Arrhythmia and thyroid dysfunction

Marrakchi, S.; Kanoun, F.; Idriss, Salim F.; Kammoun, Ikram; Kachboura, Salem

doi:10.1007/s00059-014-4123-0

Cited by 41 publications

(33 citation statements)

References 83 publications

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“…Thyroid hormone plays an important role in cardiac muscle, systemic circulation, and the sympathetic nervous system that affect cardiovascular hemodynamics. The action of thyroid hormone is mediated by the binding of T 3 to nuclear receptors [2] . The subsequent binding of the T 3 -receptor complex to DNA regulates the expression of genes coding for cardiac proteins, such as sarcoplasmic reticulum calcium adenosine triphosphatase, myosin heavy chain-α, β 1 -adrenergic receptors, guanine nucleotide-regulatory proteins, sodium/potassium adenosine triphosphatase, and voltage-gated potassium channels [7] .…”

Section: Discussionmentioning

confidence: 99%

“…Genomic and nongenomic actions of thyroid hormone may contribute to paroxysmal atrial tachycardia, atrial fibrillation (AF), and atrial flutter. Among these arrhythmias, AF is the most common, occurring in 9-22% of patients with hyperthyroidism [2] . Complications of AF in patients with hyperthyroidism include heart failure and thrombus formation, which can be life threatening [3] .…”

Section: Introductionmentioning

confidence: 99%

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Unusual Manifestation of Graves' Disease: Ventricular Fibrillation

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Unusual Manifestation of Graves' Disease: Ventricular Fibrillation

et al. 2015

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“…Some clinical studies also suggest increased risk for arrhythmias in subclinical hypothyroidism [12,13]. This issue certainly merits clarification since the current fear of arrhythmia induction with TH treatment of HF may actually be leading to more arrhythmias in some cases.…”

Section: Editorialmentioning

confidence: 99%

Is There A Safe, Therapeutic Window for Thyroid Hormone Therapy in Heart Failure?

A¹

2017

Thyroid Disorders Ther

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“…Hyperthyroidism is a well known risk factor for atrial fibrillation [10,11]. Hypothyroidism has also been reported to increase ventricular arrhythmias [12]. Hypothyroidism decreases myocyte-specific gene expression in the heart and changes the cardiac function [13].…”

Section: Ijomeh 2016;29(4)mentioning

confidence: 99%

Military jet pilots have higher p-wave dispersions compared to the transport aircraft aircrew

Çakar

Metin

Balta

et al. 2016

Int J Occup Med Environ Health

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Objectives: For the purpose of flight safety military aircrew must be healthy. P-wave dispersion (PWD) is the p-wave length difference in an electrocardiographic (ECG) examination and represents the risk of developing atrial fibrillation. In the study we aimed at investigating PWD in healthy military aircrew who reported for periodical examinations. Material and Methods: Seventy-five asymptomatic military aircrew were enrolled in the study. All the subjects underwent physical, radiologic and biochemical examinations, and a 12-lead electrocardiography. P-wave dispersions were calculated. Results: The mean age of the study participants was 36.15±8.97 years and the mean p-wave duration was 100.8±12 ms in the whole group. Forty-seven subjects were non-pilot aircrew, and 28 were pilots. Thirteen study subjects were serving in jets, 49 in helicopters, and 13 were transport aircraft pilots. Thirty-six of the helicopter and 11 of the transport aircraft aircrew were non-pilot aircrew. P-wave dispersion was the lowest in the transport aircraft aircrew, and the highest in jet pilots. P-wave dispersions were similar in the pilots and non-pilot aircrew. Twenty-three study subjects were overweight, 19 had thyroiditis, 26 had hepatosteatosis, 4 had hyperbilirubinemia, 2 had hypertension, and 5 had hyperlipidemia. The PWD was significantly associated with thyroid-stimulating hormone (TSH) levels. Serum uric acid levels were associated with p-wave durations. Serum TSH levels were the most important predictor of PWD. Conclusions: When TSH levels were associated with PWD, uric acid levels were associated with p-wave duration in the military aircrew. The jet pilots had higher PWDs. These findings reveal that military jet pilots may have a higher risk of developing atrial fibrillation, and PWD should be recorded during periodical examinations. MATERIAL AND METHODS SubjectsThe study was conducted in a secondary military referral health center. Our hospital is also a center for the yearly and 5-year periodical examinations of military aircrew. A total of 75 military aircrew, all of whom were male, reporting for 5-year periodical examinations were enrolled in the study. Military non-pilot aircrew are people helping with search-rescue jobs, transporting objects, carrying goods needed for the flight, etc., who fly with pilots together in helicopters and in transport aircrafts. Physical examination, blood pressure (BP) and anthropometric measurements were performed as part of the 5-year periodical examinations. The examinations also included obtaining information on the type of the aircraft they serve in, their tasks, drug history, smoking, alcohol usage and past medical history. Complete blood count, renal and hepatic function tests, electrolytes, serum lipid levels, thyroid hormones, serum thyroid antibodies, electrocardiographic and echocardiographic examinations were also performed within the examinations. Exclusion criteria for the study participants were: refusal to participate in the study, smoking, uncontrolled hypertensi...

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Arrhythmia and thyroid dysfunction

Abstract: The early recognition and effective treatment of thyroid dysfunction in patients with arrhythmia is mandatory because the long-term prognosis of arrhythmia may be improved with the appropriate treatment of thyroid dysfunction.

Cited by 41 publications

References 83 publications

Unusual Manifestation of Graves' Disease: Ventricular Fibrillation

Unusual Manifestation of Graves' Disease: Ventricular Fibrillation

Is There A Safe, Therapeutic Window for Thyroid Hormone Therapy in Heart Failure?

Military jet pilots have higher p-wave dispersions compared to the transport aircraft aircrew

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