Phase Transformations in Self‐Assembly Systems for Drug Delivery Applications

Malmsten, Martin

doi:10.1080/01932690600991755

Cited by 51 publications

(31 citation statements)

References 45 publications

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“…This process is the basis of the wide application of surfactants in isolation and purification of membrane proteins [4][5][6], in DNA extraction [7,8] and as drug delivery vehicles [9][10][11][12][13][14], among others.…”

Section: Introductionmentioning

confidence: 99%

Mixed micelle formation between amino acid-based surfactants and phospholipids

Faustino

Calado

García‐Río

2011

Journal of Colloid and Interface Science

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Section: Introductionmentioning

confidence: 99%

Mixed micelle formation between amino acid-based surfactants and phospholipids

Faustino

Calado

García‐Río

2011

Journal of Colloid and Interface Science

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“…We found that an increase in the concentration of water in this region yielded more viscous gels (highviscosity system), as a result of solvation of the polar head of the surfactant, forming more organized structures such as hexagonal mesophases. [43][44][45] Emulsion systems were obtained in the regions with a low surfactant concentration (0%-30%) and a high aqueous phase concentration (80%-100%). Phase separation took place when the surfactant concentration increased in the emulsion regions (.70%) and at aqueous concentrations .75%, indicating that dilution with water resulted in poor stability.…”

mentioning

confidence: 99%

Design, characterization, and biological evaluation of curcumin-loaded surfactant-based systems for topical drug delivery

Fonseca-Santos

Santos

Rodero

et al. 2016

IJN

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From previous studies, it has been found that curcumin exhibits an anti-inflammatory activity and is being used for the treatment of skin disorders; however, it is hydrophobic and has weak penetrating ability, resulting in poor drug transport through the stratum corneum. The aim of this study was to develop liquid crystalline systems for topical administration of curcumin for the treatment of inflammation. These liquid crystalline systems were developed from oleic acid, polyoxypropylene (5) polyoxyethylene (20) cetyl alcohol, and water as the surfactant, oil phase, and aqueous phase, respectively. These systems were characterized, and polarized light microscopy showed anisotropy with lamellar mesophases (Formulation 1) and hexagonal mesophases (Formulations 2 and 3), which were confirmed by the peak ratio measured using small-angle X-ray scattering. In addition, rheological tests revealed that the formulations exhibited gel-like behavior (G′>G″), as evidenced by the increased G′ values that indicate structured systems. Texture profile analysis showed that hexagonal mesophases have high values of hardness, adhesiveness, and compressibility, which indicate structured systems. In vitro studies on bioadhesion revealed that the hexagonal mesophases increased the bioadhesiveness of the systems to the skin of the pig ear. An in vivo inflammation experiment showed that the curcumin-loaded hexagonal mesophase exhibited an anti-inflammatory activity as compared to the positive control (dexamethasone). The results suggest that this system has a potential to be used as a bioadhesive vehicle for the topical administration of curcumin. Therefore, it is possible to conclude that these systems can be used for the optimization of drug delivery systems to the skin.

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“…For instance, they are used in protein crystallization 22 , separation of biomolecules 23 , as food stabilizers e.g., in desserts 24 , and in the delivery of active molecules such as nutrients, flavors and perfumes [25][26][27][28][29][30][31] . Self-assembled lipid nanostructures not only have the ability to release bioactive molecules in a controlled and targeted fashion [32][33][34][35][36][37][38] but they are also able to protect the functional molecules from chemical and enzymatic degradation 39,40 . Although planar fluid bilayer is the most common nanostructure formed by amphiphilic lipid molecules in presence of water, other structures such as hexagonal and cubic are also commonly observed 20,41,42 .…”

Section: Introductionmentioning

confidence: 99%

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Patil-Sen

Sadeghpour

Rappolt

et al. 2016

JoVE

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We present a facile method to prepare nanostructured lipid particles stabilized by carbon nanotubes (CNTs). Single-walled (pristine) and multiwalled (functionalized) CNTs are used as stabilizers to produce Pickering type oil-in-water (O/W) emulsions. Lipids namely, Dimodan U and Phytantriol are used as emulsifiers, which in excess water self-assemble into the bicontinuous cubic Pn3m phase. This highly viscous phase is fragmented into smaller particles using a probe ultrasonicator in presence of conventional surfactant stabilizers or CNTs as done here. Initially, the CNTs (powder form) are dispersed in water followed by further ultrasonication with the molten lipid to form the final emulsion. During this process the CNTs get coated with lipid molecules, which in turn are presumed to surround the lipid droplets to form a particulate emulsion that is stable for months. The average size of CNT-stabilized nanostructured lipid particles is in the submicron range, which compares well with the particles stabilized using conventional surfactants. Small angle X-ray scattering data confirms the retention of the original Pn3m cubic phase in the CNT-stabilized lipid dispersions as compared to the pure lipid phase (bulk state). Blue shift and lowering of the intensities in characteristic G and G' bands of CNTs observed in Raman spectroscopy characterize the interaction between CNT surface and lipid molecules. These results suggest that the interactions between the CNTs and lipids are responsible for their mutual stabilization in aqueous solutions. As the concentrations of CNTs employed for stabilization are very low and lipid molecules are able to functionalize the CNTs, the toxicity of CNTs is expected to be insignificant while their biocompatibility is greatly enhanced. Hence the present approach finds a great potential in various biomedical applications, for instance, for developing hybrid nanocarrier systems for the delivery of multiple functional molecules as in combination therapy or polytherapy. Video LinkThe video component of this article can be found at

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Phase Transformations in Self‐Assembly Systems for Drug Delivery Applications

Cited by 51 publications

References 45 publications

Mixed micelle formation between amino acid-based surfactants and phospholipids

Mixed micelle formation between amino acid-based surfactants and phospholipids

Design, characterization, and biological evaluation of curcumin-loaded surfactant-based systems for topical drug delivery

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

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