Arthroscopic autologous chondrocyte implantation in the ankle joint

Giannini, Sandro; Buda, Roberto; Ruffilli, Alberto; Cavallo, Marco; Pagliazzi, Gherardo; Bulzamini, Maria Chiara; Desando, Giovanna; Luciani, Deianira; Vannini, Francesca

doi:10.1007/s00167-013-2640-7

Cited by 77 publications

(77 citation statements)

References 36 publications

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“…The goal of the finest surgical procedure should be the regeneration, restoring worn tissue with high biomechanical quality hyaline cartilage. To date, only osteochondral grafts and regenerative techniques, like autologous chondrocyte implantation (ACI) and bone marrow-derived cell transplantation (BMDCT), have proven effective at this purpose [4][5][6][7][8][9][10][11][12][13]. Nevertheless, osteochondral autograft is a technically demanding procedure with many drawbacks, and other techniques may be preferable [4].…”

Section: Introductionmentioning

confidence: 99%

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Regenerative treatment in osteochondral lesions of the talus: autologous chondrocyte implantation versus one-step bone marrow derived cells transplantation

Buda

Vannini

Castagnini

et al. 2015

International Orthopaedics (SICOT)

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Section: Introductionmentioning

confidence: 99%

“…After three to four weeks, they are implanted at the site of the lesion. The technique was firstly performed open-field; then, thanks to the use of scaffolds, an arthroscopic approach was developed, making the procedure easier and faster and reducing the morbidity and costs [5,[9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Regenerative treatment in osteochondral lesions of the talus: autologous chondrocyte implantation versus one-step bone marrow derived cells transplantation

Buda

Vannini

Castagnini

et al. 2015

International Orthopaedics (SICOT)

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“…Conversely, MFx is known to be less effective in patients with larger chondral lesions (2-4 cm 2 ) or early osteoarthritis [13]. In the knee and talus, large chondral defects are successfully treated with autologous chondrocyte implantation (ACI) or matrix-associated autologous chondrocyte implantation (MACI) [14][15][16][17][18][19][20][21][22]. ACI has also been effectively used in the hip.…”

Section: Introductionmentioning

confidence: 99%

Five-year results of arthroscopic techniques for the treatment of acetabular chondral lesions in femoroacetabular impingement

Mancini

Fontana²

2014

International Orthopaedics (SICOT)

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Purpose This study assesses and compares the clinical outcomes of the arthroscopic matrix-induced autologous chondrocyte implant (MACI) and autologous matrix-induced chondrogenesis (AMIC) techniques for the treatment of acetabular chondral defects between 2 and 4 cm 2 consequent to femoral acetabular impingement. Methods Fifty-seven consecutive patients were treated with the MACI (n=26) or AMIC (n=31) technique. Patients were assessed pre-operatively and up to five years using the modified Harris Hip Score (mHHS) to compare outcomes. Results In both the MACI and AMIC groups, significant hip score improvements were measured over baseline levels at six months post-op (81.2±8.4 for MACI, 80.3±8.3 for AMIC, both p<0.001). The mHHS continued to improve up to three years post-op and remained stable over time until the final five year follow-up. Statistically significant differences between the groups were not observed. The mean mHHS improvement at the five year follow-up with respect to preoperative level was 37.8±5.9 and 39.1±5.9 in patients who underwent MACI and AMIC, respectively (NS). Subgroup analysis of both MACI and AMIC treatment outcomes for patients with an initial chondral defect larger than 3 cm 2 yielded comparable results at each time point. Conclusions This study suggests that both arthroscopic MACI and AMIC are valid procedures to repair mediumsized chondral defects on the acetabular side of the hip found during treatment of femoroacetabular impingement. Due to its high sustainability and minimal invasiveness, the single-stage AMIC procedure can reduce total treatment time and minimise morbidity while providing the same beneficial effects as the two-stage MACI intervention.

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“…The mean AOFAS score improved from 36.9 preoperatively to 83.9 postoperatively, and 50% patients returned to previous sports. Giannini et al [44] reported, in what we believe to be the largest case series with the longest follow-up, a study involving 46 ankles with a mean follow-up of 87.2 months. The authors reported that the mean AOFAS score was 92 at final follow-up.…”

Section: Matrix-induced Autologous Chondrocyte Implantationmentioning

confidence: 73%

Osteochondral lesions of the talus in the athlete: up to date review

Shimozono

Yasui

Ross

et al. 2017

Curr Rev Musculoskelet Med

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Purpose of review Osteochondral lesions of the talus (OLT) are common injuries in athletes. The purpose of this study is to comprehensively review the clinical results and return to sport capacity in athletes following treatment for OLT. Recent findings Reparative procedures, such as bone marrow stimulation, and replacement procedures, such as autologous osteochondral transplantation, provide good clinical outcomes in short-and mid-term follow-up in the athlete. Recently, biological augmentation and scaffold-based therapies have been shown to improve clinical and radiological outcomes in OLT in both the general population and athletes. Summary Most studies are of a low level of evidence. Studies analyzing the return to sport capability in athletes are further lacking. High-level evidence and well-designed clinical trials are required to establish the most effective treatment protocol.

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Arthroscopic autologous chondrocyte implantation in the ankle joint

Abstract: IV, retrospective case series.

Cited by 77 publications

References 36 publications

Regenerative treatment in osteochondral lesions of the talus: autologous chondrocyte implantation versus one-step bone marrow derived cells transplantation

Regenerative treatment in osteochondral lesions of the talus: autologous chondrocyte implantation versus one-step bone marrow derived cells transplantation

Five-year results of arthroscopic techniques for the treatment of acetabular chondral lesions in femoroacetabular impingement

Osteochondral lesions of the talus in the athlete: up to date review

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