Arsenic-induced developmental defects and mitotic abnormalities in sea-urchin development

Pagano, Giovanni; Esposito, A.; Bove, Patrizia; Angelis, Marialuisa de; Rota, Annamaria; Vamvakinos, Evangelos; Giordano, Giovan Giacomo

doi:10.1016/0165-7992(82)90168-3

Cited by 29 publications

(22 citation statements)

References 2 publications

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“…A previous study by Pagano et al [15] showed that embryos exposed to 0.75 mg/L presented 40% gastrula and prism stages, pathologic blastulae, and inhibition of skeletal development. A previous study by Pagano et al [15] showed that embryos exposed to 0.75 mg/L presented 40% gastrula and prism stages, pathologic blastulae, and inhibition of skeletal development.…”

Section: Developmental Defectsmentioning

confidence: 91%

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Toxicity of Heavy Metals Using Sperm Cell and Embryo Toxicity Bioassays With Paracentrotus Lividus (Echinodermata: Echinoidea): Comparisons With Exposure Concentrations in the Lagoon of Venice, Italy

Novelli¹,

Losso²,

Ghetti³

et al. 2003

Environ Toxicol Chem

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Sperm cell and embryo toxicity tests using the Mediterranean sea urchin Paracentrotus lividus Lmk were performed to assess the toxicity of As3+, Cd2+, Cr3+, Ni2+, Pb2+, Cu2+, Zn2+, and Hg2+. The aim of this study was to improve information about the comparative sensitivity of sea urchin bioassays to the heavy metals, which are an important cause of contamination in the ecosystem of the Lagoon of Venice. Considering the data in mM/L, the order of toxicity is Hg2+ > Cu2+ > Zn2+ > As3+ > or = Cr3+ > or = Cd2+ > or = Pb2+ > or = Ni2+ for the sperm cell test and Hg2+ > or = Pb2+ > Cu2+ > Zn2+ > Cd2+ > Ni2+ > As3+ > or = Cr3+ for the embryo test. New toxicity data for metals expressed as median effective concentration (EC50) and no-observed-effect concentration (NOEC) are reported for the Mediterranean species. Accurate observations of embryotoxic effects at increasing metal concentrations were done, detecting some different behaviors in metal toxicity. Toxicity data compared with water column and pore-water concentrations recorded in the Lagoon of Venice (Italy) demonstrate the potential ability of bioassays using sea urchin to detect important contaminants in this ecosystem.

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Section: Developmental Defectsmentioning

confidence: 91%

“…They discuss specific investigations of one or few metals [14][15][16][17][18] or toxicity test one at a time [19][20][21][22][23]. Many studies concerning sensitivity of sea urchin bioassays to heavy metals as pure substances have been published.…”

Section: Introductionmentioning

confidence: 99%

Toxicity of Heavy Metals Using Sperm Cell and Embryo Toxicity Bioassays With Paracentrotus Lividus (Echinodermata: Echinoidea): Comparisons With Exposure Concentrations in the Lagoon of Venice, Italy

Novelli¹,

Losso²,

Ghetti³

et al. 2003

Environ Toxicol Chem

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“…Other parameters are represented by enzymes related to detoxification, inflammation and neurotoxicity (e.g. ChE activities, Falugi et al, ; Falugi and Aluigi, ), and genomic markers by analyzing genes and transcripts (Aluigi et al, ) or gene alterations (Pagano et al, ). The same biomarkers have been used for assessing NPs risk.…”

Section: Introductionmentioning

confidence: 99%

Review: Morphofunctional and biochemical markers of stress in sea urchin life stages exposed to engineered nanoparticles

Gambardella

Ferrando

Gatti³

et al. 2015

Environmental Toxicology

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We describe the use of different life stages of the Mediterranean sea urchin Paracentrotus lividus for the assessment of the possible risk posed by nanoparticles (NPs) in the coastal water. A first screening for the presence of NPs in sea water may be obtained by checking their presence inside tissues of organisms taken from the wild. The ability of NPs to pass from gut to the coelomic fluid is demonstrated by accumulation in sea urchin coelomocytes; the toxicity on sperms can be measured by embryotoxicity markers after sperm exposure, whereas the transfer through the food chain can be observed by developmental anomalies in larvae fed with microalgae exposed to NPs. The most used spermiotoxicity and embryotoxicity tests are described, as well as the biochemical and histochemical analyses of cholinesterase (ChE) activities, which are used to verify toxicity parameters such as inflammation, neurotoxicity, and interference in cell-to-cell communication. Morphological markers of toxicity, in particular skeletal anomalies, are described and classified. In addition, NPs may impair viability of the immune cells of adult specimens. Molecular similarity between echinoderm and human immune cells is shown and discussed. © 2015 Wiley Periodicals, Inc. Environ Toxicol 31: 1552-1562, 2016.

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“…Therefore, estimations of the teratogenic potential of arsenic rely almost entirely on experimental studies. In nonmammalian species, developmental defects and mitotic abnormalities have been observed in seaurchins after treatment of the gametes and embryos with sodium arsenite and sodium arsenate (Pagano et al 1982). In chicks, inorganic arsenic elicited stunting, micromelia, abdominal edema, and dose-related death (Birge and Roberts 1976), and methylarsenate caused spina bifida (Ancel 1946).…”

Section: Teratogenic Effectsmentioning

confidence: 99%

Arsenic

Stoeppler¹

2004

Elements and Their Compounds in the Environment

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Arsenic-induced developmental defects and mitotic abnormalities in sea-urchin development

Cited by 29 publications

References 2 publications

Toxicity of Heavy Metals Using Sperm Cell and Embryo Toxicity Bioassays With Paracentrotus Lividus (Echinodermata: Echinoidea): Comparisons With Exposure Concentrations in the Lagoon of Venice, Italy

Toxicity of Heavy Metals Using Sperm Cell and Embryo Toxicity Bioassays With Paracentrotus Lividus (Echinodermata: Echinoidea): Comparisons With Exposure Concentrations in the Lagoon of Venice, Italy

Review: Morphofunctional and biochemical markers of stress in sea urchin life stages exposed to engineered nanoparticles

Arsenic

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