Arylmethylene-3H-furan(pyrrol)-2-ones in reactions of [3+2]-cycloaddition with activated hydrazones

Reaction of arylmethylidene derivatives of 3H-furan-2-ones with azomethine ylide

“…12,13 Previously, these little studied compounds have been introduced in cycloaddition reaction with azomethine imines, generated in situ from hydrazones. 14 Based on these substrates the assembly of dispirocyclic systems containing the oxoindole moiety is possible in one step if suitable 1,3-dipoles are employed. Convenient dipoles for constructing pyrrolidine-(pyrrolizidine)oxindole compounds are non-stabilized azomethine ylides generated from isatins.…”