Artificial skin reduces nutritional requirements in a severely burned child

King, P. F.

doi:10.1016/s0305-4179(99)00186-2

Cited by 25 publications

(7 citation statements)

References 4 publications

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“…even been shown to decrease nutritional requirements. 17,18 More recently, Integra has been combined with cultured autologous keratinocytes and cultured skin substitutes to facilitate early burn wound excision and grafting with minimal donor site morbidity. [19][20][21][22] In addition to its applicability to burn wounds, Integra has also been used in postburn and general reconstruction to reduce scar contracture and donor site morbidity as well as increase function and cosmesis.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Artificial Dermis Neovascularization in an Avascular Wound

Baynosa

Browder

Jones

et al. 2009

J reconstr Microsurg

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Soft tissue coverage for avascular wounds is necessary in reconstructive surgery. Several authors have demonstrated successful treatment of problem wounds using artificial dermis. This study evaluates in an animal model the potential for neovascularization of artificial dermis in devascularized and avascular wound beds. Forty rats were assigned to four groups: (1) control, full-thickness skin graft was replaced on the vascular wound bed; (2) Integra, Integra placed over the full-thickness wound; (3) fascia, the spinotrapezius fascia exposed and Integra placed over the wound; and (4) fascia/Parafilm, a Parafilm layer placed under the raised fascia with Integra over the fascia. Laser Doppler readings were taken at baseline over the intact skin and then over the created wound beds. Biopsies of the full-thickness skin graft and the neodermis were obtained on postoperative day 14 and histologically evaluated for neovascularization. The laser Doppler readings confirmed the nature of the surgically created, poorly vascularized and avascular wound beds. Subsequent biopsies of the artificial dermis in these wound beds, however, demonstrated active neovascularization. This study demonstrates that Integra artificial dermis can serve as an effective dermal substitute in avascular wounds. Lateral ingrowth of capillaries into the dermal substitute may explain the successful integration of this artificial dermis.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Artificial Dermis Neovascularization in an Avascular Wound

Baynosa

Browder

Jones

et al. 2009

J reconstr Microsurg

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“…These have greatly enhanced our ability to care for patients with burn injuries. 8,[17][18][19][20][21][22][23] The products range from temporary epidermal replacements to permanent dermal replacement systems. We have used Integra, a permanent dermal re- Plastic and Reconstructive Surgery • April 2008 placement, for the past 10 years.…”

Section: Discussionmentioning

confidence: 99%

Integra in Lower Extremity Reconstruction after Burn Injury

Lee

Porch

Spenler

et al. 2008

Plastic and Reconstructive Surgery

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The use of a bioengineered, cell-free dermal matrix expands reconstructive options and allows salvage of extremities that might otherwise have been amputated or required prolonged, staged procedures. The authors' experience shows that Integra provides a sound alternative option for providing durable coverage of vital lower extremity structures. It should be considered as part of the lower extremity wound coverage algorithm.

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“…Current clinical indications for use of Integra include cover of soft tissue defects from deep burns, acute trauma, soft tissue tumor resection, and chronic ulcers 1–5,7–10 . Soft tissue reconstruction of the tip of the nose is a true challenge in the young female demanding patient.…”

Section: Discussionmentioning

confidence: 99%

“…Bioengineered tissues are largely used in current clinical practice for tissue loss reconstruction in difficult cases where autologous grafts are unavailable or unsuitable. Artificial skin substitutes are generally used for the acute treatment of huge skin loss in patients in critical general conditions or for functional indications in secondary surgery 1–5 . The authors present the daring use of a bioengineered skin substitute for exclusive aesthetic purposes in the reconstruction of the tip of the nose.…”

mentioning

confidence: 99%