2016
DOI: 10.1016/j.vph.2015.05.012
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Arterial stiffness is associated with adipokine dysregulation in non-hypertensive obese mice

Abstract: Esta es la versión de autor del artículo publicado en: This is an author produced version of a paper published in:Vascular Pharmacology 77 (2016) were observed in HFD. These data demonstrate that HFD accounts for the development of vascular remodeling and arterial stiffness associated with adipokine dysregulation and oxidative stress, independently of hypertension development.

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Cited by 24 publications
(41 citation statements)
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References 61 publications
(94 reference statements)
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“…Furthermore, we report for the first time that regular exercise increased the number of fenestrae and area occupied by fenestrae in the internal elastic lamina of the femoral artery. Our novel finding that regular exercise increased the number of fenestrae in the internal elastic lamina of femoral arteries is of relevance in light of prior findings by our group and others demonstrating that high-fat diet decreases the number of fenestrae in the internal elastic lamina of femoral 27 and mesenteric 57,58 arteries of mice. These changes in fenestration of the internal elastic lamina may be associated with changes in the elastic properties of the vessels as well as with the communication between endothelial and vascular smooth muscle cells within the vascular wall.…”
Section: Discussionsupporting
confidence: 71%
“…Furthermore, we report for the first time that regular exercise increased the number of fenestrae and area occupied by fenestrae in the internal elastic lamina of the femoral artery. Our novel finding that regular exercise increased the number of fenestrae in the internal elastic lamina of femoral arteries is of relevance in light of prior findings by our group and others demonstrating that high-fat diet decreases the number of fenestrae in the internal elastic lamina of femoral 27 and mesenteric 57,58 arteries of mice. These changes in fenestration of the internal elastic lamina may be associated with changes in the elastic properties of the vessels as well as with the communication between endothelial and vascular smooth muscle cells within the vascular wall.…”
Section: Discussionsupporting
confidence: 71%
“…Obese children exhibit worse profiles of carotid intima-media thickness, PWV and flow-mediated dilatation, reflecting vascular damage (31,32) , and several clinical and experimental obesity-related studies have found that oxidative stress is significantly associated with changes in these vascular parameters (33)(34)(35)(36) . Interestingly, in our sample, we found an unexpected positive correlation between PWV and TAS values.…”
Section: Discussionmentioning
confidence: 99%
“…Paradoxically the reduction in elastin content was also associated with a significant reduction in the area occupied by fenestrae in the IEL and a specific reduction in the number of fenestra in the IEL of arteries from offspring fed a HFD that were obtained from hyperleptinemic dams. Consumption of a HFD has been previously shown to be associated with significant reduction in the fenestrae of vessels [ 43 , 62 ]. Calculation of the elastic modulus normalized as a function of the percolation of the internal elastic lamina and its fenestrae suggests that a reduction in the number and size of fenestrae may participate in augmenting the stiffness of mesenteric arteries in animals fed a HFD [ 63 ].…”
Section: Discussionmentioning
confidence: 99%