Arterial Stiffness Assessed by Digital Volume Pulse Correlates With Comorbidity in Patients With ESRD

Sollinger, Daniel; Mohaupt, Markus; Wilhelm, Albina; Uehlinger, Dominik E.; Frey, Felix J.; Eisenberger, Ute

doi:10.1053/j.ajkd.2006.05.014

Cited by 49 publications

(52 citation statements)

References 25 publications

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“…In a study from Sollinger et al, 10 analysis of DPV showed a considerable higher failure rate and the SI could not be determined in 15 out of 97 patients (15.5%). 10 However, patients investigated in the latter were a homogeneous group with a high comorbid status of either patients on hemodialysis or renal transplant recipients, thus arterial stiffness may have progressed so far that the DPV analysis reached its technical limitation. Therefore, the high failure rate observed by Sollinger et al may not be representative for studies of heterogeneous cohorts.…”

Section: Discussionmentioning

confidence: 91%

“…10 However, data from large cohorts and a description of the feasibility of the technique compared with radial applanation tonometry in a heterogeneous population are lacking. Furthermore, it has not been thoroughly established, whether the SI accurately discriminates subjects with increased cardiovascular risk from subjects with no risk factors.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of photoplethysmographic and arterial tonometry-derived indices of arterial stiffness

et al. 2011

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Arterial tonometry is a method to assess arterial stiffness and has become a valuable tool in the stratification of cardiovascular risk. The arterial tonometry-derived augmentation index (AIx) is a marker of arterial stiffness and an independent predictor of mortality. As the AIx is relatively cumbersome to obtain, simpler methods such as analysis of pulse waves obtained by digital photoplethysmography have been proposed to estimate arterial stiffness. The objective of this study is to compare the usefulness of the stiffness index (SI) derived from digital photoplethysmography and the AIx derived from radial tonometry for stratification of cardiovascular risk. We studied 83 subjects with a heterogeneous cardiovascular risk profile and determined the ability of the two devices to differentiate subjects with low from subjects with high cardiovascular risk estimated by the Europe (EU)-heart score. Failure rate in both devices was similar (3.6%). AIx and SI were modestly correlated (r¼0.48, Po0.001) and both indexes correlated with the EU-score (r¼0.54, Po0.001) and (r¼0.56, Po0.001), respectively. Both devices discriminated accurately between subjects with high cardiovascular risk (upper tertile of the EU-score) and low cardiovascular risk (lower tertile). However, only the SI differentiated significantly between subjects with intermediate risk (middle tertile) and high risk (upper tertile). Compared with the AIx, assessment of the SI derived by digital photoplethysmography is simple and possibly yields an advantage in risk stratification of subjects with intermediate and high cardiovascular risk. Therefore, digital pulse wave analysis may be a valuable tool to estimate arterial stiffness in large clinical studies.

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Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Comparison of photoplethysmographic and arterial tonometry-derived indices of arterial stiffness

et al. 2011

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“…Furthermore, the methodological differences of arterial stiffness measurement (aortic PWV versus ASI) are likely to play a role in the discrepancies found between our and previous studies. ASI derived by finger photoplethysmography is influenced by the elasticity of the large central arteries and the properties of the reflection sites, both central and peripheral 16, 25. In addition, the PWV measured in the peripheral arteries are usually higher than the aortic PWV because of the nearer reflection sites 25.…”

Section: Discussionmentioning

confidence: 99%

“…Height (meters) was divided by the time between the peaks of the pulse waveform to obtain the ASI in m/s 15. This method has been validated by comparing it with carotid‐femoral PWV in 3 independent studies that concluded both measurements are highly correlated and that ASI is a simple, inexpensive, rapid technique that requires no training and is operator independent 9, 10, 16…”

Section: Methodsmentioning

confidence: 99%

Relationship of Arterial Stiffness Index and Pulse Pressure With Cardiovascular Disease and Mortality

