5-α-L-arabinofuranosyloxy-7-β-D-glucopyranosyloxy-2,7′-cycloligna-7,7′-dien-9′, 9-olide) (44) (C31H32O16) Butanol fraction of 95% EtOH extract [21] Phyllanthusmins B (45) (C28H26O11) Ethyl acetate fraction of 95% Ethanol extract [21] (continued on next page)…”

Section: Lignin (Glycoside) Mananthoside I (42) (C32h34o16) 75% Etoh ...mentioning

confidence: 99%

Phytochemical account: Phyllanthus reticulatus Poir.

Saleh‐E‐In¹,

Kar²,

Roy³

et al. 2022

JPP

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Phyllanthus reticulatus Poir has long been used in the traditional medications for the treatment of various human diseases most notably diarrhoea, asthma, diabetes and inflammation. Several chromatographic techniques were used to isolate the main active constituents from different parts of the plants using different solvents. Over the last few decades, 57 compounds have been isolated and identified from the P. reticulatus including 12 terpenoids, 4 steroids, 7 flavonoids, 8 phenolics, 8 lignins, 8 tannins, 5 megastigmane glycosides, 3 diterpenoids, 1 purine derivative, 2 acid deravetives and 1 fatty alcohol. This review provided a comprehensive overview of the phytochemistry of P. reticulatus based on the unified review of literature. The review suggests for further avenues of research on the phytochemistry of P. reticulatus to isolate and decipher the unidentified lead compounds for future pharmaceutical applications.

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“…11, 78 , sterols (stigmasterol, β-Sitosterol-3-O-β-glucoside, βsitosterol, Stigmasta-5,6-dihydro-22-en-3β-ol etc.) 9,10, 76 and main lignans are reticulosides A and reticulosides B 79 . Some lignans and compounds isolated from K. reticulata as pentacosane, octacosane, lup-20(29)-en-3β-24-diol, sorghumol and sorghumol acetate, friedelin, epifriedenol, kokoonol, β-sitosterol, taraxerone, teraxeryl acetate, 21α-Hydroxyfriedelin-3-one, betulin, friedelan-3β-ol, betulinic acid, p-comeric acid, ellagic acid, pyrogallic acid, pirorisinol 9,10,70,75,78,80, 81 .…”

Section: Phytochemistrymentioning

confidence: 99%

Kirganelia Reticulata (Poir) Baill.-a Review on Its Botany, Ethnobotany, Phytochemistry and Pharmacology

Soni

Dixit

Chandra

et al. 2013

J. Drug Delivery Ther.

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and is supposed to also occur in tropical parts of Africa 22-27 . The name "Phyllathus means "leaf and flower" because the flower, as well as the fruit, seems to become one with the leaf. The genus (Euphorbiaceae) consists of about 6500 species in 300 genera, of which 200 are ABSTRACT Kirganelia reticulata (Poir.) Baill. is known for its importance in various traditional medicine around the world and are proved pharmacologically as an antiviral against Hepatitis B, hepatoprotective, antidiabetic and antioxidant. In Ayurvedic system of Indian medicine recognized its activity against jaundice, diuretic, fever, liver disorder, in bleeding gums, small pox, syphilis, etc. The review summarizes the up-to-date and comprehensive information concerning the botany, traditional use, phytochemistry and pharmacology of important drug. Kirganelia reticulata and discusses the possible future scope for future research. In present review covers a literature survey across from 1826 to 2012. The some information collected from published literature on species of Kirganelia reticulata (Poir.) Baill. (=Phyllanthus reticulatus Poir.) and traditional ayurvedic texts. Phytochemical studies have shown the presence of many valuable compounds such as lignans, flavonoids, steroids, coumerins, triterpenes, phenols, flavonones, alkaloids are common compounds in test species. The extract and the compounds isolated from Kirganelia reticulata show a wide spectrum of Biological activities including antidiabetic, antibacterial, antioxidant, hepatoprotective, antiplasmodial, anticiceptive, analgesic and anti-inflammatory properties. Conclusion: The present review summarizes information concerning the morphology, ecology, ethanopharmacologically, phytochemistry, and traditional diseases and applications of K. reticulata. This review target at gathering the research work undertaken till date on this plant in order to provide sufficient baseline information for future works and commercial exploitation.

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Arylnaphthalene lignan glycosides and other constituents fromPhyllanthus reticulatus

Abstract: Two new arylnaphthalene lignan glycosides, named reticulatusides A (1) and B (2), together with eight known compounds were isolated from the 95% EtOH extract of the whole plant of Phyllanthus reticulatus. The structures of the new compounds were elucidated by spectroscopic methods.

Cited by 14 publications

References 14 publications

The Natural Product Phyllanthusmin C Enhances IFN-γ Production by Human NK Cells through Upregulation of TLR-Mediated NF-κB Signaling

The Natural Product Phyllanthusmin C Enhances IFN-γ Production by Human NK Cells through Upregulation of TLR-Mediated NF-κB Signaling

Phytochemical account: Phyllanthus reticulatus Poir.

Kirganelia Reticulata (Poir) Baill.-a Review on Its Botany, Ethnobotany, Phytochemistry and Pharmacology

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