Artificial cornea: surface modification of silicone rubber membrane by graft polymerization of pHEMA via glow discharge

Lee, Shyh-Dar; Hsiue, Ging‐Ho; Kao, Chen‐Yu; Chang, Patricia Chuen-Tsuei

doi:10.1016/0142-9612(96)88709-6

Cited by 74 publications

(36 citation statements)

References 16 publications

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“…15 For the mixture plasma an interaction between NH 2 and CO 2 H groups was considered, which would lead to the formation of NH 3 ϩ /CO 2 Ϫ microareas that would improve biocompatibility.…”

Section: Endothelialization Of Samplesmentioning

confidence: 99%

“…This technique provides a unique and powerful method for changing surface properties by depositing a plasma layer while keeping the bulk structure of the treated material unchanged. Silicone elastomers 13 have already been used in such biomedical applications as catheters and contact lenses and more generally in the cardiopulmonary bypass, 14 in the development of an artificial cornea, 15 and in voice protheses. 16 They have been used in plasma treatment, [17][18][19] mainly in the field of membrane techniques.…”

Section: Introductionmentioning

confidence: 99%

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Improvement of silicone endothelialization by treatment with allylamine and/or acrylic acid low‐pressure plasma

Monge

Mas

Hamzaoui

et al. 2003

J of Applied Polymer Sci

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Plasma polymerization of allylamine, acrylic acid, and an allylamine/acrylic acid mixture on Silastic silicone rubber led to a strong increase in the silicone rubber's hydrophilicity and surface energy. Analysis of the deposited layer by X-ray photoelectron spectroscopy with 20°and 70°takeoff angles showed segregation of the atoms according to the depth and the incorporation of amino groups, oxygenated groups, and both. The endothelialization of untreated and treated samples was evaluated by the seeding and growth of aorta epithelial cells from pigs in cellular adherence (%), doubling time (in hours), and confluent density (10 4 cells/cm 2 ). The best results were obtained with the allylamine/acrylic acid mixture treatment, which brought a biocompatibility to Silastic similar to classic tissue culture on polystyrene plates. The interpretation was based on the presence of NH 3 ϩ /CO 2Ϫ microareas in the deposited layer.

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Section: Endothelialization Of Samplesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Improvement of silicone endothelialization by treatment with allylamine and/or acrylic acid low‐pressure plasma

Monge

Mas

Hamzaoui

et al. 2003

J of Applied Polymer Sci

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“…A method has been developed to produce various surfaces of silicone rubber membrane (SR) by grafting various amounts of poly(2-hydroxy ethyl methacrylate) (PHEMA) onto SR by plasma-induced grafting polymerization (PIP) [235]. hydrogel, whereas a large of adherent CEC is found on SRs grafted with 55 mg cm À2 PHEMA.…”

Section: Corneamentioning

confidence: 99%

“…The CEC is capable of covering the implant completely in 3 weeks, but downgrowth of CEC occurs. Lee et al, thus, believe that heterbifunctional membranes should be developed in the future to prevent it from happening when the membrane is implanted into a rabbit cornea [235].…”

Section: Corneamentioning

confidence: 99%

“…Lee and coworkers study the surface modification of silicone rubber membrane for artificial cornea applications by grafting polymerization utilizing argon plasma glow discharge [234][235][236][237]. A method has been developed to produce various surfaces of silicone rubber membrane (SR) by grafting various amounts of poly(2-hydroxy ethyl methacrylate) (PHEMA) onto SR by plasma-induced grafting polymerization (PIP) [235].…”

Section: Corneamentioning

confidence: 99%

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Plasma-surface modification of biomaterials

Chu

Chen

Wang

et al. 2002

Materials Science and Engineering: R: Reports

1,409

652

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Plasma-surface modification (PSM) is an effective and economical surface treatment technique for many materials and of growing interests in biomedical engineering. This article reviews the various common plasma techniques and experimental methods as applied to biomedical materials research, such as plasma sputtering and etching, plasma implantation, plasma deposition, plasma polymerization, laser plasma deposition, plasma spraying, and so on. The unique advantage of plasma modification is that the surface properties and biocompatibility can be enhanced selectively while the bulk attributes of the materials remain unchanged. Existing materials can, thus, be used and needs for new classes of materials may be obviated thereby shortening the time to develop novel and better biomedical devices. Recent work has spurred a number of very interesting applications in the biomedical field. This review article concentrates upon the current status of these techniques, new applications, and achievements pertaining to biomedical materials research. Examples described include hard tissue replacements, blood contacting prostheses, ophthalmic devices, and other products. #

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Bioengineered Human Corneal Endothelium for Transplantation

Lai¹

2006

Arch Ophthalmol

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Artificial cornea: surface modification of silicone rubber membrane by graft polymerization of pHEMA via glow discharge

Cited by 74 publications

References 16 publications

Improvement of silicone endothelialization by treatment with allylamine and/or acrylic acid low‐pressure plasma

Improvement of silicone endothelialization by treatment with allylamine and/or acrylic acid low‐pressure plasma

Plasma-surface modification of biomaterials

Bioengineered Human Corneal Endothelium for Transplantation

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