Artemisinin-Resistant Malaria in Asia

Noedl, Harald; Socheat, Duong; Satimai, Wichai

doi:10.1056/nejmc0900231

Cited by 238 publications

(184 citation statements)

References 6 publications

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“…In recent years, evidence of confirmed emerging resistance to artemisinins has been gathered from clinical studies in western Cambodia as well as the bordering areas between Thailand and Myanmar [27][28][29][30] . Furthermore, the observation of pfmdr1 wild type and increasing of gene copy number may suggest declining of artesunate-mefloquine treatment efficacy in P. falciparum isolates in this border area.…”

Section: Discussionmentioning

confidence: 99%

Polymorphic patterns of pfcrt and pfmdr1 in Plasmodium falciparum isolates along the Thai-Myanmar border

Muhamad

Chai่jaroenkul

Phompradit

et al. 2013

Asian Pacific Journal of Tropical Biomedicine

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Section: Discussionmentioning

confidence: 99%

Polymorphic patterns of pfcrt and pfmdr1 in Plasmodium falciparum isolates along the Thai-Myanmar border

Muhamad

Chai่jaroenkul

Phompradit

et al. 2013

Asian Pacific Journal of Tropical Biomedicine

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“…However, strains of P. falciparum with reduced sensitivity to ACTs are emerging, especially in the ThaiCambodian border and in Bangladesh. 5,61,62 This is of great concern and highlights the urgent need for next generation antimalarial agents that target different parasite biochemical pathways. While the multistep process of haemoglobin digestion has been a notable target of antimalarial drug development over the last few decades, functional redundancy among enzymes with a similar mechanistic class (falcipains or plasmepsins) and between these classes has reduced the enthusiasm for the development of effective antimalarial agents targeting this system.…”

Section: Resultsmentioning

confidence: 99%

Anti-malaria drug development targeting the M1 alanyl and M17 leucyl aminopeptidases

Thivierge¹,

Mathew²,

Nsangou³

et al. 2012

Arkivoc

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The M1 alanyl aminopeptidase and M17 leucyl aminopeptidase are critical to the growth and development of malaria parasites inside host erythrocytes. Potent aminopeptidase inhibitors kill malaria parasites in culture and are also active in vivo against murine malaria. Functional recombinant enzyme studies have been used to decipher the three-dimensional structures of both enzymes that together with new and specific inhibitors are facilitating structure-activityrelationship (SAR) and functional studies. Here we review the progress made in our knowledge of these two enzymes which is bringing them closer to being validated anti-malarial drug targets.

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“…Starting artemisinin resistance in Southeast Asia has begun to threaten the use of ACTs [19,20]. Research in optimising the use of these drugs is likely to yield high gains at relatively low costs over the next 5-10 years.…”

Section: New Drugs: Dihydroartemisinin-piperaquine and Fosmidomycinmentioning

confidence: 99%

Highlights of a Symposium, Malaria: Where are we Today, Where are we Going?

Wieten

Vugt

Leth

et al. 2011

TOIDJ

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Malaria continues to pose a major public health threat in endemic areas. However, times are changing, and many investments have been made in recent years into funding of malaria research, the development of more and improved control tools, and applying those to the field. Consequently, there is a renewed interest in going as far as considering the prospects of malaria elimination on a global scale. This goal cannot be reached without optimising and combining biotechnical, economical and social anthropological aspects. A symposium held on 25 January 2011 in Amsterdam, the Netherlands, organised by the Amsterdam Institute for Global Health and Development, the Center for Infection and Immunity Amsterdam and the Academic Medical Center of the University of Amsterdam, focused on malaria and the malERA eradication program, summarizing the state of the art in malaria control and beyond, and offering insight into the various possible ways forward. This manuscript summarizes the information presented and the ensuing discussions.

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Artemisinin-Resistant Malaria in Asia

Cited by 238 publications

References 6 publications

Polymorphic patterns of pfcrt and pfmdr1 in Plasmodium falciparum isolates along the Thai-Myanmar border

Polymorphic patterns of pfcrt and pfmdr1 in Plasmodium falciparum isolates along the Thai-Myanmar border

Anti-malaria drug development targeting the M1 alanyl and M17 leucyl aminopeptidases

Highlights of a Symposium, Malaria: Where are we Today, Where are we Going?

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