Artesunate-heparin conjugate based nanocapsules with improved pharmacokinetics to combat malaria

Ismail, Muhammad; Du, Yawei; Ling, Longbing; Li, Xinsong

doi:10.1016/j.ijpharm.2019.03.031

Cited by 47 publications

(27 citation statements)

References 62 publications

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“…Moreover, common polysaccharides stated above, poly(cyclodextrin) [47], heparin [48] hyaluronan [49] and also other polysaccharides have been used to prepare nanocapsules as drug carrier for different pharmaceutic applications.…”

Section: Polymeric Shellmentioning

confidence: 99%

Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

et al. 2020

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Polymer-based nanocapsules have been widely studied as a potential drug delivery system in recent years. Nanocapsules—as one of kind nanoparticle—provide a unique nanostructure, consisting of a liquid/solid core with a polymeric shell. This is of increasing interest in drug delivery applications. In this review, nanocapsules delivery systems studied in last decade are reviewed, along with nanocapsule formulation, characterizations of physical/chemical/biologic properties and applications. Furthermore, the challenges and opportunities of nanocapsules applications are also proposed.

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Section: Polymeric Shellmentioning

confidence: 99%

Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

et al. 2020

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“…The self-assembly of amphiphilic polysaccharides in water leads to the formation of various formulations, depending on the content of hydrophobic groups covalently linked to the hydrophilic chain. Amphiphilic polysaccharides can form various structures, i.e., micelles, nanoparticles, microspheres and hydrogels that can carry both hydrophilic and hydrophobic compounds [ 79 , 80 , 81 , 82 , 83 ].…”

Section: Amphiphilic Polymers As Nanoemulsion Stabilizers: From Symentioning

confidence: 99%

Polymer Capsules with Hydrophobic Liquid Cores as Functional Nanocarriers

et al. 2020

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Recent developments in the fabrication of core-shell polymer nanocapsules, as well as their current and future applications, are reported here. Special attention is paid to the newly introduced surfactant-free fabrication method of aqueous dispersions of nanocapsules with hydrophobic liquid cores stabilized by amphiphilic copolymers. Various approaches to the efficient stabilization of such vehicles, tailoring their cores and shells for the fabrication of multifunctional, navigable nanocarriers and/or nanoreactors useful in various fields, are discussed. The emphasis is placed on biomedical applications of polymer nanocapsules, including the delivery of poorly soluble active compounds and contrast agents, as well as their use as theranostic platforms. Other methods of fabrication of polymer-based nanocapsules are briefly presented and compared in the context of their biomedical applications.

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“…A variety of nanotechnology has been developed in the past years to improve the solubility and bioavailability of ART. [23][24][25][26] ART loaded liposomes were reported with glioma targeting capabilities with enhanced toxicity towards glioma U87 cells. 27 Jin et al reported artesunate nanoliposomes, prepared with cholesterol and an appropriate amount of lecithin via thin film hydration method, showing stronger antitumor effect on HepG2 cells than that of free artesunate.…”

Section: Introductionmentioning

confidence: 99%

<p>pH-Responsive Artesunate Polymer Prodrugs with Enhanced Ablation Effect on Rodent Xenograft Colon Cancer</p>

Hao

Xie

et al. 2020

IJN

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In this study, pH-sensitive poly(2-ethyl-2-oxazoline)-poly(lactic acid)-poly(βamino ester) (PEOz-PLA-PBAE) triblock copolymers were synthesized and were conjugated with an antimalaria drug artesunate (ART), for inhibition of a colon cancer xenograft model. Methods: The as-prepared polymer prodrugs are tended to self-assemble into polymeric micelles in aqueous milieu, with PEOz segment as hydrophilic shell and PLA-PBAE segment as hydrophobic core. Results: The pH sensitivity of the as-prepared copolymers was confirmed by acid-base titration with pKb values around 6.5. The drug-conjugated polymer micelles showed high stability for at least 96 h in PBS and 37°C, respectively. The as-prepared copolymer prodrugs showed high drug loading content, with 9.57%±1.24% of drug loading for PEOz-PLA-PBAE-ART4. The conjugated ART could be released in a sustained and pH-dependent manner, with 92% of released drug at pH 6.0 and 57% of drug released at pH 7.4, respectively. In addition, in vitro experiments showed higher inhibitory effect of the prodrugs on rodent CT-26 cells than that of free ART. Animal studies also demonstrated the enhanced inhibitory efficacy of PEOz-PLA-PBAE-ART2 micelles on the growth of rodent xenograft tumor. Conclusion: The pH-responsive artesunate polymer prodrugs are promising candidates for colon cancer adjuvant therapy.

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Artesunate-heparin conjugate based nanocapsules with improved pharmacokinetics to combat malaria

Cited by 47 publications

References 62 publications

Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

Polymer Capsules with Hydrophobic Liquid Cores as Functional Nanocarriers

<p>pH-Responsive Artesunate Polymer Prodrugs with Enhanced Ablation Effect on Rodent Xenograft Colon Cancer</p>

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