Arterial pulse wave velocity in relation to carotid intima-media thickness, brachial flow-mediated dilation and carotid artery distensibility: The Cardiovascular Risk in Young Finns Study and the Health 2000 Survey

Koivistoinen, Teemu; Virtanen, Marko; Hutri‐Kähönen, Nina; Lehtimäki, Terho; Jula, Antti; Juonala, Markus; Moilanen, Leena; Aatola, Heikki; Hyttinen, Jari; Viikari, Jorma; Raitakari, Olli T.; Kähönen, Mika

doi:10.1016/j.atherosclerosis.2011.08.007

Cited by 99 publications

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“…It was concluded that, with increasing age, the arterial stiffness increases [10]. In a health survey conducted by Koivistoinen et al, in 1754 participants, there was an increase in vessel stiffness variables with advancing age [11]. A similar trend was observed in our study.…”

Section: Discussionsupporting

confidence: 89%

Pulse Wave Velocity and Its Usefulness in Estimation of Hypertension

Thiruvengadam

Anburajan²

2017

Asian J Pharm Clin Res

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Objective: "Arterial vessel wall stiffness" is an important determinant of cardiovascular disease (CVD). Prolonged hypertension causes deterioration in the blood vessel elasticity. Hypertension can be prevented by early diagnosis. Pulse wave velocity (PWV) is the direct method for assessing the arterial stiffness. Though numerous studies have been performed, the definite limit is not declared to evaluate CVD based on the threshold of PWV for South Indian population. Methods:In this study, we included a total of 246 healthy controls and 14 hypertensive patients. Mechanical variables of blood flow are measured using PC-based periScope Device (Genesis Medical Systems, India). The following variables are measured from the normal controls and hypertensive patients: (i) Heart rate (bpm), (ii) systolic blood pressure (SBP) (mmHg), (iii) diastolic blood pressure (DBP) (mmHg), (iv) brachial PWV (baPWV) (cm/s), (v) carotid-femoral PWV (C-F PWV) (cm/s), (vi) pulse pressure (mm Hg), (vii) arterial stiffness index (ASI) (mmHg), (viii) anklebrachial index (ABI), (ix) aortic SBP and DBP (mmHg), and (x) aortic augmentation pressure (mmHg). Results:The study shows the deterioration in the vessel elasticity with advancing age in both men and women. In the normal men population studied (n=135), an increase in SBP from a young age to older age was 3.7%, likewise in women (n=111), it was 12%. A standard cutoff value of 1738 cm/s for baPWV and 1215 cm/s for C-F PWV was calculated from the combined group of known hypertensive patients and age-and sex-matched normal controls. Conclusion:Thus, the PWV and the variables derived from it can be used for evaluating the status of blood vessels noninvasively.

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Section: Discussionsupporting

confidence: 89%

Pulse Wave Velocity and Its Usefulness in Estimation of Hypertension

Thiruvengadam

Anburajan²

2017

Asian J Pharm Clin Res

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“…So, Kobayashi K. et al [20] and Soltesz P. et al [21] had demonstrated negative correlation between PWV and EDVD, while Nigam A. et al [22], Liang YL. et al [23] and Koivistoinen T. et al [24] had not found any relationship between these parameters. The question about correlation between PWV and IMT is also ambiguous.…”

Section: Discussionmentioning

confidence: 90%

“…Van Popele NM et al [25] and Kobayashi K et al [20] had demonstrated correlation between PWV and IMT, while Zureik M et al [27] had shown that PWV correlated with the number of atherosclerotic plaques but not with IMT. Koivistoinen T. et al [24] had reported relationship between PWV and IMT in an older group of 46-76-year-old, but found no such relationship in a group of individuals under 45 years.…”

Section: Discussionmentioning

confidence: 94%

“…[23] и Koivistoinen T. с соавт. [24] не выявили взаимосвязи меж-ду этими параметрами. Вопрос о взаимосвязи СРПВ и ТКИМ также имеет неоднозначное решение.…”

Section: Resultsunclassified

“…Koivistoinen T. с соавт. [24] выявили взаимосвязь СРПВ и ТКИМ в старшей группе лиц 46-76 лет, но не обнаружили ее в груп-пе лиц моложе 45 лет.…”

Section: Resultsunclassified

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Correlations of Different Structural and Functional Characteristics of Arterial Wall With Traditional Cardiovascular Risk Factors in Healthy People of Different Age. Part 1

Стражеско

Ткачева²,

Акашева

et al. 2016

Racionalʹnaâ farmakoterapiâ v kardiologii

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Arterial wall status is determined by several characteristics, the main of them are as follows: pulse wave velocity (PWV), carotid arteries intima-media thickness (IMT), the presence of atherosclerotic plaques, endothelium-dependent vasodilation (EDVD). When these parameters change, the risk for cardiovascular disease (CVD) grows. The nature of relationship between these indices in people without CVD clinical signs is understudied, especially in those of older age. Aim. To estimate correlations between different parameters of arterial wall in patients of different age without CVD. Material and methods. A total of 303 people aged 25-91 years without any manifestations of CVD or other chronic diseases and without regular medical treatment were examined. PWV estimation, carotid ultrasound with IMT measurement and atherosclerotic plaques amount calculation and EDVD estimation using reactive hyperemia test were performed. Results. Patients without CVD clinical signs rather often reveal arterial wall lesions already in the younger age group (mean age 40.9±8.7): reduced EDVD -in 26% of the cases, the presence of atherosclerotic plaques -in 22%, increased PWV -in 15%, increased IMT -in 8%. The prevalence of arterial wall alterations in the older age group (mean age 61.19±8.5) increase many-fold. All arterial wall parameters correlate with age. The stronger correlation was revealed between IMT and the amount of atherosclerotic plaques: r=0.46 (р<0.001) in the younger group and r=0.47 (р<0.001) in the older one. We didn't find any relationship between PWV and EDVD in the younger group and between PWV and the amount of atherosclerotic plaques in the older one. Thickened carotid intima-media increases the risk of arterial stiffness by 2.3 times. Состояние артериальной стенки определяется несколькими характеристиками, среди которых важнейшие: скорость распространения пульсовой волны (СРПВ), толщина комплекса интима-медиа сонных артерий (ТКИМ), наличие атеросклеротических бляшек (АСБ), эндотелий-зависимая вазодилятация (ЭЗВД). При их изменении возрастает риск сердечно-сосудистых заболеваний (ССЗ). Характер взаимосвязи этих показателей у людей без клинических проявлений ССЗ изучены недостаточно, особенно у лю-дей старшего возраста. Цель. Изучить особенности взаимосвязи между отдельными параметрами артериальной стенки у лиц разного возраста, не страдающих ССЗ. Материал и методы. Обследовано 303 человека в возрасте от 25 до 91 года без признаков ССЗ и других хронических заболеваний, не получавших регулярную меди-каментозную терапию. Проводилось измерение СРПВ, ультразвуковое исследование каротидных артерий для определения ТКИМ и количества АСБ. Определение ЭЗВД проводили с использованием пробы с реактивной гиперемией. Результаты. У лиц без клинических проявлений ССЗ изменения артериальной стенки встречаются достаточно часто уже в младшей группе (средний возраст 40,9±8,7 лет): сниженная ЭЗВД -у 26%, наличие АСБ -у 22%, повышенная СРПВ -у 15%, повышенная ТКИМ -у 8%. В старшей группе (средний возраст 61,1±8,5 лет) распростра-неннос...

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