Insights into the genetic contexts of sulfonamide resistance among early clinical isolates of Acinetobacter baumannii

Bala, Anju; Uhlin, Bernt Eric; Karah, Nabil

doi:10.1016/j.meegid.2023.105444

Cited by 1 publication

(2 citation statements)

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“…This can be elucidated by the robust association of the sul1 gene with class 1 integrons. Meanwhile, sul2 acquisitions are mediated by plasmids and transposons [31,32]. * Draft genome length was obtained using short-read sequencing.…”

Section: Detection Of Antimicrobial Resistant Genes (Args) From Acine...mentioning

confidence: 99%

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Genomic Characterization of Mobile Genetic Elements Associated with Multidrug-Resistant Acinetobacter Non-baumannii Species from Southern Thailand

Yaikhan,

Chukamnerd,

Singkhamanan

et al. 2024

Antibiotics

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This study investigated the genetic diversity, antimicrobial resistance profiles, and virulence characteristics of Acinetobacter non-baumannii isolates obtained from four hospitals in southern Thailand. Clinical data, genome information, and average nucleotide identity (ANI) were analyzed for eight isolates, revealing diverse genetic profiles and novel sequence types (STs). Minimum spanning tree analysis indicated potential clonal spread of certain STs across different geographic regions. Antimicrobial resistance genes (ARGs) were detected in all isolates, with a high prevalence of genes conferring resistance to carbapenems, highlighting the challenge of antimicrobial resistance in Acinetobacter spp. infections. Mobile genetic elements (MGEs) carrying ARGs were also identified, emphasizing the role of horizontal gene transfer in spreading resistance. Evaluation of virulence-associated genes revealed a diverse range of virulence factors, including those related to biofilm formation and antibiotic resistance. However, no direct correlation was found between virulence-associated genes in Acinetobacter spp. and specific clinical outcomes, such as infection severity or patient mortality. This complexity suggests that factors beyond gene presence may influence disease progression and outcomes. This study emphasizes the importance of continued surveillance and molecular epidemiological studies to combat the spread of multidrug-resistant (MDR) Acinetobacter non-baumannii strains. The findings provide valuable insights into the epidemiology and genetic characteristics of this bacteria in southern Thailand, with implications for infection control and antimicrobial management efforts.

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Section: Detection Of Antimicrobial Resistant Genes (Args) From Acine...mentioning

confidence: 99%

“…This can be elucidated by the robust association of the sul1 gene with class 1 integrons. Meanwhile, sul2 acquisitions are mediated by plasmids and transposons [31,32]. β-lactams, especially carbapenems, are in the broadest spectrum for the treatment of Acinetobacter spp.…”

Section: Detection Of Antimicrobial Resistant Genes (Args) From Acine...mentioning

confidence: 99%

Genomic Characterization of Mobile Genetic Elements Associated with Multidrug-Resistant Acinetobacter Non-baumannii Species from Southern Thailand

Yaikhan,

Chukamnerd,

Singkhamanan

et al. 2024

Antibiotics

View full text Add to dashboard Cite

show abstract

Insights into the genetic contexts of sulfonamide resistance among early clinical isolates of Acinetobacter baumannii

Cited by 1 publication

References 47 publications

Genomic Characterization of Mobile Genetic Elements Associated with Multidrug-Resistant Acinetobacter Non-baumannii Species from Southern Thailand

Genomic Characterization of Mobile Genetic Elements Associated with Multidrug-Resistant Acinetobacter Non-baumannii Species from Southern Thailand

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