Arterial thrombotic manifestations in young women associated with the lupus anticoagulant

Borg, E. J. Ter; Meer, Jan van der; Wolf, Jtm de; Leeuwen, M. H. van; Kallenberg, Cees G. M.

doi:10.1007/bf02284060

Cited by 8 publications

(2 citation statements)

References 23 publications

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“…It should be borne in mind that lower‐limb claudication may also occur consequently to occlusion of the abdominal aorta itself, as exemplified by the cases reported by Drew et al , 20 Ter Borg et al , 21 and Hohlfeld et al ., 22 or the aorto‐iliac bifurcation 23 . McGee et al .…”

Section: Occlusions Of Aorta/aortic Bifurcationmentioning

confidence: 96%

Peripheral Vascular Occlusions Leading to Gangrene and Amputations in Antiphospholipid Antibody Positive Patients

Asherson

Cervera

Shoenfeld

2007

Annals of the New York Academy of Sciences

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Twenty-one cases from several medical centers (Brazil, Italy, Serbia, South Africa, Israel, and the United Kingdom) with severe peripheral vascular disease progressing to amputations of limbs/digits, all of whom tested positive for antiphospholipid antibodies, are documented. The patients were suffering from either systemic lupus erythematosus, discoid LE, "primary" antiphospholipid syndrome (PAPS), "lupus-like" disease, undifferentiated connective tissue disease. A high frequency of livedo reticularis preceding the arterial occlusions in our series of patients who subsequently progressed to ischemic necrosis and amputation of limbs/digits was noted. Five of the 10 patients, in whom histopathological studies had been performed, demonstrated the typical vasculopathy seen with the antiphospholipid syndrome ("APS vasculopathy"). Complicating vasculitis was present in seven of the patients. Five of the patients developed severe peripheral vascular disease during the course of the catastrophic antiphospholipid (Asherson's) syndrome.

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Section: Occlusions Of Aorta/aortic Bifurcationmentioning

confidence: 96%

Peripheral Vascular Occlusions Leading to Gangrene and Amputations in Antiphospholipid Antibody Positive Patients

Asherson

Cervera

Shoenfeld

2007

Annals of the New York Academy of Sciences

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“…During the following years, more studies on large arterial occlusions and gangrene in SLE patients with aPLs were published 102,103. In addition, an aortic arch syndrome and SLE were also observed,104-106 whereas a positive testing for aPLs was found,105 including occlusions of the abdominal aorta in aPL-positive patients 107,108. Since the first report by Hughes in 1983,109 the cerebral symptomatics in APS patients have become more and more important.…”

Section: Aps and Vaso-ischemic (Occlusive) Diseases With Neuropsychiamentioning

confidence: 99%

Antiphospholipid Syndrome and Vascular Ischemic (Occlusive) Diseases: An Overview

Atanassova

2007

Yonsei Med J

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Antiphospholipid syndrome (APS) is primarily considered to be an autoimmune pathological condition that is also referred to as "Hughes syndrome". It is characterized by arterial and/or venous thrombosis and pregnancy pathologies in the presence of anticardiolipin antibodies and/or lupus anticoagulant. APS can occur either as a primary disease or secondary to a connective tissue disorder, most frequently systemic lupus erythematosus (SLE). Damage to the nervous system is one of the most prominent clinical constellations of sequelae in APS and includes (i) arterial/venous thrombotic events, (ii) psychiatric features and (iii) other non-thrombotic neurological syndromes. In this overview we compare the most important vascular ischemic (occlusive) disturbances (VIOD) with neuro-psychiatric symptomatics, together with complete, updated classifications and hypotheses for the etio-pathogenesis of APS with underlying clinical and laboratory criteria for optimal diagnosis and disease management.

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Antiphospholipid antibodies, lupus-like disease and the “primary” antiphospholipid syndrome

Asherson

Khanashta

1989

Clin Rheumatol

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Arterial thrombotic manifestations in young women associated with the lupus anticoagulant

Cited by 8 publications

References 23 publications

Peripheral Vascular Occlusions Leading to Gangrene and Amputations in Antiphospholipid Antibody Positive Patients

Peripheral Vascular Occlusions Leading to Gangrene and Amputations in Antiphospholipid Antibody Positive Patients

Antiphospholipid Syndrome and Vascular Ischemic (Occlusive) Diseases: An Overview

Antiphospholipid antibodies, lupus-like disease and the “primary” antiphospholipid syndrome

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