Arterial spin labeling and diffusion-weighted MR imaging: Utility in differentiating idiopathic orbital inflammatory pseudotumor from orbital lymphoma

Eissa, Lamya; Razek, Ahmed Abdel Khalek Abdel; Helmy, Eman

doi:10.1016/j.clinimag.2020.10.057

Cited by 25 publications

(12 citation statements)

References 37 publications

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“…1,2 While both IOID and orbital lymphoma can have similar clinical and radiological characteristics, ADC value has proven reliable in differentiating between the two conditions, with multiple studies reporting statistically significant differences in the respective ADC values. 1,2,5,9,21,23,24,29…”

Section: Discussionmentioning

confidence: 99%

“…Mean ADC values for orbital lymphomas ranged from 0.47 to 1.25 × 10 −3 mm 2 /s among 18 studies (Table 2). 1,2,5,6,11,14,16,18,19,21–29 Sepahdari et al 6 collated the largest series of ocular adnexal lymphoma, which demonstrated a low signal on ADC maps with a mean value of 0.66 × 10 −3 mm 2 /s. Haradome et al 22 reported that an ADC threshold less than 0.612 × 10 −3 mm 2 /s yielded a sensitivity of 94.1% and specificity 93.3% for predicting lymphoma.…”

Section: Discussionmentioning

confidence: 99%

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Diagnostic Utility of Diffusion-Weighted Imaging and Apparent Diffusion Coefficient for Common Orbital Lesions: A Review

Cameron

Tong²,

Juniat³

et al. 2022

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Purpose: To review and summarize the existing literature surrounding the clinical use of diffusion-weighted imaging and apparent diffusion coefficient (ADC) as diagnostic tools in differentiating common orbital lesions. Methods: A systematic literature review on the use of ADC and diffusion-weighted imaging sequences for orbital imaging was performed. Only original research articles that reported ADC values for benign or malignant lesions were included. Results: Malignant orbital tumors have an overall lower mean ADC value than benign masses. Orbital lymphoma is characterized by consistently lower ADC values compared with other malignant orbital masses; a threshold value less than 0.775 × 10−3 mm2/s has been proposed to distinguish orbital lymphoma from other neoplastic and non-neoplastic orbital masses. To differentiate orbital inflammatory disease from lymphoma, an ADC threshold greater than 0.92 × 10−3 mm2/s has been proposed. Conclusions: Orbital masses encompass a host of benign and malignant etiologies and can present a diagnostic challenge on both clinical and radiological assessment. Recent advanced MRI techniques such as diffusion-weighted imaging and ADC can improve the diagnostic specificity for orbital disease, particularly in differentiating benign from malignant lesions and lymphoma from orbital inflammatory disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Diagnostic Utility of Diffusion-Weighted Imaging and Apparent Diffusion Coefficient for Common Orbital Lesions: A Review

Cameron

Tong²,

Juniat³

et al. 2022

Ophthalmic Plastic &Amp; Reconstructive Surgery

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“…Evidence suggests that DWI with b-values of 1500-2500 s/mm 2 are optimal for the detection of prostate cancer (19,20). At b-values of 0, 500, and 1000 s/mm 2 , there was a significant difference in tumor blood flow between patients with idiopathic orbital inflammatory pseudotumor and orbital lymphoma (21). Mean ADC value (b-values 0, 500, and 1000 s/mm 2 ) can be used for differentiation of masticator space malignancy from infection, as mean ADC value for masticator space malignancy (0.91 AE 0.21 Â 10 À3 mm 2 /s) is significantly lower than that of masticator space infection (1.59 AE 0.32 Â 10 À3 mm 2 /s) Fig.…”

Section: Discussionmentioning

confidence: 99%

The utility of diffusion-weighted imaging and ADC values in the characterization of mumps orchitis and seminoma

