Artifical skin. II. Pluronic F‐127 silver nitrate or silver lactate gel in the treatment of thermal burns

Abstract

Pluronic F‐127 was found to be an effective base for the bactriocidal agent silver nitrate or silver lactate following 18–22% surface area full thickness thermal burns. Some protection was afforded by Pluronic F‐127 alone, attesting to its biological activity as an artificial skin. The bacteriocidal agents, however, further enhanced the effectiveness of the dressing as an artificial skin. No inhibition of skin growth and repair was noted and the dressing was equally effective against Psuedomonas aeruginosa and Proteus mirabilis. Indication that natural defense mechanisms in addition to surface infection needs attention was also noted. Conclusion was reached that Pluronic F‐127 is an ideal base for bacteriocidal agents in the treatment of full thickness thermal wounds. In addition, the Pluronic F‐127 dressing with silver nitrate or silver lactate showed promise as an effective biological artificial skin against electrolyte imbalance, heat loss, and bacterial invasion.

A Review of Poloxamer 407 Pharmaceutical and Pharmacological Characteristics

“…Poloxamer 407 gel absorbs sweat gland secretion (70). Local tolerance was described as very satisfactory (15) even in the treatment of thermal burns (99). In contrast, little added values were found to reduce the bacterial colonisation of human skin despite a limitation of biofilm formation (100).…”

Milder Changes in Chemistry Make a Significant Difference in Phase Transition Temperatures for Triblock Copolymers on PEO106‐PPO70‐PEO106 Block Copolymer Chains

“…[1][2][3] The thermally induced phase transition properties and the interactions between hydrophilic and hydrophobic groups in F127 have been used in tissue engineering, [4] and acted as a co-solvent for dispersing and stabilizing lipids in formulating dispersions for biotechnology applications and realizing their potential as drug carriers. [5] Pluronic copolymers have also been used to minimize the protein/peptide capillary wall interaction in peptide mapping and to separate protein/peptide efficiently.…”

“…[5] Pluronic copolymers have also been used to minimize the protein/peptide capillary wall interaction in peptide mapping and to separate protein/peptide efficiently. [6] There are a number of well known thermosensitive polymers available, such as poly(N-isopropylacrylamide) (PNIPA), PNIPA blends [7] or its copolymers [8][9][10][11] and synthetic block copolymers (Pluronics or Poloxamers) of ethylene oxide/propylene oxide (PEO-PPO-PEO), [2,12,13] blocks of poly(ethylene oxide), poly(L-lactic acid), [14] triblock copolymers of polyethylene glycol-poly(lactic/glycolic acid) (PEG-PLGA-PEG), [15] poly(ethylene glycol), polycaprolactone triblock and multiblock copolymers. [16] Some of these have been shown to exhibit temperature-induced reversible phase transition behavior in aqueous solution, and can be applied in drug delivery studies or injectable gels.…”

Phase Transformations in Self‐Assembly Systems for Drug Delivery Applications

“…Specifically, Pluronic F127 has been found attractive as carrier for bacteriocidal silver nitrate and silver lactate. [48] Using these formulations, the mortality rate after full thickness thermal burns in rats could be reduced by up to 65% compared to the control group by use of Pluronic F127 formulations containing bacteriocidal components. As these formulations are efficient against several key bacterial strains, and no inhibition of skin growth and repair is noted, they have been used as artificial skin against electrolyte imbalances, heat loss, and bacterial invasion.…”