Arthritis Associated with Recurrent Erythema Multiforme Responding to Oral Acyclovir

Molnár, István; Matulis, M

doi:10.1007/s100670200111

Cited by 12 publications

(5 citation statements)

References 7 publications

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“…It has been suggested that recurrent herpesassociated EM may be prevented by continuous treatment with low-dose oral aciclovir (e.g. 400 mg twice daily; [160][161][162][163][164][165][166][167] or valaciclovir (168).…”

Section: Other Diseases Associated With Hsv-1 Infectionmentioning

confidence: 99%

Herpes Simplex Virus Type 1 infection: overview on relevant clinico‐pathological features*

Arduino

Porter

2007

J Oral Pathology Medicine

330

256

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Herpes Simplex Virus Type 1 (HSV-1) is a nuclear replicating enveloped virus, usually acquired through direct contact with infected lesions or body fluids (typically saliva). The prevalence of HSV-1 infection increases progressively from childhood, the seroprevalence being inversely related to socioeconomic background. Primary HSV-1 infections in children are either asymptomatic or following an incubation period of about 1 week gives rise to mucocutaneous vesicular eruptions. Herpetic gingivostomatitis typically affects the tongue, lips, gingival, buccal mucosa and the hard and soft palate. Most primary oro-facial HSV infection is caused by HSV-1, infection by HSV-2 is increasingly common. Recurrent infections, which occur at variable intervals, typically give rise to vesiculo-ulcerative lesions at mucocutaneous junctions particularly the lips (herpes labialis). Recurrent HSV-1 infection within the mouth is uncommon in otherwise healthy patients, although in immunocompromised patients, recurrent infection can be more extensive and/or aggressive. The diagnosis of common herpetic infection can usually be based upon the clinical history and presenting features. Confirmatory laboratory diagnosis is, however, required when patients are, or may be, immunocompromised.

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Section: Other Diseases Associated With Hsv-1 Infectionmentioning

confidence: 99%

Herpes Simplex Virus Type 1 infection: overview on relevant clinico‐pathological features*

Arduino

Porter

2007

J Oral Pathology Medicine

330

256

View full text Add to dashboard Cite

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“…Famciclovir may also be useful as prophylactic anti‐HSV therapy for cutaneous laser resurfacing (Alster and Nanni, 1999) in patients with a strong history of HSV. Recurrent herpes‐associated erythema multiforme may be controlled by continuous treatment with low‐dose oral ACV (Lemak et al , 1986; Morel and Barth, 1986; Molin, 1987; Huff, 1988; Tatnall et al , 1995; Cheriyan and Patterson, 1996; Molnar and Matulis, 2002), also in children (Weston and Morelli, 1997). One RCT of continuous ACV therapy in recurrent erythema multiforme (Tatnall et al , 1995) demonstrated that 400 mg twice daily completely suppresses recurrent attacks and, in some cases, may induce disease remission.…”

Section: Prophylactic Therapy Of Recurrent Oral and Perioral Hsv‐1 Inmentioning

confidence: 99%

Oral and perioral herpes simplex virus type 1 (HSV‐1) infection: review of its management*

Arduino¹,

Porter²

2006

Oral Diseases

130

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Herpes simplex virus type 1 (HSV-1) gives rise to a variety of clinical disorders and is a major cause of morbidity and mortality worldwide. HSV-1 infections are common in oral and perioral area. The aim of the present report was to critically examine the published literature to evaluate the advantages and limitations of therapy of HSV-1 infection in both immunocompetent and immunocompromised patients. Systemic antiviral therapy has been widely accepted as effective for primary herpetic gingivostomatitis. Aciclovir (ACV) 5% cream seems to be the accepted standard topical therapy for herpes labialis, being both effective and well tolerated, although penciclovir 1% cream has been proposed as a potentially useful treatment. Systemic ACV may be effective in reducing the duration of symptoms of recurrent HSV-1 infection, but the optimal timing and dose of the treatment are uncertain. Aciclovir and famciclovir may be of benefit in the acute treatment of severe HSV-1 disease in immunocompromised patients. There is also evidence that prophylactic oral ACV may reduce the frequency and severity of recurrent attack of herpetic infection in immunocompromised patients, but the optimal timing and duration of treatment is uncertain and can vary in different situations.

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“…A similar case was reported wherein the recurrent cutaneous lesions of erythema multiforme and polyarthritis responded to oral acyclovir [13]. The resolution of the cutaneous lesions as well as the arthritis with anti-viral drugs could be due to the common pathogenesis of the two conditions which would require further studies.…”

Section: Discussionmentioning

confidence: 84%

Recurrent erythema multiforme with arthritis – A rare association

Bhat¹,

Zeerak²,

Baba³

et al. 2017

Our Dermatol Online

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Arthritis Associated with Recurrent Erythema Multiforme Responding to Oral Acyclovir

Cited by 12 publications

References 7 publications

Herpes Simplex Virus Type 1 infection: overview on relevant clinico‐pathological features*

Herpes Simplex Virus Type 1 infection: overview on relevant clinico‐pathological features*

Oral and perioral herpes simplex virus type 1 (HSV‐1) infection: review of its management*

Recurrent erythema multiforme with arthritis – A rare association

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