Liu

Jiang

et al. 2021

Acta Radiol

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Background Diffusion-weighted imaging (DWI) can quantitatively reflect the diffusion characteristics of tissues, providing a theoretical basis for qualitative diagnosis and quantitative analysis of a disease. Purpose To characterize testicular lesions that present as a hypointense signal on magnetic resonance imaging (MRI) T2-weighted images using DWI. Material and Methods Study participants were divided into three groups. Group A were healthy controls (n = 35), group B included patients with mumps orchitis (n = 20), and group C included patients with seminoma (n = 15). DWI sequences used b-values of 0, 1000, and 2000 s/mm2. Apparent diffusion coefficient (ADC) values between 1000 and 2000 s/mm2 were calculated by MRI postprocessing software. The Kruskal–Wallis test and receiver operating characteristic analysis were performed to evaluate how well ADC values distinguished between mumps orchitis and seminoma. Results Normal testicular tissue showed a hyperintense signal on DWI and hypointensity on the ADC map: mean ADC value was 0.77 (0.69–0.85) ± 0.08 ×10−3 mm2/s. Mumps orchitis and seminoma showed slight hyperintensity on DWI: mean ADC values were 0.85 (0.71–0.99) ± 0.15 ×10−3 mm2/s and 0.43 (0.39–0.47) ± 0.04 × 10−3 mm2/s, respectively. There were statistically significant differences in mean ADC values between normal testicular tissue and seminoma and between mumps orchitis and seminoma. The cutoff ADC value for differentiating seminoma from mumps orchitis was 0.54 × 10−3 mm2/s. The sensitivity, specificity, and Youden Index for diagnosing seminoma were 99%, 31%, and 30%, respectively. Conclusion High b-value DWI has potential utility for differentiating mumps orchitis from seminoma in the clinical setting.

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“…Furthermore, quantified tumor blood flow (TBF) values measured by arterial spin labeling and apparent diffusion coefficient (ADC) on diffusion-weighted imaging could be helpful in differentiating lymphoma from other expansive orbital diseases. In particular, lymphoma represents high TBF and low ADC values compared to idiopathic orbital inflammatory pseudotumors, which may be difficult to differentiate clinically [41,42]. After determining the size and location of the lesion, a histopathological examination should be performed through an open biopsy [1].…”

Section: Diagnosismentioning

confidence: 99%

Ocular adnexal mucosa-associated lymphoid tissue lymphoma: a narrative review

Chung

Son

2022

J Yeungnam Med Sci

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Lymphoma is a type of blood malignancy that begins in lymphocytes which include B-lymphocytes, T-lymphocytes, and natural killer (NK) cells. There are two main categories of lymphoma: those presenting with a specific type of cellular abnormality dubbed a Reed-Sternberg cell, called classic Hodgkin lymphomas (HLs), and the others called non-Hodgkin lymphomas (NHLs) [1]. HL accounts for approximately 10% of all lymphomas, while the remaining 90% are NHL [2]. NHL is also divided into B-cell and T-cell lymphomas. B-cell lymphoma accounts for more than 85% of all lymphoid neoplasms [1]. Although orbital lymphoma is rare, accounting for only 1% of all NHL cases, it is the most common primary orbital cancer in adults, accounting for 55% of all malignancies in the orbit [3][4][5]. The majority of NHL of the orbit and

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Arterial spin labeling and diffusion-weighted MR imaging: Utility in differentiating idiopathic orbital inflammatory pseudotumor from orbital lymphoma

Cited by 25 publications

References 37 publications

Diagnostic Utility of Diffusion-Weighted Imaging and Apparent Diffusion Coefficient for Common Orbital Lesions: A Review

Diagnostic Utility of Diffusion-Weighted Imaging and Apparent Diffusion Coefficient for Common Orbital Lesions: A Review

The utility of diffusion-weighted imaging and ADC values in the characterization of mumps orchitis and seminoma

Ocular adnexal mucosa-associated lymphoid tissue lymphoma: a narrative review

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