Arsenic Exposure Decreases Adiposity During High‐Fat Feeding

Carmean, Christopher M.; Kirkley, Andrew G.; Landeche, Michael; Ye, Honggang; Chellan, Bijoy; Aldirawi, Hani; Roberts, Austin A.; Parsons, Patrick J.; Sargis, Robert M.

doi:10.1002/oby.22770

Cited by 18 publications

(12 citation statements)

References 39 publications

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“…Correspondingly, prolonged exposure of adult C57BL/6J female mice to inorganic As (5–20 ppm in drinking water for 17 weeks) was shown to impair energy homeostasis, resulting in metabolic disturbances attributed to BAT whitening and impaired thermogenesis 51 . These findings corroborate data on As-induced alteration of mitochondrial biogenesis and beige adipocyte formation, indicative of the significant role of reduced thermogenesis in the observed increase in adiposity 40 .…”

Section: Adipotropic Effects Of Heavy Metalssupporting

confidence: 90%

“…Specifically, exposure to As-containing drinking water (300 μg/L sodium arsenite [NaAsO 2 ]) for 9 weeks in male C57BL/6J mice resulted in a significant increase in WAT mass, accompanied by impaired mitochondrial biogenesis and thermogenesis due to modulation of PPARα and PPARγ-specific genes, including Slc27a2 , Fabp3 , Ucp1 , Acsl5 , Scd2 , and Cpt1β 39 . However, exposure to a higher dose (50 mg/L for 16 weeks) significantly reduced adipose tissue mass in HFD-fed male C57BL/6J mice without alteration of energy expenditure as assessed by indirect calorimetry 40 . The authors propose that the observed “antiobesogenic” effect of As could be attributed to its insulin-sensitizing activity 40 .…”

Section: Adipotropic Effects Of Heavy Metalsmentioning

confidence: 91%

“…However, exposure to a higher dose (50 mg/L for 16 weeks) significantly reduced adipose tissue mass in HFD-fed male C57BL/6J mice without alteration of energy expenditure as assessed by indirect calorimetry 40 . The authors propose that the observed “antiobesogenic” effect of As could be attributed to its insulin-sensitizing activity 40 . Of interest, an inverse association between As dose and adipogenic response was reported by Shearer et al .…”

Section: Adipotropic Effects Of Heavy Metalsmentioning

confidence: 91%

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Adipotropic effects of heavy metals and their potential role in obesity

Tinkov¹,

Aschner²,

Tao³

et al. 2021

Fac Rev

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Epidemiological studies demonstrated an association between heavy metal exposure and the incidence of obesity and metabolic syndrome. However, the particular effects of metal toxicity on adipose tissue functioning are unclear. Therefore, recent findings of direct influence of heavy metals (mercury, cadmium, and lead) and metalloid (arsenic) on adipose tissue physiology are discussed while considering existing gaps and contradictions. Here, we provide a literature review addressing adipose tissue as a potential target of heavy metal toxicity. Experimental in vivo studies demonstrated a significant influence of mercury, cadmium, lead, and arsenic exposure on body adiposity. In turn, in vitro experiments revealed both up- and downregulation of adipogenesis associated with aberrant expression of key adipogenic pathways, namely CCAAT/enhancer-binding protein (C/EBP) and peroxisome proliferator-activated receptor gamma (PPARγ). Comparison of the existing studies on the basis of dose and route of exposure demonstrated that the effects of heavy metal exposure on adipose tissue may be dose-dependent, varying from increased adipogenesis at low-dose exposure to inhibition of adipose tissue differentiation at higher doses. However, direct dose-response data are available in a single study only for arsenic. Nonetheless, both types of these effects, irrespective of their directionality, contribute significantly to metabolic disturbances due to dysregulated adipogenesis. Particularly, inhibition of adipocyte differentiation is known to reduce lipid-storage capacity of adipose tissue, leading to ectopic lipid accumulation. In contrast, metal-associated stimulation of adipogenesis may result in increased adipose tissue accumulation and obesity. However, further studies are required to reveal the particular dose- and species-dependent effects of heavy metal exposure on adipogenesis and adipose tissue functioning.

