Articular Cartilage Engineering with Hyalograft?? C

Marcacci, Maurilio; Berruto, Massimo; Brocchetta, Domenico; Delcogliano, A.; Ghinelli, Diego; Gobbi, Alberto; Kon, Elizaveta; Pederzini, Luigi Adriano; Rosa, Donato; Sacchetti, Gian Luigi; Stefani, G; Zanasi, S.

doi:10.1097/01.blo.0000165737.87628.5b

Cited by 418 publications

(304 citation statements)

References 33 publications

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“…Despite the small number of patients in our study, the data are consistent with other studies utilizing hyaluronan [21,27] or collagen matrices in longer-term followups [2]. However, BioCart TM II is a human-derived product that is self-adhesive due to its high-interval fibrinogen content, and implantation can be achieved with a minimally invasive surgical approach because there is no need to suture the graft to the defect site; all implants were suitably fixed to the adjacent cartilage with fibrin glue.…”

Section: Discussionsupporting

confidence: 91%

“…Successful applications of biodegradable matrices for chondrocyte transplantation utilizing a nonwoven mesh of hyaluronan has proven that hyaluronan can serve as a scaffold for cultured chondrocytes and allows implantation by gluing the cell-seeded constructs with fibrin. Clinical studies with midterm results confirm improvement of the clinical performance comparable with ACT, but with less surgical trauma with respect to the incision and time of surgery by avoiding suturing of the implant [9,20,21,27]. Additionally, the fibrin-hyaluronan matrix with its unique structure presents an important advantage with a high seeding efficacy and maintenance of the chondrocytic phenotype.…”

Section: Discussionmentioning

confidence: 64%

“…This approach allows a more predictable transport of the cells into the defect without the need for suturing. Most of the biomaterials used in these techniques are natural biopolymers such as collagen [7,8,24] or hyaluronan [10,21,27] derived from animals or synthetic materials like polylactides [6].…”

Section: Introductionmentioning

confidence: 99%

“…This biocompatible, 3-D scaffold has been tested preclinically in conjunction with autologous cells with high chondrogenic potential obtained with the use of a proprietary FGF variant but this is the first report of the use in a clinical setting. Other studies on matrix assisted chondrocyte transplantation suggest an improvement of function and pain [21,27,28]. Apart from biopsies, high-resolution MRI and well-defined MRI variables are a reliable, reproducible and accurate tool for assessing cartilage repair tissue [22].…”

Section: Introductionmentioning

confidence: 99%

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Results of Chondrocyte Implantation with a Fibrin-Hyaluronan Matrix: A Preliminary Study

Nehrer

Chiari

Domayer

et al. 2008

Clin Orthop Relat Res

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Fibrin, a homologous polymer, is the natural scaffold of wound healing and therefore a candidate as a carrier for cell transplantation. We explored a novel matrix-based implant cartilage repair composed of both fibrin and hyaluronan in a defined ratio that takes advantage of the biological and mechanical properties of these two elements. The matrix was seeded with autologous chondrocytes expanded in the presence of a proprietary growth factor variant designed to preserve their chondrogenic potential. We prospectively followed eight patients with symptomatic-chronic cartilage defects treated with this carrier. Patients had arthroscopy to harvest autologous chondrocytes then grown in autologous serum. Chondrocytes were cultured in the presence of the FGF variant and then seeded on the fibrin-hyaluronan matrix. About 4 weeks following biopsy, the patients underwent implantation of the constructs by miniarthrotomy. Three of the eight patients had transient effusion. Clinical performance was measured by Lysholm and IKDC scores, MRI, and the need for secondary surgery. The clinical outcome of a 1-year followup demonstrated increase of clinical scores.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 64%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Results of Chondrocyte Implantation with a Fibrin-Hyaluronan Matrix: A Preliminary Study

Nehrer

Chiari

Domayer

et al. 2008

Clin Orthop Relat Res

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“…Direct comparison of the data was again difficult because the studies included patients who had biopsies at different time points after surgery. The tissue appeared to mature for at least 18 months after surgery with more hyaline-like tissue from biopsies the further out from surgery [24]. Autologous matrix-(or collagen-) induced chondrogenesis have shown good short-term (2-year) clinical outcomes.…”

Section: Studies On Matrices For Matrix-assisted Cartilage Repairmentioning

confidence: 99%

What Is the Effect of Matrices on Cartilage Repair? A Systematic Review

Wylie

Hartley

Kapron

et al. 2015

Clinical Orthopaedics &Amp; Related Research

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Background Articular cartilage has minimal endogenous ability to undergo repair. Multiple chondral restoration strategies have been attempted with varied results. Questions/purposes The purpose of our review was to determine: (1) Does articular chondrocyte transplantation or matrix-assisted articular chondrocyte transplantation provide better patient-reported outcomes scores, MRI morphologic measurements, or histologic quality of repair tissue compared with microfracture in prospective comparative studies of articular cartilage repair; and (2) which available matrices for matrix-assisted articular chondrocyte transplantation show the best patient-reported outcomes scores, MRI morphologic measurements, or histologic quality of repair tissue? Methods We conducted a systematic review of PubMed, CINAHL, and MEDLINE from March 2004 to February 2014 using keywords determined to be important for articular cartilage repair, including ''cartilage'', ''chondral'', ''cell source'', ''chondrocyte'', ''matrix'', ''augment'', ''articular'', ''joint'', ''repair'', ''treatment'', ''regeneration'', and ''restoration'' to find articles related to cell-based articular cartilage repair of the knee. The articles were reviewed by two authors (JDW, MKH), our study exclusion criteria were applied, and articles were determined to be relevant (or not) to the research questions. The Methodological Index for Nonrandomized Studies (MIN-ORS) scale was used to judge the quality of nonrandomized manuscripts used in this review and the Jadad score was used to judge the quality of randomized trials. Seventeen articles were reviewed for the first research question and 83 articles were reviewed in the second research question from 301 articles identified in the original systematic search. The average MINORS score was 9.9 (62%) for noncomparative studies and 16

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