Comparison of photoplethysmographic and arterial tonometry-derived indices of arterial stiffness

Clarenbach, Christian F.; Stoewhas, Anne-Christin; Gestel, Arnoldus J.R. van; Latshang, Tsogyal D.; Cascio, Christian M. Lo; Bloch, Konrad E.; Kohler, Malcolm

doi:10.1038/hr.2011.168

Cited by 39 publications

(31 citation statements)

References 25 publications

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“…Although the prognostic value of PWVcf is well established 6,8,9 and its use for cardiovascular risk assessment is recommended in clinical practice according to current guidelines, 35 SI has been associated with cardiovascular risk estimates only in few small studies. 21,22 The results of the present study showed that increasing SI and PWVcf by 2.2 m/sec (i.e. 1 SD, same for both indices) led to ca.…”

Section: Discussionmentioning

confidence: 88%

Clinical utility of digital volume pulse analysis in prediction of cardiovascular risk and the presence of angiographic coronary artery disease

Vakalis¹,

Bechlioulis²,

Naka³

et al. 2014

ARTRES

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Background: Stiffness Index (SI), assessed by finger photoplethysmography (digital volume pulse analysis), has been suggested as a simple and easy measure of arterial stiffness. However, its potential association with cardiovascular risk and coronary artery disease (CAD) has been little studied. The aims of the study were to investigate the relation of SI with classical risk factors and established arterial stiffness indices and its ability to predict cardiovascular risk and the presence of angiographic CAD. Methods: We enrolled 126 consecutive patients (mean age 61 years, 74% males) with suspected stable CAD undergoing diagnostic coronary angiography. Cardiovascular risk was assessed using Framingham risk score (FRS) and the European Heart score. Carotid-femoral (PWVcf) and carotid-radial (PWVcr) pulse wave velocity and augmentation index, using applanation tonometry, and SI using finger photoplethysmography, were measured in all patients. Results: SI was positively correlated with PWVcr (p Z 0.017) but not with PWVcf. Increased SI (R 2 0.19, p < 0.001) was independently associated with higher diastolic blood pressure and male gender. Increased SI and PWVcf were associated with higher FRS and Heart score (p < 0.05 for all), while only higher PWVcf was associated with the presence of angiographic CAD (p Z 0.007). Conclusions: SI, easily derived using finger photoplethysmography, was related to classical risk factors and peripheral arterial rather than aortic stiffness. SI and PWVcf were the only vascular indices associated with cardiovascular risk, but only PWVcf was related to the presence of

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Section: Discussionmentioning

confidence: 88%

Clinical utility of digital volume pulse analysis in prediction of cardiovascular risk and the presence of angiographic coronary artery disease

Vakalis¹,

Bechlioulis²,

Naka³

et al. 2014

ARTRES

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“…Arterial stiffness was estimated by digital volume pulse (DVP) analysis as previously described and validated (Pulse Trace® PCA 2, CareFusion, Rolle, Switzerland) [10]. The device collects 6 representative pulse waveforms with a pulse interval close to the average pulse interval.…”

Section: Methodsmentioning

confidence: 99%

Effects of Acute Exposure to Moderate Altitude on Vascular Function, Metabolism and Systemic Inflammation

et al. 2013

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BackgroundTravel to mountain areas is popular. However, the effects of acute exposure to moderate altitude on the cardiovascular system and metabolism are largely unknown.ObjectivesTo investigate the effects of acute exposure to moderate altitude on vascular function, metabolism and systemic inflammation.MethodsIn 51 healthy male subjects with a mean (SD) age of 26.9 (9.3) years, oxygen saturation, blood pressure, heart rate, arterial stiffness, lipid profiles, low density lipoprotein (LDL) particle size, insulin resistance (HOMA-index), highly-sensitive C-reactive protein and pro-inflammatory cytokines were measured at 490 m (Zurich) and during two days at 2590 m, (Davos Jakobshorn, Switzerland) in randomized order. The largest differences in outcomes between the two altitudes are reported.ResultsMean (SD) oxygen saturation was significantly lower at 2590 m, 91.0 (2.0)%, compared to 490 m, 96.0 (1.0)%, p<0.001. Mean blood pressure (mean difference +4.8 mmHg, p<0.001) and heart rate (mean difference +3.3 bpm, p<0.001) were significantly higher at 2590 m, compared to 490 m, but this was not associated with increased arterial stiffness. At 2590 m, lipid profiles improved (median difference triglycerides −0.14 mmol/l, p = 0.012, HDL +0.08 mmol/l, p<0.001, total cholesterol/HDL-ratio −0.25, p = 0.001), LDL particle size increased (median difference +0.45 nm, p = 0.048) and hsCRP decreased (median difference −0.18 mg/l, p = 0.024) compared to 490 m. No significant change in pro-inflammatory cytokines or insulin resistance was observed upon ascent to 2590 m.ConclusionsShort-term stay at moderate altitude is associated with increased blood pressure and heart rate likely due to augmented sympathetic activity. Exposure to moderate altitude improves the lipid profile and systemic inflammation, but seems to have no significant effect on glucose metabolism.Trial RegistrationClinicalTrials.gov NCT01130948

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“…The analysis of the finger PPG waveform has been used as a non-invasive method to assess arterial stiffness [12,13]. PPG is a ubiquitous optical technique, based on the measurement of changes in blood circulation in the vascular bed of a tissue.…”

Section: Introductionmentioning

confidence: 99%

Photoplethysmographic signal rising front analysis for the discrimination of subjects with increased arterial ageing

Pilt¹,

Meigas²,

Kööts³

et al. 2014

Proc. Estonian Acad. Sci.

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This study analyses the photoplethysmographic (PPG) signal waveform rising front in order to discriminate subjects with premature increase in arterial ageing. As a reference measure for the evaluation of the arterial system, the aortic augmentation index (AIx@75) was calculated using a SphygmoCor device. The study was carried out on 24 healthy subjects and 20 diabetes patients. Negative correlation relationships (r = -0.68 and r = -0.77) were found between the age and the slopes of the PPG signal. Significant differences were found between the healthy controls and diabetes patients. The highest difference between the two groups was found using the advanced signal processing algorithm for the slope calculation. The sensitivity, specificity, and accuracy of the method were 85%, 88%, and 86%, respectively. We conclude that the PPG technology with the advanced signal processing algorithm can be used for the discrimination of subjects with increased arterial ageing. This method gives the possibility to diagnose cardiovascular diseases in an early stadium.

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Comparison of photoplethysmographic and arterial tonometry-derived indices of arterial stiffness

Cited by 39 publications

References 25 publications

Clinical utility of digital volume pulse analysis in prediction of cardiovascular risk and the presence of angiographic coronary artery disease

Clinical utility of digital volume pulse analysis in prediction of cardiovascular risk and the presence of angiographic coronary artery disease

Effects of Acute Exposure to Moderate Altitude on Vascular Function, Metabolism and Systemic Inflammation

Photoplethysmographic signal rising front analysis for the discrimination of subjects with increased arterial ageing

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