Arsphenamine-Resistant Syphilis

Netherton, E. W.

doi:10.1001/archderm.1937.01470220047005

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1942

2023

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Cited by 4 publications

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“…Antimicrobial resistance (AMR) is an evolutionary response of microbes to withstand the onslaught of antimicrobial agents introduced into their environment. This response has been stocking up in human bacterial pathogens since the beginning of the modern antimicrobial era, marked in 1910 by the introduction of arsphenamine (Salvarsan) into clinical use to treat syphilis cases in humans (Netherton, 1937). Twenty years later, the discovery of sulfonamido-chrysoidine (Prontosil) and development of sulfonamides (1932)(1933)(1934)(1935)(1936)(1937)(1938) was a turning point in the war against bacterial infections (Bickel, 1988).…”

Section: Introductionmentioning

confidence: 99%