Said

Eppinga

Lipšic

et al. 2018

JAHA

165

131

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BackgroundVascular aging results in stiffer arteries and may have a role in the development of cardiovascular disease (CVD). Arterial stiffness index (ASI), measured by finger photoplethysmography, and pulse pressure (PP) are 2 independent vascular aging indices. We investigated whether ASI or PP predict new‐onset CVD and mortality in a large community‐based population.Methods and ResultsWe studied 169 613 UK Biobank participants (mean age 56.8 years; 45.8% males) who underwent ASI measurement and blood pressure measurement for PP calculation. Mean±SD ASI was 9.30±3.1 m/s and mean±SD PP was 50.98±13.2 mm Hg. During a median disease follow‐up of 2.8 years (interquartile range 1.4–4.0), 18 190 participants developed CVD, of which 1587 myocardial infarction (MI), 4326 coronary heart disease, 1192 heart failure, and 1319 stroke. During a median mortality follow‐up of 6.1 years (interquartile range 5.8–6.3), 3678 participants died, of which 1180 of CVD. Higher ASI was associated with increased risk of overall CVD (unadjusted hazard ratio 1.27; 95% confidence interval [CI], 1.25–1.28), myocardial infarction (1.38; 95% CI, 1.32–1.44), coronary heart disease (1.31; 95% CI, 1.27–1.34), and heart failure (1.31; 95% CI 1.24–1.37). ASI also predicted mortality (all‐cause, CVD, other). Higher PP was associated with overall CVD (1.57; 95% CI, 1.55–1.59), myocardial infarction (1.48; 95% CI, 1.42–1.54), coronary heart disease (1.47; 95% CI, 1.43–1.50), heart failure (1.47; 95% CI, 1.40–1.55), and CVD mortality (1.47; 95% CI, 1.40–1.55). PP improved risk reclassification of CVD in a non–laboratory‐based Framingham Risk Score by 5.4%, ASI by 2.3%.Conclusions ASI and PP are independent predictors of CVD and mortality outcomes. Although both improved risk prediction for new‐onset disease, PP appears to have a larger clinical value than ASI.

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“…Arterial stiffness measured using digital volume pulse (DVP) analysis has been proved to be validated and reproducible technique with minimal intraobserver variation [7] and is a more sensitive tool in risk stratification for CVD in comparison to plasma glucose, total cholesterol, and waist to hip ratio in apparently healthy population [8].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Neutrophil-Lymphocyte Ratio and Arterial Stiffness Indices Among Young Prehypertensives: A Cross-Sectional Study

Deepika

2018

Asian J Pharm Clin Res

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Objective: The aim of the present study is to evaluate the arterial stiffness indices and neutrophil-lymphocyte ratio (NLR) in young prehypertensives.Methods: This was a cross-sectional study carried as a part of the medical health check-up program conducted on 150 students joining 1 st year MBBS. Based on their blood pressure (BP) recordings they were classified as normotensives and prehypertensives. Arterial stiffness indices were assessed using finger photoplethysmography, and NLR was evaluated using automated hematological analyzer. Student's t-test and Pearson's correlation were performed using SPSS version 16 and p<0.05 was considered as statistically significant. Results:Of the 150 subjects, 106 were recruited for the present study. Based on BP, they were grouped as normotensives (n=66) and prehypertensives (n=40). Arterial stiffness indices, namely, stiffness index (SI) and reflection index (RI) reported a significant increase among the prehypertensive group with p=0.003 and p=0.002, respectively. SI and RI showed a positive correlation with systolic BP, diastolic BP, heart rate, and body mass index (BMI). NLR reported a significant increase in a prehypertensive group with p=0.03 but no correlation was found between NLR and arterial stiffness indices. Conclusion:Targeting the high-risk individuals, based on increased arterial stiffness, NLR, BMI and BP, for earlier lifestyle modifications could act as a potential preventive strategy to inhibit the development of cardiovascular diseases.

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Arterial Stiffness Assessed by Digital Volume Pulse Correlates With Comorbidity in Patients With ESRD

Cited by 49 publications

References 25 publications

Comparison of photoplethysmographic and arterial tonometry-derived indices of arterial stiffness

Comparison of photoplethysmographic and arterial tonometry-derived indices of arterial stiffness

Relationship of Arterial Stiffness Index and Pulse Pressure With Cardiovascular Disease and Mortality

Evaluation of Neutrophil-Lymphocyte Ratio and Arterial Stiffness Indices Among Young Prehypertensives: A Cross-Sectional Study

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