Arrhythmogenesis in a Novel Murine Model with KCNJ2 Mutation of Familial Atrial Fibrillation

Musa, Hassan; Carlton, Lisa D.; Klos, Matthew; Vikstrom, Karen L.; Anumonwo, Justus M.B.; Jalife, José; Berenfeld, Omer

doi:10.1016/j.hrthm.2013.09.077

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“…In a seminal study, the expression of miR-1 was demonstrated to be reduced by ~86% in tissue samples of AF patients (Girmatsion et al, 2009 ). This miR has been shown to be mechanistically critical in the pathophysiology of AF via targeting I K1 and connexin43 (Girmatsion et al, 2009 ), both considered master regulators of cardiac conduction (Delmar and Makita, 2012 ; Musa et al, 2013 ). Similarly, miR-26 has the potential to repress I K1 (Luo et al, 2013 ).…”

Section: Regulation Of Proteins Involved In Electrical Remodeling By mentioning

confidence: 99%

Atrial fibrillation and microRNAs

et al. 2014

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Atrial fibrillation (AF) is the most common sustained arrhythmia, especially in the elderly, and has a significant genetic component. Recently, several independent investigators have demonstrated a functional role for small non-coding RNAs (microRNAs) in the pathophysiology of this cardiac arrhythmia. This report represents a systematic and updated appraisal of the main studies that established a mechanistic association between specific microRNAs and AF, focusing both on the regulation of electrical and structural remodeling of cardiac tissue.

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