Arthritis in Systemic Lupus Erythematosus: From 2022 International GISEA/OEG Symposium

Ceccarelli, Fulvia; Govoni, Marcello; Piga, Matteo; Cassone, Giulia; Cantatore, Francesco Paolo; Olivieri, G.; Cauli, Alberto; Favalli, Ennio Giulio; Atzeni, Fabiola; Gremese, Elisa; Iannone, Florenzo; Caporali, Roberto; Sebastiani, Marco; Ferraccioli, G; Lapadula, Giovanni; Conti, Fabrizio

doi:10.3390/jcm11206016

Cited by 13 publications

(11 citation statements)

References 65 publications

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“…It is projected that TB screening and treatment will save 66 million lives between 2000 and 2020. The most recent national TB patient cost survey found that more than one in two TB-affected households have costs that exceed 20% of their family income [ 73 ]. The global target of eliminating catastrophic expenditures associated with TB for patients or their households by 2020 was not achieved.…”

Section: Epidemiologymentioning

confidence: 99%

“…The global target of eliminating catastrophic expenditures associated with TB for patients or their households by 2020 was not achieved. By 2022, it will be necessary to spend US$ 13 billion per year on TB prevention, diagnosis, treatment, and care in order to fulfill the global objective set at the UN high-level meeting on TB in 2018 [ 73 ]. Ninety-eight percent of tuberculosis (TB) cases that are recorded take place in low- and middle-income countries (LMICs), where financing is much less than what is required.…”

Section: Epidemiologymentioning

confidence: 99%

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Treatments of Mycobacterium tuberculosis and Toxoplasma gondii with Selenium Nanoparticles

Ifijen

Atoe²,

Ekun

et al. 2023

BioNanoSci.

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Toxoplasma gondii and Mycobacterium tuberculosis are pathogens that are harmful to humans. When these diseases interact in humans, the result is typically fatal to the public health. Several investigations on the relationship between M. tuberculosis and T. gondii infections have found that there is a strong correlation between them with each infection having a reciprocal effect on the other. TB may contribute to the reactivation of innate toxoplasmosis or enhance susceptibility to a new infection, and toxoplasma co-infection may worsen the severity of pulmonary tuberculosis. As a consequence, there is an earnest and urgent necessity to generate novel therapeutics that can subdue these challenges. Selenium nanostructures’ compelling properties have been shown to be a successful treatment for Mycobacterium TB and Toxoplasma gondii. Despite the fact that selenium (Se) offers many health advantages for people, it also has a narrow therapeutic window; therefore, consuming too much of either inorganic or organic compounds based on selenium can be hazardous. Compared to both inorganic and organic Se, Se nanoparticles (SeNPs) are less hazardous. They are biocompatible and excellent in selectively targeting specific cells. As a consequence, this review conducted a summary of the efficacy of biogenic Se NPs in the treatment of tuberculosis (TB) and toxoplasmosis. Mycobacterium tuberculosis , Toxoplasma gondii , and their co-infection were all briefly described.

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Section: Epidemiologymentioning

confidence: 99%

Section: Epidemiologymentioning

confidence: 99%

Treatments of Mycobacterium tuberculosis and Toxoplasma gondii with Selenium Nanoparticles

Ifijen

Atoe²,

Ekun

et al. 2023

BioNanoSci.

View full text Add to dashboard Cite

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“…In OS ADs, the immune response is directed toward single-organ antigens. The most common OS AD is autoimmune thyroid disease (AITD) [ 5 , 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Molecular Mechanisms in Autoimmune Thyroid Disease

Vargas‐Uricoechea

2023

Cells

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The most common cause of acquired thyroid dysfunction is autoimmune thyroid disease, which is an organ-specific autoimmune disease with two presentation phenotypes: hyperthyroidism (Graves-Basedow disease) and hypothyroidism (Hashimoto’s thyroiditis). Hashimoto’s thyroiditis is distinguished by the presence of autoantibodies against thyroid peroxidase and thyroglobulin. Meanwhile, autoantibodies against the TSH receptor have been found in Graves-Basedow disease. Numerous susceptibility genes, as well as epigenetic and environmental factors, contribute to the pathogenesis of both diseases. This review summarizes the most common genetic, epigenetic, and environmental mechanisms involved in autoimmune thyroid disease.

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“…SLE can cause significant disability, multiplying the morbidity and mortality risks of patients [ 5 , 6 , 7 ], with the juvenile-onset form being associated with even greater mortality risk compared to the adult form [ 8 ]. Common clinical manifestations involve fever, joint pain and arthritis, oral ulcerations, alopecia, malar rash, photosensitivity, and Raynaud’s phenomenon [ 9 , 10 , 11 , 12 , 13 ]. Organ-system involvement in SLE can include the musculoskeletal system and the skin, the kidneys, lungs, heart, and many more [ 9 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Anorexia Nervosa in Juvenile Systemic Lupus Erythematosus (SLE): A Causality Dilemma

et al. 2023

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Juvenile-onset systemic lupus erythematosus (jSLE) is an autoimmune disorder with multifaceted clinical findings in different organ systems. Neuropsychiatric manifestations affect more than half of SLE patients, and there is increasing evidence that anorexia nervosa (AN), a feeding and eating disorder (FED) characterized by significantly reduced energy intake, is among them. Herein, a review of the literature on the potential association between jSLE and AN was performed. Reported clinical cases were identified, and putative pathophysiological mechanisms were sought that could potentially explain the observed relationship between these two pathological entities. Four reports of isolated cases and a case series including seven patients were identified. In this limited patient pool, the diagnosis of AN preceded that of SLE in the majority of cases, whereas in all cases both entities were diagnosed within a time span of two years. Many explanations for the observed relationships have been proposed. AN has been associated with the stress of chronic disease diagnosis; on the other hand, the chronic inflammation associated with AN may contribute to the development/appearance of SLE. Adverse childhood experiences, concentrations of leptin, shared autoantibodies, and genetic traits appear to be important factors in this well-established interplay. In essence, it seems important to increase clinician awareness of the concomitant development of AN and SLE and invite further research on the subject.

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Arthritis in Systemic Lupus Erythematosus: From 2022 International GISEA/OEG Symposium

Cited by 13 publications

References 65 publications

Treatments of Mycobacterium tuberculosis and Toxoplasma gondii with Selenium Nanoparticles

Treatments of Mycobacterium tuberculosis and Toxoplasma gondii with Selenium Nanoparticles

Molecular Mechanisms in Autoimmune Thyroid Disease

Anorexia Nervosa in Juvenile Systemic Lupus Erythematosus (SLE): A Causality Dilemma

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