Relationship between Ulcerative Colitis and Rheumatoid Arthritis: A Review

Abstract

Ulcerative colitis (UC) is a colonic disease characterized by chronic inflammation. Rheumatoid arthritis (RA) is a rheumatological chronic inflammatory disease characterized by joint swelling and tenderness. It is also considered an autoimmune disorder. We want to discover if a link exists between UC and RA and if so, how UC affects the progress of arthritis. We used PRISMA guidelines. In this study, we used PubMed, PubMed Central (PMC), and Google Scholar to collect data. Studies conducted more than 50 years ago, non-English articles, and animal studies were excluded. All types of studies were included. We used keywords like "ulcerative colitis", "rheumatoid arthritis", or "colitic arthritis" in the search.We identified the following sets of results: 187,611 PubMed studies, 197,610 PMC studies, and 2,282,000 Google scholar studies. After applying inclusion and exclusion criteria, the number of appropriate studies was narrowed down to 50.Arthritis is the most common complication of ulcerative UC. The radiological changes are similar to those seen in RA. There are common genes and antigens found in both diseases, such as human leukocyte antigen (HLA-B27), interleukin 15, IgA. Certain drugs used for the treatment of both disorders, including omega-3. Many studies revealed that a large number of patients with UC developed RA within a few years.All the findings prove that there is a relation between ulcerative colitis and rheumatoid arthritis. This study is useful for doctors, scientists, and patients.

Variant-to-Gene-Mapping Analyses Reveal a Role for the Hypothalamus in Genetic Susceptibility to Inflammatory Bowel Disease

“…Although primary sclerosing cholangitis also was correlated significantly with depression, we did not observe such a relationship with celiac disease and rheumatoid arthritis, despite these traits being pathologically related to IBD. 21 , 22

Figure 1 Genetic correlation estimates for 11 autoimmune diseases with depression. Numbers indicate the genetic correlation coefficients (rg) estimated with the LD-Hub test center, using precalculated LD scores.

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“…Although primary sclerosing cholangitis also was correlated significantly with depression, we did not observe such a relationship with celiac disease and rheumatoid arthritis, despite these traits being pathologically related to IBD. 21,22 Genome-Wide ATAC Sequencing and Promoter-Focused Capture C…”

Molecular hydrogen is comparable to sulfasalazine as a treatment for DSS-induced colitis in mice

“…Interestingly, there is a strong positive relationship between the inflammatory conditions of colitis and rheumatoid arthritis (Attalla et al, 2019[ 2 ]). Accordingly, the drug sulfasalazine is a standard drug for both of these inflammatory conditions (Attalla et al, 2019[ 2 ]), for which hydrogen has also been shown to be effective.…”

“…Interestingly, there is a strong positive relationship between the inflammatory conditions of colitis and rheumatoid arthritis (Attalla et al, 2019[ 2 ]). Accordingly, the drug sulfasalazine is a standard drug for both of these inflammatory conditions (Attalla et al, 2019[ 2 ]), for which hydrogen has also been shown to be effective. For example, in small clinical studies, treatment with molecular hydrogen has shown pronounced therapeutic effects in patients with rheumatoid arthritis (Ishibashi et al, 2012[ 10 ], 2014[ 11 ]).…”

Biogenic Selenium Nanoparticles: Potential Solution to Oxidative Stress Mediated Inflammation in Rheumatoid Arthritis and Associated Complications

“…Ulva lactuca polysaccharide (ULP)-coated SeNPs also showed anti-inflammation effects through the inhibition of NF-κB-mediated hyperinflammation in murine acute colitis models [ 155 ]. Given that ulcerative colitis (UC) and RA have a notable correlation [ 156 ], it can be proposed that ULP-SeNPs can be a potential therapeutic or combinational alternative for UC and RA remedial regimens. The results of the studies discussed above are shown in Table 4 .…”