Arthritis associated with inflammatory bowel disease in children

Passo, Murray H.; Fitzgerald, Joseph F.; Brandt, Kenneth D.

doi:10.1007/bf01320313

Cited by 56 publications

(14 citation statements)

References 26 publications

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“…Perhaps this explains why the proportion of our subjects with enthesitis was similar to the background prevalence among otherwise healthy children [13]. The widespread use of these therapies, often in combination, for many children with IBD may also explain the lower rates of arthritis emerging from more recent studies [5,23] in comparison with older studies [2,3]. Of note, several potentially eligible subjects with more active bowel disease declined participation in this study.…”

Section: Discussionmentioning

confidence: 79%

“…As such we were underpowered to assess the relationship between enthesitis with other clinical characteristics, including arthritis, HLA-B27 positivity, and IBD phenotype and disease activity. Previous studies of children and adults with IBD, for example, have showed that arthritis tends to occur more commonly among those with colonic disease [3,21,22]. Future studies should be powered to make these statistical comparisons.…”

Section: Discussionmentioning

confidence: 99%

“…Among the most prevalent extra-intestinal complications of IBD is arthritis, even among children [1]. Arthritis has been reported in as many as 14–25% of pediatric IBD patients [2,3]. More recent studies of extraintestinal manifestations in pediatric IBD patients reported peripheral arthritis in around 4%[4,5].…”

Section: Introductionmentioning

confidence: 99%

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Enthesitis is an extraintestinal manifestation of pediatric inflammatory bowel disease

et al. 2012

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Background Enthesitis is an extra-intestinal manifestation of inflammatory bowel disease (IBD) in adults. However, little has been published about the prevalence or characteristics of enthesitis in pediatric IBD. Methods We conducted a cross-sectional study of children and young adults ages 4–21 years with IBD. Subjects were recruited among those receiving routine care in a gastroenterology clinic. All subjects underwent a clinical examination of the entheses and joints, and completed a study questionnaire. Results We enrolled 43 subjects, who had a median age of 16 years and a median time from IBD diagnosis of 2.7 years. 32 subjects (74%) had Crohn disease, 10 subjects (23%) had indeterminate colitis, and 1 subject (2%) had ulcerative colitis. At least one tender enthesis was present in 21% of subjects and 12% had more than 2 tender entheses. The most commonly affected entheses were located at the inferior patella, the femoral greater trochanter, and the proximal humerus. The presence of enthesitis was associated with a higher intensity of recent musculoskeletal pain (p=0.03). Conclusions Enthesitis is a prevalent extra-intestinal manifestation of pediatric IBD and is associated with increased musculoskeletal pain. Future studies should evaluate the functional and long-term impact of enthesitis on children with IBD.

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Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

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Enthesitis is an extraintestinal manifestation of pediatric inflammatory bowel disease

et al. 2012

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“…As previously mentioned, the arthritis is pauciarticular. Arthritis begins in the lower limb and the most frequently affected joints are knees, ankles, hips, and elbows, while the finger-joints are less commonly attacked [6,14-16].…”

Section: Reviewmentioning

confidence: 99%

Relationship between Ulcerative Colitis and Rheumatoid Arthritis: A Review

Attalla¹,

Singh²,

Khalid³

et al. 2019

Cureus

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Ulcerative colitis (UC) is a colonic disease characterized by chronic inflammation. Rheumatoid arthritis (RA) is a rheumatological chronic inflammatory disease characterized by joint swelling and tenderness. It is also considered an autoimmune disorder. We want to discover if a link exists between UC and RA and if so, how UC affects the progress of arthritis. We used PRISMA guidelines. In this study, we used PubMed, PubMed Central (PMC), and Google Scholar to collect data. Studies conducted more than 50 years ago, non-English articles, and animal studies were excluded. All types of studies were included. We used keywords like "ulcerative colitis", "rheumatoid arthritis", or "colitic arthritis" in the search.We identified the following sets of results: 187,611 PubMed studies, 197,610 PMC studies, and 2,282,000 Google scholar studies. After applying inclusion and exclusion criteria, the number of appropriate studies was narrowed down to 50.Arthritis is the most common complication of ulcerative UC. The radiological changes are similar to those seen in RA. There are common genes and antigens found in both diseases, such as human leukocyte antigen (HLA-B27), interleukin 15, IgA. Certain drugs used for the treatment of both disorders, including omega-3. Many studies revealed that a large number of patients with UC developed RA within a few years.All the findings prove that there is a relation between ulcerative colitis and rheumatoid arthritis. This study is useful for doctors, scientists, and patients.

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“…There are several studies that characterize the MSK EIMs in adult IBD; however, data for p‐IBD are sparse. In 1986, Passo et al (10) were the first to describe the association of arthritis in patients with p‐IBD. In this retrospective study, arthritis was described in 9% of children with UC and in 15.5% of children with CD.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of Musculoskeletal Manifestations in Pediatric Inflammatory Bowel Disease: A Systematic Review

Ali

Schmidt

Piskin

et al. 2022

ACR Open Rheumatology

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Objective Pediatric inflammatory bowel disease (p‐IBD) is a chronic relapsing gastrointestinal disorder of childhood with long‐term morbidity. Several extraintestinal manifestations are described, the most common being joint pain and/or inflammation. However, patient and disease characteristics, treatments, and outcomes of p‐IBD‐associated musculoskeletal disease are not well established. Our study aims to summarize the recent literature on the epidemiology of musculoskeletal manifestations in p‐IBD in the era of biologics. Methods A systematic search of PubMed, Embase, Cochrane Library, Web of Science Core Collection, and Cumulative Index to Nursing and Allied Health Literature databases was performed with relevant keywords. Studies in English published from January 1, 2000, to December 21, 2020, were included. In total, 3893 articles were identified and screened. Study and population characteristics and outcomes of interest were recorded. Risk of bias assessment was performed using the Joanna Briggs Institute Critical Appraisal Tools. Results Thirteen studies were included for full review, which were primarily single‐center observational studies with retrospective or cross‐sectional designs. The diagnostic criteria and definitions used for musculoskeletal manifestations varied. Musculoskeletal manifestation prevalence ranged from 2% to 35%. Only one study assessed the response of musculoskeletal manifestations to biologics. Risk of bias demonstrated heterogeneity in study quality. Conclusion This is the first systematic review of musculoskeletal manifestations in p‐IBD. Analysis was limited because of variability in study design and data‐reporting methods. Definitions varied among included studies, with a clear lack in standardization. Our study demonstrates the need for standardized assessment of musculoskeletal manifestations of p‐IBD and further research to explore optimal management to advance care for this group of children.

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Arthritis associated with inflammatory bowel disease in children

Cited by 56 publications

References 26 publications

Enthesitis is an extraintestinal manifestation of pediatric inflammatory bowel disease

Enthesitis is an extraintestinal manifestation of pediatric inflammatory bowel disease

Relationship between Ulcerative Colitis and Rheumatoid Arthritis: A Review

Epidemiology of Musculoskeletal Manifestations in Pediatric Inflammatory Bowel Disease: A Systematic Review

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