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Section: Adipotropic Effects Of Heavy Metalssupporting

confidence: 90%

Section: Adipotropic Effects Of Heavy Metalsmentioning

confidence: 91%

Section: Adipotropic Effects Of Heavy Metalsmentioning

confidence: 91%

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Adipotropic effects of heavy metals and their potential role in obesity

Tinkov¹,

Aschner²,

Tao³

et al. 2021

Fac Rev

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“…We hypothesized that we might observe protective effects of arsenic on HOMA-IR in women with the highest arsenic concentrations. This was based on recent mouse models that have shown that at higher levels of exposure, arsenic may improve insulin resistance which may offset arsenic-induced impairment in beta-cell function [ 44 – 46 ]. Our spline models were somewhat consistent with these rodent data.…”

Section: Discussionmentioning

confidence: 99%

Arsenic exposure during pregnancy and postpartum maternal glucose tolerance: evidence from Bangladesh

et al. 2022

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Background Arsenic exposure has been associated with gestational diabetes mellitus. However, the extent to which arsenic exposure during pregnancy is associated with postpartum glucose intolerance is unknown. Methods We studied 323 women in Bangladesh. We assessed arsenic exposure in early pregnancy via toenail and water samples. We measured fasting glucose and insulin in serum at a mean (SD) of 4.0 (3.5) weeks post-delivery. We ran covariate-adjusted, linear regression models to examine associations of arsenic concentrations with HOMA-IR, a marker of insulin resistance, and HOMA-β, a marker of beta cell function. Results Median (IQR) arsenic concentration was 0.45 (0.67) μg/g in toenails and 2.0 (6.5) μg/L in drinking water. Arsenic concentrations during pregnancy were not associated with insulin resistance or beta cell function postpartum. HOMA-IR was 0.07% (− 3.13, 3.37) higher and HOMA-β was 0.96% (− 3.83, 1.99) lower per IQR increment in toenail arsenic, but effect estimates were small and confidence intervals crossed the null. Conclusions Although arsenic exposure during pregnancy has been consistently associated with gestational diabetes mellitus, we found no clear evidence for an adverse effect on postpartum insulin resistance or beta cell function.

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“…Studies in animal models have revealed arsenic’s multi-organ effects on glucose homeostasis [ 14 , 15 , 16 , 17 ], confirming its role as an endocrine-disrupting chemical (EDC). Though it is widely recognized that arsenic decreases β-cell function [ 17 , 18 , 19 , 20 , 21 ] and alters insulin sensitivity [ 22 , 23 , 24 , 25 ], the molecular mechanisms responsible for these effects, and their exact relevance to human health, remain poorly understood [ 18 , 20 , 26 , 27 , 28 , 29 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

Dietary Selenium Deficiency Partially Mimics the Metabolic Effects of Arsenic

et al. 2021

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Chronic arsenic exposure via drinking water is associated with diabetes in human pop-ulations throughout the world. Arsenic is believed to exert its diabetogenic effects via multiple mechanisms, including alterations to insulin secretion and insulin sensitivity. In the past, acute arsenicosis has been thought to be partially treatable with selenium supplementation, though a potential interaction between selenium and arsenic had not been evaluated under longer-term exposure models. The purpose of the present study was to explore whether selenium status may augment arsenic’s effects during chronic arsenic exposure. To test this possibility, mice were exposed to arsenic in their drinking water and provided ad libitum access to either a diet replete with selenium (Control) or deficient in selenium (SelD). Arsenic significantly improved glucose tolerance and decreased insulin secretion and β-cell function in vivo. Dietary selenium deficiency resulted in similar effects on glucose tolerance and insulin secretion, with significant interactions between arsenic and dietary conditions in select insulin-related parameters. The findings of this study highlight the complexity of arsenic’s metabolic effects and suggest that selenium deficiency may interact with arsenic exposure on β-cell-related physiological parameters.

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Arsenic Exposure Decreases Adiposity During High‐Fat Feeding

Cited by 18 publications

References 39 publications

Adipotropic effects of heavy metals and their potential role in obesity

Adipotropic effects of heavy metals and their potential role in obesity

Arsenic exposure during pregnancy and postpartum maternal glucose tolerance: evidence from Bangladesh

Dietary Selenium Deficiency Partially Mimics the Metabolic Effects of Arsenic

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