Arsenic: an ancient toxicant of continuous public health impact, from Iceman Ötzi until now

Bolt, Hermann M.

doi:10.1007/s00204-012-0866-7

Cited by 51 publications

(21 citation statements)

References 59 publications

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“…The oldest case of environmental toxicity is scientifically attested by hair analysis of the Tyrolean Neolithic mummy "Ötzi," who died between 3359 and 3105 BC (Bolt 2012). Ötzi suffered from chronic arsenic exposure, probably because of his long-term involvement in copper working.…”

mentioning

confidence: 99%

Monocrotophos in Gandaman village: India school lunch deaths and need for improved toxicity testing

et al. 2013

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mentioning

confidence: 99%

Monocrotophos in Gandaman village: India school lunch deaths and need for improved toxicity testing

et al. 2013

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“…Another highly relevant cause of human urothelial cancer, for which combination effects with other toxicants are of scientific concern, is arsenic (Golka et al 2010;Bolt 2012Bolt , 2013. In a recent review, Bustaffa et al (2014) have summarised the genetic and epigenetic mechanisms in arsenic carcinogenicity.…”

Section: ) and Tobacco Smokementioning

confidence: 99%

Causation of human urothelial cancer: there are challenging new data!

Bolt

2014

Arch Toxicol

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“…Long-term exposure to arsenic is causally related to a variety of dermal symptoms (arsenicosis), peripheral neuropathy, encephalopathy, bronchitis, pulmonary fibrosis, hepato-splenomegaly, hypertension, peripheral vascular disease, atherosclerosis, cancer (lung, bladder, other organs) and diabetes mellitus (Bolt, 2012). WHO and European Union have set an upper limit of 10 µg/l arsenic in drinking water (Zhao, 2010).…”

Section: Hazardmentioning

confidence: 99%

A foresight study on emerging technologies: State of the art of Omics technologies and potential applications in food and feed safety

Pielaat

Barker

Hendriksen

et al. 2013

EFSA Supporting Publications

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Suggested citation: Pielaat A, Barker GC, Hendriksen P, Peijnenburg A and Kuile BH, 2013. A foresight study on emerging technologies: State of the art of omics technologies and potential applications in food and feed safety. REPORT 1: Review on the state of art of omics technologies in risk assessment related to food and feed safety. EFSA supporting publication 2013:EN-495, 126 pp. ABSTRACTThis report consists of a review of the available scientific evidence on the state of art of omics technologies with a particular focus on applications in the area of food and feed safety. The report gives a description of the different types of omics technologies with respect to recent progresses made on the application of these techniques in chemical and microbiological risk assessment. Hereto, case studies were selected in order to cover different areas under the remit of EFSA. In this review each case study has been investigated with respect to its hazard, experimental methodologies, (statistical) data analysis and its link to food/feed safety risk assessment. Finally, the added value of omics technologies as compared to classical risk assessment and current limitations of omics technologies for their application in chemical and microbiological food safety risk assessment has been discussed. This investigation shows that most of the studies on chemical agents focus on mode of action identification and a search for biomarkers using transcriptomics. As for microbial food safety, omics have not yet been successfully applied often. When applied, they never target the host, but focus on aspects of the pathogen, e.g. in detection or source attribution.

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Arsenic: an ancient toxicant of continuous public health impact, from Iceman Ötzi until now

Cited by 51 publications

References 59 publications

Monocrotophos in Gandaman village: India school lunch deaths and need for improved toxicity testing

Monocrotophos in Gandaman village: India school lunch deaths and need for improved toxicity testing

Causation of human urothelial cancer: there are challenging new data!

A foresight study on emerging technologies: State of the art of Omics technologies and potential applications in food and feed safety

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