Arsenic exposure and serum antibody concentrations to diphtheria and tetanus toxoid in children at age 5: A prospective birth cohort in Bangladesh

Welch, Barrett M.; Branscum, Adam J.; Ahmed, Sharia M.; Hystad, Perry; Smit, Ellen; Afroz, Sakila; Megowan, Meghan; Mostofa, Golam; Hasan, Omar Sharif Ibne; Rahman, Mohammad L.; Quamruzzaman, Quazi; Christiani, David C.; Kile, Molly L.

doi:10.1016/j.envint.2019.04.015

Cited by 19 publications

(20 citation statements)

References 51 publications

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“…The study population was part of a prospective birth cohort recruited in the Munshiganj and Pabna districts of Bangladesh that has been described in detail elsewhere [3,10,43]. Briefly, pregnant women were recruited to examine associations between chronic arsenic exposure and pregnancy-related outcomes [43].…”

Section: Study Populationmentioning

confidence: 99%

“…The second follow up visit occurred when the children were aged 4-5 years old to investigate the effect of arsenic and other metals on immune functioning. Details of cohort follow-up procedures and loss to follow-up have been described in detail elsewhere [10].…”

Section: Study Populationmentioning

confidence: 99%

“…A single value of W-Mn was below the LOD measured during early childhood. Final concentrations of W-As and W-Mn were calculated consistently to our previous study of W-As [10], whereby measurements taken during consecutive study visits were averaged to represent pregnancy, toddlerhood, and early childhood study periods. Between each pair of consecutive study visits, a child was assigned the average value if concentrations were available, or the single non-missing value if only one time period was available.…”

Section: Environmental and Biomarker Metal Measurementsmentioning

confidence: 99%

“…Diphtheria and tetanus toxoids are both classic protein antigens that rely on Thelper cells for primary and recall antibody-mediated responses [45,46]. Blood samples provided by children were used to quantify concentrations of diphtheria and tetanus antibody as described in detail elsewhere [10]. Briefly, 2 mL of venous blood was collected in vacutainers and allowed to clot at room temperature.…”

Section: Vaccine Antibody Measurementsmentioning

confidence: 99%

“…Prospective cohort studies report that arsenic exposure increases infectious disease risk in the first year of life [8]. Additionally, prenatal and early childhood arsenic exposure is associated with suppressed cell-mediated immunity and modulation of humoral immunity via altered immunoglobulin (Ig) profiles [9][10][11][12]. Manganese plays an important role in nutritional immunity as it is sequestered cellularly to respond to infection [13].…”

Section: Introductionmentioning

confidence: 99%

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Evaluating the effects between metal mixtures and serum vaccine antibody concentrations in children: a prospective birth cohort study

et al. 2020

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Background: Many populations are exposed to arsenic, lead, and manganese. These metals influence immune function. We evaluated the association between exposure to single and multiple metals, including arsenic, lead, and manganese, to humoral immunity as measured by antibody concentrations to diphtheria and tetanus toxoid among vaccinated Bangladeshi children. Additionally, we examined if this association was potentially mediated by nutritional status. Methods: Antibody concentrations to diphtheria and tetanus were measured in children's serum at age 5 (n = 502). Household drinking water was sampled to quantify arsenic (W-As) and manganese (W-Mn), whereas lead was measured in blood (B-Pb). Exposure samples were taken during pregnancy, toddlerhood, and early childhood. Multiple linear regression models (MLRs) with single or combined metal predictors were used to determine the association with antibody outcomes. MLR results were transformed to units of percent change in outcome per doubling of exposure to improve interpretability. Structural equation models (SEMs) were used to further assess exposure to metal mixtures. SEMs regressed a latent exposure variable (Metals), informed by all measured metal variables (W-As, W-Mn, and B-Pb), on a latent outcome variable (Antibody), informed by measured antibody variables (diphtheria and tetanus). Weight-forage z-score (WFA) at age 5 was evaluated as a mediator.

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Section: Study Populationmentioning

confidence: 99%

Section: Study Populationmentioning

confidence: 99%

Section: Environmental and Biomarker Metal Measurementsmentioning

confidence: 99%

Section: Vaccine Antibody Measurementsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluating the effects between metal mixtures and serum vaccine antibody concentrations in children: a prospective birth cohort study

et al. 2020

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Provision of folic acid for reducing arsenic toxicity in arsenic-exposed children and adults

Bae

Kamynina

Guetterman

et al. 2021

Cochrane Database of Systematic Reviews

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Arsenic in the water and agricultural crop production system: Bangladesh perspectives

Sandhi

Rahman³

et al. 2022

Environ Sci Pollut Res

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The presence of high levels of carcinogenic metalloid arsenic (As) in the groundwater system of Bangladesh has been considered as one of the major environmental disasters in this region. Many parts of Bangladesh have extensively reported the presence of high levels of arsenic in the groundwater due to both geological and anthropogenic activities. In this paper, we reviewed the available literature and scientific information regarding arsenic pollution in Bangladesh, including arsenic chemistry and occurrences. Along with using As-rich groundwater as a drinking-water source, the agricultural activities and especially irrigation have greatly depended on the groundwater resources in this region due to high water demands for ensuring food security. A number of investigations in Bangladesh have shown that high arsenic content in both soil and groundwater may result in high levels of arsenic accumulation in different plants, including cereals and vegetables. This review provides information regarding arsenic accumulation in major rice varieties, soil-groundwater-rice arsenic interaction, and past arsenic policies and plans, as well as previously implemented arsenic mitigation options for both drinking and irrigation water systems in Bangladesh. In conclusion, this review highlights the importance and necessity for more in-depth studies as well as more effective arsenic mitigation action plans to reduce arsenic incorporation in the food chain of Bangladesh.

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Arsenic exposure and serum antibody concentrations to diphtheria and tetanus toxoid in children at age 5: A prospective birth cohort in Bangladesh

Cited by 19 publications

References 51 publications

Evaluating the effects between metal mixtures and serum vaccine antibody concentrations in children: a prospective birth cohort study

Evaluating the effects between metal mixtures and serum vaccine antibody concentrations in children: a prospective birth cohort study

Provision of folic acid for reducing arsenic toxicity in arsenic-exposed children and adults

Arsenic in the water and agricultural crop production system: Bangladesh perspectives

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