Arrhythmogenic Mitral Valve Prolapse

Korovesis, Theofanis George; Koutrolou-Sotiropoulou, Paraskevi; Katritsis, Demosthenes G.

doi:10.15420/aer.2021.28

Cited by 7 publications

(2 citation statements)

References 56 publications

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“…Pathological contraction and distortion of the contraction may exert excessive traction on the papillary muscle, thus inducing fibrosis. These fibrotic changes, friction lesions, and myocardial stretching can lead to VAs either through reentry or triggered activity [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

The Association Between Late Gadolinium Enhancement by Cardiac Magnetic Resonance and Ventricular Arrhythmia in Patients With Mitral Valve Prolapse: A Systematic Review and Meta‐Analysis

Tang,

Fan

2024

Clinical Cardiology

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IntroductionMalignant ventricular arrhythmia (VA) and sudden cardiac death (SCD) have been reported in patients with mitral valve prolapse (MVP); however, effective risk stratification methods are still lacking. Myocardial fibrosis is thought to play an important role in the development of VA; however, observational studies have produced contradictory findings regarding the relationship between VA and late gadolinium enhancement (LGE) in MVP patients. The aim of this meta‐analysis and systematic review of observational studies was to investigate the association between left ventricular LGE and VA in patients with MVP.MethodsWe searched the PubMed, Embase, and Web of Science databases from 1993 to 2023 to identify case–control, cross‐sectional, and cohort studies that compared the incidence of VA in patients with MVP who had left ventricular LGE and those without left ventricular LGE.ResultsA total of 1464 subjects with MVP from 12 observational studies met the eligibility criteria. Among them, VA episodes were reported in 221 individuals (15.1%). Meta‐analysis demonstrated that the presence of left ventricular LGE was significantly associated with an increased risk of VA (pooled risk ratio 2.96, 95% CI: 2.26−3.88, p for heterogeneity = 0.07, I2 = 40%). However, a meta‐regression analysis of the prevalence of mitral regurgitation (MR) showed that the severity of MR did not significantly affect the association between the occurrence of LGE and VA (p = 0.079).ConclusionThe detection of LGE could be helpful for stratifying the risk of VA in patients with MVP.

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Section: Discussionmentioning

confidence: 99%

The Association Between Late Gadolinium Enhancement by Cardiac Magnetic Resonance and Ventricular Arrhythmia in Patients With Mitral Valve Prolapse: A Systematic Review and Meta‐Analysis

Tang,

Fan

2024

Clinical Cardiology

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“…The severity of MR does not appear to be linked to the arrhythmias burden [ 50 ]. MVP-related VT appears to manifest with greater frequency in females, although the precise cause for this divergence remains unclear and may be multifactorial [ 51 ].…”

Section: Introductionmentioning

confidence: 99%

Arrhythmic Mitral Valve Prolapse: A Comprehensive Review

Deng,

Liu,

et al. 2023

Diagnostics

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Mitral valve prolapse (MVP) is a prevalent cardiac disorder that impacts approximately 2% to 3% of the overall population. While most patients experience a benign clinical course, there is evidence suggesting that a subgroup of MVP patients face an increased risk of sudden cardiac death (SCD). Although a conclusive causal link between MVP and SCD remains to be firmly established, various factors have been associated with arrhythmic mitral valve prolapse (AMVP). This study aims to provide a comprehensive review encompassing the historical background, epidemiology, pathology, clinical manifestations, electrocardiogram (ECG) findings, and treatment of AMVP patients. A key focus is on utilizing multimodal imaging techniques to accurately diagnose AMVP and to highlight the role of mitral annular disjunction (MAD) in AMVP.

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Arrhythmogenic Mitral Valve Prolapse: Can We Risk Stratify and Prevent Sudden Cardiac Death?

Cameron,

Kadhim,

Kamsani

et al. 2024

Arrhythm Electrophysiol Rev

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Ventricular arrhythmias associated with mitral valve prolapse (MVP) and the capacity to cause sudden cardiac death (SCD), referred to as ‘malignant MVP’, are an increasingly recognised, albeit rare, phenomenon. SCD can occur without significant mitral regurgitation, implying an interaction between mechanical derangements affecting the mitral valve apparatus and left ventricle. Risk stratification of these arrhythmias is an important clinical and public health issue to provide precise and targeted management. Evaluation requires patient and family history, physical examination and electrophysiological and imaging-based modalities. We provide a review of arrhythmogenic MVP, exploring its epidemiology, demographics, clinical presentation, mechanisms linking MVP to SCD, markers of disease severity, testing modalities and management, and discuss the importance of risk stratification. Even with recently improved understanding, it remains challenging how best to weight the prognostic importance of clinical, imaging and electrophysiological data to determine a clear high-risk arrhythmogenic profile in which an ICD should be used for the primary prevention of SCD.

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Arrhythmogenic Mitral Valve Prolapse

Cited by 7 publications

References 56 publications

The Association Between Late Gadolinium Enhancement by Cardiac Magnetic Resonance and Ventricular Arrhythmia in Patients With Mitral Valve Prolapse: A Systematic Review and Meta‐Analysis

The Association Between Late Gadolinium Enhancement by Cardiac Magnetic Resonance and Ventricular Arrhythmia in Patients With Mitral Valve Prolapse: A Systematic Review and Meta‐Analysis

Arrhythmic Mitral Valve Prolapse: A Comprehensive Review

Arrhythmogenic Mitral Valve Prolapse: Can We Risk Stratify and Prevent Sudden Cardiac Death?

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