Arterial transit time imaging with flow encoding arterial spin tagging (FEAST)

Wang, Danny J.J.; Alsop, David C.; Song, Hee Kwon; Maldjian, Joseph A.; Tang, Kathy Z.; Salvucci, Alana E.; Detre, John A.

doi:10.1002/mrm.10559

Cited by 245 publications

(269 citation statements)

References 22 publications

Supporting

Mentioning

259

Contrasting

Order By: Relevance

“…For each slice, the effective PLD, w, was adjusted to account for the slice acquisition time: w = (acquisition slice # -1)·(64 ms) + 800 ms. An assumption of Eq. [1] is that τ + w > δ, which we assume is satisfied in our experiment given the range of δ reported in the literature (1.0 -1.6 s) (Mildner et al, 2005;Wang et al, 2003b).…”

Section: Mri Data Processingmentioning

confidence: 55%

An investigation of statistical power for continuous arterial spin labeling imaging at 1.5 T

et al. 2008

View full text Add to dashboard Cite

Variance estimates can be used in conjunction with scientifically meaningful effect sizes to design experiments with type II error control. Here we present estimates of intra-and inter-subject variances for region of interest (ROI) from resting cerebral blood flow (CBF) maps obtained using whole brain, spin echo echoplanar (SE-EPI) continuous arterial spin labeling (CASL) imaging on 52 elderly subjects (age = 70.5 ± 7.9 years, 29 males). There was substantial intrasubject systematic variability in CBF of gray matter ROIs corresponding to a range of standard deviations = [39 -168] (mL/ (100g·min)). This variability was mainly due to two factors: 1) an expected inverse relationship between ROI volume and intrasubject variance, and 2) an increased effective post-labeling delay for more superior slices acquired later in the sequence. For example, intrasubject variance in Brodmann Area 4 (BA 4) was ∼ 8 times larger than in hippocampus, despite their similar gray matter volumes. Estimated ROI-wise power was computed for various numbers of acquired CBF images, numbers of subjects, and CBF effect sizes for two experimental designs: independent samples t-test and paired t-test. The theoretical effects of pulse sequence and field strength on general applicability of these results are discussed.

show abstract

Section: Mri Data Processingmentioning

confidence: 55%

An investigation of statistical power for continuous arterial spin labeling imaging at 1.5 T

et al. 2008

View full text Add to dashboard Cite

show abstract

“…According to the previous works, DSC MTT is different from transit time in ASL imaging. ASL transit time is defined as the duration time for the labeled blood between labeling region and brain tissue, whereas DSC MTT represents the mean time for contrast agent to traverse from the arterial to the venous end (19,29). It noted that transit time in ASL is conceptually similar with DSC Tmax.…”

Section: Fig 2 the Graphs Show The Correlations Between Asl Cbf Andmentioning

confidence: 99%

Correlation of 3D Arterial Spin Labeling and Multi-Parametric Dynamic Susceptibility Contrast Perfusion MRI in Brain Tumors

et al. 2016

View full text Add to dashboard Cite

“…ac.uk) for realignment and stereotactic normalization to an echo-planar imaging template (Montreal Neurological Institute, Montreal, Quebec, Canada; resampling size: 2 Â 2 Â 2 mm). Reconstruction of rCBF values was obtained using software implementing equation (1) in the study by Wang et al 38 The 'simple subtraction' method was used. All volumes were smoothed using an isotropic Gaussian kernel of full width half-maximum 8 mm.…”

Section: Genotypingmentioning

confidence: 99%

CYP2D6 in the brain: genotype effects on resting brain perfusion

et al. 2010

View full text Add to dashboard Cite

The cytochrome P450 2D6 (CYP2D6) is a genetically polymorphic enzyme involved in the metabolism of several psychoactive drugs. Beside its expression in the liver, CYP2D6 is highly expressed in several regions of the brain, such as the hippocampus, thalamus, hypothalamus and the cortex, but its function in the brain is not well understood. The CYP2D6 enzyme may also have a physiological role due to its involvement in neurotransmitter biotransformation. In this study, CYP2D6 genotyping was performed in N = 188 healthy individuals and compared with brain perfusion levels at rest, which may reflect an ongoing biological process regulating the reactivity of the individual to emotional stimuli and the detection of signals evoking fear. Relative to N = 42 matched extensive metabolizers, N = 14 poor metabolizers were associated with 15% higher perfusion levels in the thalamus (P = 0.03 and 0.003). Effects were also present in the whole (N = 188) sample divided into metabolizer groups, or finely graded into seven CYP2D6 activity levels. A weaker effect was observed in the right hippocampus (P = 0.05). An exploratory analysis, extended to the whole brain, suggested the involvement of CYP2D6 in regions associated with alertness or serotonergic function. These findings support the hypothesis of a functional role of CYP2D6 in the brain.

show abstract

Arterial transit time imaging with flow encoding arterial spin tagging (FEAST)

Cited by 245 publications

References 22 publications

An investigation of statistical power for continuous arterial spin labeling imaging at 1.5 T

An investigation of statistical power for continuous arterial spin labeling imaging at 1.5 T

Correlation of 3D Arterial Spin Labeling and Multi-Parametric Dynamic Susceptibility Contrast Perfusion MRI in Brain Tumors

CYP2D6 in the brain: genotype effects on resting brain perfusion

Contact Info

Product

Resources

About