Artificial transmembrane ion transporters as potential therapeutics

Antibacterial Theranostic Agents with Negligible Living Cell Invasiveness: AIE-Active Cationic Amphiphiles Regulated by Alkyl Chain Engineering

“…The extra transesterification occurring for PyC12-PIOC12 is probably attributed to the low reactivity of iodododecane and the alkaline environment provided by the pyridine moiety. Detailed synthesis procedures and characterization data of 1 H NMR, 13 C NMR, and high-resolution mass spectra (HRMS) are provided in the Supporting Information (SI). In addition, the structure of PyMe-PIO and PyBu-PIO is further confirmed by X-ray crystallography analysis for the single crystals cultured in a single solvent of dimethyl sulfoxide (DMSO) and methanol, respectively.…”

“…Instruments. 1 H and 13 C NMR spectra were measured on a Bruker AVANCE III HD 400/500 spectrometer in deuterated methanol or acetone using tetramethylsilane (TMS; δ = 0) as an internal reference at room temperature. HRMS were recorded on a GCT Premier CAB048 mass spectrometer operating in MALDT-TOF mode.…”

“…In addition, bacterial infections for some susceptible populations like diabetics are still problematical, which leads to high rates of disability and mortality . In response, it is an urgent need to develop various advanced approaches to fight against pathogenic bacteria. − Theranostic platforms, integrating both functions of diagnosis and therapy in a single formulation to synchronously achieve target detection, distribution monitoring, therapeutic intervention, and efficacy evaluation, have attracted tremendous attention. , Developing theranostic platforms toward pathogenic bacteria is highly desired to provide more opportunities for precision medicine to meet the practical needs of preventing drug abuse, lowering drug-induced risk, streamlining medication processes, saving healthcare resources, and so forth. − Although tremendous progress has been made in antibacterial theranostic platforms, there still exists plenty of room for improvement in biosafety, accuracy, and efficiency.…”

A Simulation Model for the Non-Electrogenic Uniport Carrier-Assisted Transport of Ions across Lipid Membranes

“…The latter has lately attracted considerable attention, as transmembrane anion transport is crucial to several biological processes [ 9 , 10 , 11 , 12 , 13 , 14 , 15 ]. Failure in maintaining chloride homeostasis in cells is related to various diseases [ 16 ] such as cystic fibrosis, in which a malfunctioning of the cystic fibrosis transmembrane conductance regulator (CFTR) gene causes defective chloride transport [ 17 ]. The development of artificial chloride transmembrane transporters, as substitutes for such defective anion channels, has been tackled during the last two decades [ 18 ].…”

An H2S-Regulated Artificial Nanochannel Fabricated by a Supramolecular Coordination Strategy

“…In response to endogenous stimuli, ion channels within membranes exhibit special transportation properties and therefore affect cell behaviors. − With inspiration from the abundant natural ion channels in biological systems, artificial intelligent nanochannels have attracted tremendous research attention in recent years. − Extensive research efforts have been announced toward the exploitation of novel stimuli to regulate the valves of channels. − To this end, the interfaces or internal walls of channels are decorated using different functional molecules to realize a specific response to environmental stimulation including pH, , temperature, , light, , and specific ions. , For example, Zhou and co-workers coated the anodized aluminum (AAO) with mesoporous carbon-silica (MCS) through an interfacial super-assembly strategy to construct a two-component MCS/AAO composite membrane, which exhibited enhanced permselectivity and could mediate the temperature and pH dual-sensitive ionic transport . Despite the significant progress in external-stimuli-responsive nanochannels, examples of gas-responsive nanochannels are still rare.…”