Arrhythmia susceptibility in a rat model of acute atrial dilation

Scardigli, Marina; Cannazzaro, Samantha; Coppini, Raffaele; Crocini, Claudia; Yan, Ping; Loew, Leslie M.; Sartiani, Laura; Cerbai, Elisabetta; Pavone, Francesco S.; Sacconi, Leonardo; Ferrantini, Cecilia

doi:10.1016/j.pbiomolbio.2019.08.012

Cited by 5 publications

(2 citation statements)

References 46 publications

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“…The incidence and prevalence of atrial fibrillation are increasing each year, and this condition is one of the most common clinical arrhythmias[ 1 , 2 ]. Atrial fibrillation leads to stroke, thromboembolic events, heart failure, myocardial infarction, and cognitive decline, as well as an increased risk of chronic kidney disease and other diseases[ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Significance of serum fibroblast growth factor-23 and miR-208b in pathogenesis of atrial fibrillation and their relationship with prognosis

Chen¹,

Zhong²,

Tu³

et al. 2020

WJCC

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BACKGROUND The incidence and prevalence of atrial fibrillation are increasing each year, and this condition is one of the most common clinical arrhythmias. AIM To investigate the levels and significance of serum fibroblast growth factor 23 (FGF-23) and miR-208b in patients with atrial fibrillation and their relationship with prognosis. METHODS From May 2018 to October 2019, 240 patients with atrial fibrillation were selected as an observation group, including 134 with paroxysmal atrial fibrillation and 106 with persistent atrial fibrillation; 150 patients with healthy sinus rhythm were selected as a control group. The serum levels of FGF-23 and miR-208b in the two groups were measured. In the observation group, cardiac parameters were determined by echocardiography. RESULTS The serum levels of FGF-23 and miR-208b in the observation group were 210.20 ± 89.60 ng/mL and 5.30 ± 1.22 ng/mL, which were significantly higher than the corresponding values in the control group ( P < 0.05). In the observation group, the serum levels of FGF-23 and miR-208b in patients with persistent atrial fibrillation were 234.22 ± 70.05 ng/mL and 5.83 ± 1.00 ng/mL, which were significantly higher than the corresponding values in patients with paroxysmal atrial fibrillation ( P < 0.05). The left atrial dimension (LAD) of patients with persistent atrial fibrillation was 38.81 ± 5.11 mm, which was significantly higher than that of patients with paroxysmal atrial fibrillation ( P > 0.05). The serum levels of FGF-23 and miR-208b were positively correlated with the LAD ( r = 0.411 and 0.382, P < 0.05). In the observation group, the serum levels of FGF-23 and miR-208b in patients with a major cardiovascular event (MACE) were 243.30 ± 72.29 ng/mL and 6.12 ± 1.12 ng/mL, which were significantly higher than the corresponding values in patients without a MACE ( P < 0.05). CONCLUSION The serum levels of FGF-23 and miR-208b are increased in patients with atrial fibrillation and are related to the type of disease, cardiac parameters, and prognosis.

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Section: Introductionmentioning

confidence: 99%

Significance of serum fibroblast growth factor-23 and miR-208b in pathogenesis of atrial fibrillation and their relationship with prognosis

Chen¹,

Zhong²,

Tu³

et al. 2020

WJCC

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show abstract

“…Moreover, cerebral ischemia, stroke, myocardial ischemia, and myocardial infarction are associated with increased risk of higher excitability resulting in seizures, epilepsy, and life-threatening arrhythmias [ 63 , 64 , 65 ]. Furthermore, the pathological stretch in heart failure and valvular heart disease is associated with serious arrhythmias such as ventricular tachycardia, ventricular fibrillation, and atrial fibrillation [ 66 , 67 , 68 , 69 ]. So, the decrease in the gating free energy can increase the risk of developing excitability-related disorders.…”

Section: Discussionmentioning

confidence: 99%

Mathematical Modeling of Ion Quantum Tunneling Reveals Novel Properties of Voltage-Gated Channels and Quantum Aspects of Their Pathophysiology in Excitability-Related Disorders

et al. 2021

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Voltage-gated channels are crucial in action potential initiation and propagation and there are many diseases and disorders related to them. Additionally, the classical mechanics are the main mechanics used to describe the function of the voltage-gated channels and their related abnormalities. However, the quantum mechanics should be considered to unravel new aspects in the voltage-gated channels and resolve the problems and challenges that classical mechanics cannot solve. In the present study, the aim is to mathematically show that quantum mechanics can exhibit a powerful tendency to unveil novel electrical features in voltage-gated channels and be used as a promising tool to solve the problems and challenges in the pathophysiology of excitability-related diseases. The model of quantum tunneling of ions through the intracellular hydrophobic gate is used to evaluate the influence of membrane potential and gating free energy on the tunneling probability, single channel conductance, and quantum membrane conductance. This evaluation is mainly based on graphing the mathematical relationships between these variables. The obtained mathematical graphs showed that ions can achieve significant quantum membrane conductance, which can affect the resting membrane potential and the excitability of cells. In the present work, quantum mechanics reveals original electrical properties associated with voltage-gated channels and introduces new insights and implications into the pathophysiology of excitability- related disorders. In addition, the present work sets a mathematical and theoretical framework that can be utilized to conduct experimental studies in order to explore the quantum aspects of voltage-gated channels and the quantum bioelectrical property of biological membranes.

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Whole-cell patch-clamp recording and parameters

Kodirov

2023

Biophys Rev

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Arrhythmia susceptibility in a rat model of acute atrial dilation

Cited by 5 publications

References 46 publications

Significance of serum fibroblast growth factor-23 and miR-208b in pathogenesis of atrial fibrillation and their relationship with prognosis

Significance of serum fibroblast growth factor-23 and miR-208b in pathogenesis of atrial fibrillation and their relationship with prognosis

Mathematical Modeling of Ion Quantum Tunneling Reveals Novel Properties of Voltage-Gated Channels and Quantum Aspects of Their Pathophysiology in Excitability-Related Disorders

Whole-cell patch-clamp recording and parameters

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