Arsenic exposure during pregnancy and postpartum maternal glucose tolerance: evidence from Bangladesh

Fleisch, Abby F.; Mukherjee, Sudipta Kumer; Biswas, Subrata Kumar; Obrycki, John F.; Ekramullah, Sheikh Muhammad; Arman, DM; Islam, Joynul; Christiani, David C.; Mazumdar, Maitreyi

doi:10.1186/s12940-021-00811-1

Cited by 11 publications

(3 citation statements)

References 48 publications

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“…The burden of cardiovascular disease attributable to arsenic in drinking water significantly impacts young and healthy women [ 38 , 39 , 83 ]. In a Bangladesh cohort, there was no clear evidence for an effect of arsenic exposure during pregnancy, on postpartum insulin resistance or beta cell function, in contrast to what has been described in the literature [ 84 ].…”

Section: Reviewmentioning

confidence: 99%

Maternal Exposure to Arsenic and Its Impact on Maternal and Fetal Health: A Review

Ortiz-Garcia,

Cipriano Ramírez,

Juarez

et al. 2023

Cureus

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Arsenic exposure is a significant public health issue, with harmful effects caused by its use in commercial products such as car batteries, pesticides, and herbicides. Arsenic has three main compounds: inorganic, organic, and arsine gas. Inorganic arsenic compounds in water are highly toxic. The daily intake of arsenic from food and beverages is between 20 and 300 mcg/day. Arsenic is known for its carcinogenic properties and is classified as a human carcinogen by different institutions. Exposure can lead to oxidative stress, DNA damage, and epigenetic deregulation, which can cause endocrine disorders, altered signal transduction pathways, and cell proliferation. In addition, arsenic can easily cross the placenta, making it a critical concern for maternal and fetal health. Exposure can lead to complications such as gestational diabetes, anemia, low birth weight, miscarriage, and congenital anomalies. Female babies are particularly vulnerable to the negative impact of arsenic exposure, with a higher risk of low weight for gestational age and congenital cardiac anomalies. Therefore, it is crucial to monitor and regulate the levels of arsenic in drinking water and food sources to prevent these adverse health outcomes. Further research is necessary to fully understand the impact of arsenic exposure on human health, especially during pregnancy and infancy, by implementing preventative measures and monitoring the levels of arsenic in the environment.

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Section: Reviewmentioning

confidence: 99%

Maternal Exposure to Arsenic and Its Impact on Maternal and Fetal Health: A Review

Ortiz-Garcia,

Cipriano Ramírez,

Juarez

et al. 2023

Cureus

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“…Ten additional studies were also evaluated but did not fulfil the inclusion criteria and were accordingly not considered further (Fleisch et al, 2022 ; Lampron‐Goulet et al, 2017 ; Mondal et al, 2020 ; Ourshalimian et al, 2019 ; Park et al, 2016 ; Paul et al, 2019 ; Su et al, 2012 ; Tinkelman et al, 2020 ; Wang, Mukherjee, et al, 2020 ; Zhou, Zhao, & Huang, 2022 ).…”

Section: Assessmentmentioning

confidence: 99%

Update of the risk assessment of inorganic arsenic in food

Schrenk,

Bignami,

Bodin

et al. 2024

EFS2

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The European Commission asked EFSA to update its 2009 risk assessment on arsenic in food carrying out a hazard assessment of inorganic arsenic (iAs) and using the revised exposure assessment issued by EFSA in 2021. Epidemiological studies show that the chronic intake of iAs via diet and/or drinking water is associated with increased risk of several adverse outcomes including cancers of the skin, bladder and lung. The CONTAM Panel used the benchmark dose lower confidence limit based on a benchmark response (BMR) of 5% (relative increase of the background incidence after adjustment for confounders, BMDL05) of 0.06 μg iAs/kg bw per day obtained from a study on skin cancer as a Reference Point (RP). Inorganic As is a genotoxic carcinogen with additional epigenetic effects and the CONTAM Panel applied a margin of exposure (MOE) approach for the risk characterisation. In adults, the MOEs are low (range between 2 and 0.4 for mean consumers and between 0.9 and 0.2 at the 95th percentile exposure, respectively) and as such raise a health concern despite the uncertainties.

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“…Although arsenic (As) has been reported to be one of the environmental factors contributing to the increased risk of GDM, − information on the relationship between arsenic species and GDM is very limited. Determining the concentrations of arsenic species in the biospecimen is vital because the toxicity of arsenic species varies greatly. − A small number of epidemiologic studies with varied assessment designs and methods have shown inconsistent results. − The effect of specific arsenic species on GDM is not well understood.…”

Section: Introductionmentioning

confidence: 99%

Association between Arsenic Methylation in Early Pregnancy and Gestational Diabetes Mellitus: A Prospective Cohort Study

Jiang,

Ma,

Zheng

et al. 2023

Environ. Health

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The metabolism of arsenic (As) plays a crucial role in its health effects. However, the impact of arsenic methylation during early pregnancy on gestational diabetes mellitus (GDM) remains unclear. This study aimed to investigate the associations between As methylation in the first and second trimesters and the incidence of GDM by conducting a prospective cohort study in Chongqing, China. Urine samples from first (n = 131) and second (n = 53) trimester pregnant women were analyzed for arsenite (As III ), arsenate (As V ), monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA) concentrations. Logistic regressions assessed associations between the concentrations of As species, methylation indices, and GDM risk. As species concentrations showed no significant differences between GDM and non-GDM groups. Higher MMA% (OR = 1.11; 95% CI = 1.02, 1.22) and lower secondary methylation index (SMI) (OR = 0.81; 95% CI = 0.71, 0.93) correlated with GDM risk, primarily in the first trimester. MMA% decreased and DMA% and SMI increased from the first to the second trimester. Results of stratified analyses revealed these associations in women under 28 or with normal BMIs (18−24 kg/m 2 ). The study underscores inefficient arsenic methylation as a GDM risk, modified by age and BMI, with the first trimester as a critical period.

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Arsenic exposure during pregnancy and postpartum maternal glucose tolerance: evidence from Bangladesh

Cited by 11 publications

References 48 publications

Maternal Exposure to Arsenic and Its Impact on Maternal and Fetal Health: A Review

Maternal Exposure to Arsenic and Its Impact on Maternal and Fetal Health: A Review

Update of the risk assessment of inorganic arsenic in food

Association between Arsenic Methylation in Early Pregnancy and Gestational Diabetes Mellitus: A Prospective Cohort Study

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