27 year old female with history of atherosclerotic cardiovascular disease and remote myocardial infarction, asthma and provoked deep vein thrombosis (completed anticoagulation) presented with complaints of worsening chest pain and dyspnea for two days. She denied fever, chills, productive cough or sick contacts. She admitted to 70-pound unintentional weight loss over 7 months, decreased appetite, night sweats, diarrhea, and palpitations.Vital signs showed heart rate 95, blood pressure 113/74 mmHg, respiratory rate 14, SpO2 95% on room air. A comprehensive metabolic panel and complete blood count were normal. EKG showed normal sinus rhythm with left ventricular hypertrophy and no ST changes. Urine drug screen was positive for cannabinoid only. Cardiac markers were negative. TSH was 0.01 mclU/mL (0.31-5.00 mclU/mL).Hospital Day 1: Chest x-ray showed a small density projecting over the right upper lung at the intersection of anterior 3 rd and posterior 6 th ribs. Follow up with CT pulmonary angiogram showed indeterminate homogenous solid mass within the anterior superior mediastinum along the aortic arch measuring approximately 5.5cm x 5.3cm x 2.4cm in craniocaudal, transverse and AP dimensions. Mass was not continuous with the thyroid and did not demonstrate cystic or calcified components [ Figures 1 and 2]. Thyromegaly without focal lesion was noted on CT imaging. Heart was normal in size without pericardial effusion and a collapsible Inferior vena cava [ Figure 3]. US thyroid revealed bilateral Thyromegaly with hypervascularity and no discrete nodules.
Hospital Day 2:Due to suspicion for possible lymphoma or thymoma, Interventional radiology and Oncology were consulted to obtain biopsy of anterior mediastinal mass for further evaluation [ Figure 4].Shortly after returning from CT guided-needle biopsy of mediastinal mass, the patient developed nausea, profuse vomiting and became unresponsive. Upon arrival of Rapid Response Team, vital signs were heart rate 150, blood pressure 65/50 mmHg, RR 20, SpO2 95% on 6 L Oxygen. EKG showed sinus tachycardia without ST changes. Patient was given 1 L normal saline bolus and packed red blood cells were emergently prepared given concern for pulmonary artery injury as complication of biopsy. Bedside Ultrasound revealed pericardial effusion, non-collapsible inferior vena cava, and ventricular interdependence demonstrating tamponade physiology . Patient was intubated for airway protection and cardiothoracic surgery was emergently consulted for pericardiocentesis and evacuation of suspected mediastinal hematoma.Chest x-ray confirmed significant mediastinal widening suspicious for mediastinal hematoma [ Figure 8].Review of laboratory studies once patient was transferred to Intensive Care Unit showed TSH 0.01 mclU/mL (0.31-5.00 mclU/mL) with reflex Free T4 > 4.2 ng/dL (0.7-1.7 ng/dL) and T3 > 651 (71-170ng/ dL).Acetylcholine Receptor Binding Antibody was negative. BurchWartofsky score > 45, classifying patient as having Thyroid Storm.Emergent exploratory median sternotomy was perform...