Arsenic exposure induced anxiety-like behaviors in male mice via influencing the GABAergic Signaling in the prefrontal cortex

Hu, Xin; Yuan, Xianglin; Yang, Mingyu; Han, Maoan; Ommati, Mohammad Mehdi; Ma, Yanqin

doi:10.1007/s11356-023-28426-8

Cited by 6 publications

(3 citation statements)

References 58 publications

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“…In the open field experiment, the residence time and movement distance in the central area of the rats served as indicators of their curiosity towards the new environment [ 27 ]. Although the exploratory abilities of the arsenic-exposed rats in this study showed a decrease, the difference compared to the control group was not statistically significant.…”

Section: Discussionmentioning

confidence: 99%

“…Taheri et al conducted a similar open field experiment on adult Wistar rats exposed to arsenic, revealing a reduced total distance and movement speed in the arsenic-exposed rats; however, their study did not mention the residence time and movement distance in the central region [ 12 ]. Previous investigations have reported significant reductions in both movement distance and residence time in the central region, for C57BL/6 male mice exposed to arsenic trioxide and female offspring mice exposed to sodium arsenite [ 27 , 28 ]. However, there are discrepancies in terms of species and arsenic exposure doses between the aforementioned studies and the current investigation.…”

Section: Discussionmentioning

confidence: 99%

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Subchronic Arsenic Exposure Induces Behavioral Impairments and Hippocampal Damage in Rats

Chu,

Yang,

et al. 2023

Toxics

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This study investigated the effects of subchronic arsenic exposure on behavior, neurological function, and hippocampal damage in rats. Thirty-two male Wistar rats were divided into four groups and exposed to different concentrations of arsenic in their drinking water for 12 weeks, while weekly water intake and body weight were recorded. Various neurobehavioral tests were conducted, evaluating overall activity levels, exploratory behavior, short-term memory, spatial learning and memory, anxiety-like behavior, and depressive-like states. Arsenic levels in urine, serum, and brain tissue were measured, and histopathological analysis assessed hippocampal damage using hematoxylin and eosin staining. The results demonstrated that arsenic exposure did not significantly affect overall activity or exploratory behavior. However, it impaired short-term memory and spatial learning and memory functions. Arsenic-exposed rats exhibited increased anxiety-like behavior and a depressive-like state. Arsenic levels increased dose-dependently in urine, serum, and brain tissue. The histopathological examinations revealed significant hippocampal damage, including neuronal shrinkage, cell proliferation, irregular structure, disordered arrangement, and vacuolation. These findings emphasize the importance of understanding the impact of arsenic exposure on behavior and brain health, highlighting its potential neurological consequences.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Subchronic Arsenic Exposure Induces Behavioral Impairments and Hippocampal Damage in Rats

Chu,

Yang,

et al. 2023

Toxics

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“…Conversely, using a different approach, when As exposure occurred during adulthood through diet, glutamate increased in the motor cortex, striatum, nucleus accumbens, and hippocampus; GABA levels were reduced in the striatum, cerebellum, and brainstem; and GAD activity was reduced in the hippocampus, hypothalamus, and cerebellum [271]. According with these findings, Hu and coworkers recently reported that sub-chronic As exposure induces a reduction in the expression of both GAD and GABA B2 receptors in the prefrontal cortex correlated with anxiety-like behaviors [272].…”

Section: Neurochemical Dysfunction Induced By Arsenic Exposurementioning

confidence: 94%

Mechanisms Associated with Cognitive and Behavioral Impairment Induced by Arsenic Exposure

Vázquez Cervantes,

González Esquivel,

Ramírez Ortega

et al. 2023

Cells

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Arsenic (As) is a metalloid naturally present in the environment, in food, water, soil, and air; however, its chronic exposure, even with low doses, represents a public health concern. For a long time, As was used as a pigment, pesticide, wood preservative, and for medical applications; its industrial use has recently decreased or has been discontinued due to its toxicity. Due to its versatile applications and distribution, there is a wide spectrum of human As exposure sources, mainly contaminated drinking water. The fact that As is present in drinking water implies chronic human exposure to this metalloid; it has become a worldwide health problem, since over 200 million people live where As levels exceed safe ranges. Many health problems have been associated with As chronic exposure including cancer, cardiovascular diseases, gastrointestinal disturbances, and brain dysfunctions. Because As can cross the blood–brain barrier (BBB), the brain represents a target organ where this metalloid can exert its long-term toxic effects. Many mechanisms of As neurotoxicity have been described: oxidative stress, inflammation, DNA damage, and mitochondrial dysfunction; all of them can converge, thus leading to impaired cellular functions, cell death, and in consequence, long-term detrimental effects. Here, we provide a current overview of As toxicity and integrated the global mechanisms involved in cognitive and behavioral impairment induced by As exposure show experimental strategies against its neurotoxicity.

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GABAergic implications in anxiety and related disorders

Arora,

Mal,

Arora

et al. 2024

Biochemical and Biophysical Research Communications

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Arsenic exposure induced anxiety-like behaviors in male mice via influencing the GABAergic Signaling in the prefrontal cortex

Cited by 6 publications

References 58 publications

Subchronic Arsenic Exposure Induces Behavioral Impairments and Hippocampal Damage in Rats

Subchronic Arsenic Exposure Induces Behavioral Impairments and Hippocampal Damage in Rats

Mechanisms Associated with Cognitive and Behavioral Impairment Induced by Arsenic Exposure

GABAergic implications in anxiety and related disorders

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