Arsenic-induced changes in certain neurotransmitter levels and their recoveries following chelation in rat whole brain

Tripathi, Neelima; Kannan, G. M.; Pant, B. P.; Jaiswal, Devendra K.; Malhotra, P. R.; Flora, Swaran J.S.

doi:10.1016/s0378-4274(97)00058-1

Cited by 82 publications

(46 citation statements)

References 26 publications

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“…In our study decreased levels of 5-HT were observed in different brain regions of arsenic-treated rats at low doses, however, changes were insignificant. Our findings are in agreement, even at a high dose of arsenic with those of Tripathi et al [33]. The differential changes in the level of biogenic amines and their metabolites in different brain regions were found might be due to the different duration of exposure and different sensitive period of exposure.…”

Section: Discussionsupporting

confidence: 93%

“…Therefore, studying the impairment of biogenic amine and their metabolites in the brain of rats is extremely considerable to understand the developmental neurotoxicity of arsenic. Developmental exposure to arsenic affects the release, synthesis, uptake of neurotransmitter and receptor expression could be deleterious and lead to long-term behavioral deficits [32][33][34]. Levels of some neurotransmitters and the activity of enzymes related to neurotransmitter metabolism, such as cholinesterase and dopamine b-hydroxylase, in the brain of rodents were found to be altered after exposure to arsenic [34][35][36][37].…”

Section: Introductionmentioning

confidence: 99%

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Subchronic Early Life Arsenic Exposure at Low Doses Impaired the Biogenic Amine Neurotransmitter and Nitric Oxide Levels in Different Brain Regions of Rats

Chandravanshi¹,

Patel²

2017

J Environ Anal Toxicol

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Subchronic Early Life Arsenic Exposure at Low Doses Impaired the Biogenic Amine Neurotransmitter and Nitric Oxide Levels in Different Brain Regions of Rats

Chandravanshi¹,

Patel²

2017

J Environ Anal Toxicol

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“…Metal chelators are currently widely used to chelate iron and copper overload in diverse patients. Several studies have shown that chelation prevents the deleterious effects of metal accumulation in the organism [147][148][149][150], including male reproductive system, suggesting its potential for the protection against disorders during metal overload.…”

Section: Chelation Therapymentioning

confidence: 99%

Iron and copper in male reproduction: a double-edged sword

Tvrdá

Peer

Sikka

et al. 2014

J Assist Reprod Genet

150

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Iron and copper are essential trace nutrients playing important roles in general health and fertility. However, both elements are highly toxic when accumulating in large quantities. Their direct or indirect impact on the structure and function of male gonads and gametes is not completely understood yet. Excess or deficiency of either element may lead to defective spermatogenesis, reduced libido, and oxidative damage to the testicular tissue and spermatozoa, ultimately leading to fertility impairment. This review will detail the complex information currently available on the dual roles iron and copper play in male reproduction.

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“…The inhibitory action of arsenic on AChE is rather poorly studied (Tripathi et al 1997;Stoytcheva et al 1998). Arsenite is a well-known and potent inhibitor of enzymes that contain lipoic acid; the mechanism of inhibition is the formation of a cyclic dithioarsenite diester.…”

Section: The Effect Of Arsenic In Fishmentioning

confidence: 99%

Arsenic-induced responses in freshwater teleosts

Bhattacharya

Roy

2007

Fish Physiol Biochem

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The environment is currently polluted by thousands of chemicals or xenobiotics introduced into the environment by man to meet the demands of the modern era. Every day we encounter this negative side of human civilization, but have done little to lessen the rate of pollution. Although the entire biosphere is polluted it is water resources that are the most polluted because water is the ultimate sink for many contaminants. Thus, fish are the most vulnerable of all animal species. They are helpless because they cannot avoid the polluted habitat and face this contamination by default. Nevertheless, fish are found to survive under extreme conditions when their natural habitat has been compromised to a great extent. However, fish are highly sensitive to small environmental changes and their populations gradually dwindle if pollution continues unabated. However, we know that there are instances when water is cleaned and the rate of repopulation by different fish species has gained momentum, restoring the ecological balance. Thus, fish are considered reliable bioindicators of water pollution and fish ecotoxicology has received much attention in recent years, and fish toxicology has been able to defend a significant position in the arena of xenobiotics research over the years. This review deals with some of the major intoxication and detoxication signals manifested by fish exposed to arsenic (As), which is presently one of the most worrying metalloids in water pollution.

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Arsenic-induced changes in certain neurotransmitter levels and their recoveries following chelation in rat whole brain

Cited by 82 publications

References 26 publications

Subchronic Early Life Arsenic Exposure at Low Doses Impaired the Biogenic Amine Neurotransmitter and Nitric Oxide Levels in Different Brain Regions of Rats

Subchronic Early Life Arsenic Exposure at Low Doses Impaired the Biogenic Amine Neurotransmitter and Nitric Oxide Levels in Different Brain Regions of Rats

Iron and copper in male reproduction: a double-edged sword

Arsenic-induced responses in freshwater teleosts

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