An investigation of statistical power for continuous arterial spin labeling imaging at 1.5 T

Asllani, Iris; Borogovac, Ajna; Wright, Clinton B.; Sacco, Ralph L.; Brown, Truman R.; Zarahn, Eric

doi:10.1016/j.neuroimage.2007.10.015

Cited by 19 publications

(28 citation statements)

References 31 publications

(49 reference statements)

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“…Based on the coefficient of variation which was 7.9 % in the global GM ROI, we conclude that the reproducibility of our measurements lies well in the range reported for other pulsed (28)(29)(30) and continuous ASL (31)(32)(33)(34) methods. A recent multi center study at 3T including 28 sites (29) using a PASL method termed QUASAR (35,36) reported values for SD w in GM between 3.01 and 8.12 ml/100 g/min, which suggests that the reproducibility of our measurements is quite high.…”

Section: Discussionsupporting

confidence: 83%

Age‐related cerebral perfusion changes in the parietal and temporal lobes measured by pulsed arterial spin labeling

Preibisch¹,

Sorg²,

Förschler³

et al. 2011

Magnetic Resonance Imaging

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Purpose: To investigate age-related regional perfusion changes focused on the medial temporal lobes and related parietal areas using a pulsed arterial spin labeling technique. Materials and Methods:Resting cerebral blood flow (CBF) maps were obtained from 44 healthy volunteers (18 male, 26 female; age range, 19 to 79 years) using a pulsed arterial spin labeling (PASL) MRI technique at 3 Tesla focused on the parietal and temporal lobes. Repeated measurements were performed in 20 subjects to assure the reliability and reproducibility of the applied PASL technique.Results: Focal age-related CBF decreases were detected in the parietal cortex, cuneus and caudate, whereas increases were seen in the lateral and medial temporal lobe such as hippocampus, the calcarine gyrus and the thalamus. Moreover, repeated measurements demonstrated a high reliability and reproducibility of the applied PASL technique.Conclusion: Data provide evidence for regionally dissociated patterns of perfusion increases and decreases during ageing in the temporal and parietal lobes.

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Section: Discussionsupporting

confidence: 83%

Age‐related cerebral perfusion changes in the parietal and temporal lobes measured by pulsed arterial spin labeling

Preibisch¹,

Sorg²,

Förschler³

et al. 2011

Magnetic Resonance Imaging

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“…In order to visualize how much larger or smaller the inter-vendor SDΔCBF was than the intra-vendor SDΔCBF, a voxel-wise variation ratio map was created according to the following equation (Asllani et al, 2008):…”

Section: Data Analysis: Voxel-based Comparisonmentioning

confidence: 99%

Multi-vendor reliability of arterial spin labeling perfusion MRI using a near-identical sequence: Implications for multi-center studies

et al. 2015

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Introduction: A main obstacle that impedes standardized clinical and research applications of arterial spin labeling (ASL), is the substantial differences between the commercial implementations of ASL from major MRI vendors. In this study, we compare a single identical 2D gradient-echo EPI pseudo-continuous ASL (PCASL) sequence implemented on 3T scanners from three vendors (General Electric Healthcare, Philips Healthcare and Siemens Healthcare) within the same center and with the same subjects. Material and methods: Fourteen healthy volunteers (50% male, age 26.4 ± 4.7 years) were scanned twice on each scanner in an interleaved manner within 3 h. Because of differences in gradient and coil specifications, two separate studies were performed with slightly different sequence parameters, with one scanner used across both studies for comparison. Reproducibility was evaluated by means of quantitative cerebral blood flow (CBF) agreement and inter-session variation, both on a region-of-interest (ROI) and voxel level. In addition, a qualitative similarity comparison of the CBF maps was performed by three experienced neuro-radiologists. Results: There were no CBF differences between vendors in study 1 (p N 0.1), but there were CBF differences of 2-19% between vendors in study 2 (p b 0.001 in most gray matter ROIs) and 10-22% difference in CBF values obtained with the same vendor between studies (p b 0.001 in most gray matter ROIs). The inter-vendor inter-session variation was not significantly larger than the intra-vendor variation in all (p N 0.1) but one of the ROIs (p b 0.001). Conclusion: This study demonstrates the possibility to acquire comparable cerebral CBF maps on scanners of different vendors. Small differences in sequence parameters can have a larger effect on the reproducibility of ASL than hardware or software differences between vendors. These results suggest that researchers should strive to employ identical labeling and readout strategies in multi-center ASL studies.

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“…This step assumes ATT to be homogenously distributed within a slice with an initial value given to the first slice, which is then linearly incremented with superior slices. Here, this step was modeled as: ATT n = ATT 1 + 112 (n-1) ms, where: n = slice number, ATT 1 = ATT of the first slice = 200 ms (Parkes and Tofts, 2002), and 112 ms = the ATT increment per slice computed as the average of findings of Parkes and Tofts (2002) and Asllani et al (2008b).…”

Section: Assessment Of the Effect Of Att On Cbf Quantificationmentioning

confidence: 99%

“…Instead, ATT is modeled based on two main assumptions: (1) within-slice homogeneity, and (2) linear increase with superior slices (Asllani et al, 2008a;Asllani et al, 2008b;Kimura et al, 2004;Parkes et al, 2004). The effects of these assumptions on quantification of CBF are shown in Figure 2A, in which CBFd images obtained based on modeled ATT were compared with those experimentally acquired at each voxel, independently.…”

Section: Quantification Of Cbf and Regional Heterogeneity Of Attmentioning

confidence: 99%

Mapping Brain Function Using a 30-Day Interval between Baseline and Activation: A Novel Arterial Spin Labeling fMRI Approach

Borogovac

Habeck²,

Small

et al. 2010

J Cereb Blood Flow Metab

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By comparing hemodynamic signals acquired immediately before and during activation, functional magnetic resonance imaging (fMRI) is well suited for mapping acute changes in brain function. However, it remains unclear whether fMRI can map functional changes over longer periods. Here, we address this issue by empirically testing the feasibility of arterial spin labeling (ASL) fMRI to detect changes in cerebral blood flow (CBF) with baseline and task separated by 1 month. To increase the sensitivity of the method, we applied an algorithm that yielded flow density (CBFd) images that were independent of tissue content. To increase the accuracy, we developed a technique that generated arterial transit time at each voxel, independently. Results showed that activation changes in CBFd during the same session were statistically the same as across 30 days. The activation CBFd on day-30 was 34% (motor) and 25% (visual) higher than the respective baselines of 83 and 107 mL/ 100 g/min obtained on day-1. Furthermore, the signal-to-noise ratio of the CBFd measurement was 2.1 and 2.9 times higher than that of the conventional CBF for within-subject and acrosssubjects comparisons, respectively (n = 9 healthy young subjects). Taken together, these results indicate that CBFd measure could be better suited than net CBF to map long-term changes in brain function.

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An investigation of statistical power for continuous arterial spin labeling imaging at 1.5 T

Cited by 19 publications

References 31 publications

Age‐related cerebral perfusion changes in the parietal and temporal lobes measured by pulsed arterial spin labeling

Age‐related cerebral perfusion changes in the parietal and temporal lobes measured by pulsed arterial spin labeling

Multi-vendor reliability of arterial spin labeling perfusion MRI using a near-identical sequence: Implications for multi-center studies

Mapping Brain Function Using a 30-Day Interval between Baseline and Activation: A Novel Arterial Spin Labeling fMRI Approach

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