Aromatic-turmerone ameliorates DSS-induced ulcerative colitis via modulating gut microbiota in mice

Li, Chunlian; Zhang, Weicheng; Wu, Xianyi; Cai, Qiuyang; Tan, Zekai; Hong, Zhengyi; Huang, Shiyuan; Yuan, Yanghe; Yao, Lewen; Zhang, Lanyue

doi:10.1007/s10787-022-01007-w

Cited by 9 publications

(5 citation statements)

References 39 publications

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“…It can also reduce the abundance of harmful bacteria such as Campylobacterota, Colstridia, Oscillospirales, Desulfovibria and Ruminococcaceae. These results are also consistent with previous studies [ 35 , 45 - 47 ].…”

Section: Discussionsupporting

confidence: 94%

Eucommia ulmoides polysaccharide modified nano-selenium effectively alleviated DSS-induced colitis through enhancing intestinal mucosal barrier function and antioxidant capacity

Guo

Huang

et al. 2023

J Nanobiotechnol

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Ulcerative colitis (UC) is currently the most common inflammatory bowel disease (IBD). Due to its diverse and complex causes, there is no cure at present, and researchers are constantly exploring new therapies. In recent years, nano-selenium particle(SeNP) has attracted wide attention due to excellent biological activities. Therefore, in this study, for the first time, we used a natural polysaccharide, Eucommia ulmoides polysaccharide (EUP), modified SeNP to get EUP-SeNP with a size of about 170 nm, and its effect on 3% dextran sulphate sodium (DSS) induced colitis was explored. Our results showed that colon intestinal histology, intestinal mucosal barrier, inflammatory cytokines and intestinal microbiome composition were changed after EUP-SeNP treatment in colitis mice. Specifically, it was also shown that oral treatment of EUP-SeNP could relieve the degree of DSS-induced colitis in mice by restoring weight loss, reducing disease activity index (DAI), enhancing colon antioxidant capacity and regulating intestinal microbiome composition. In addition, we verified the mechanism in intestinal epithelial cell lines, showing that EUP-SeNP inhibited LPS-induced activation of the TRL-4/NF-κB signaling pathway in intestinal epithelial cell lines. To some extend, our study provides therapeutic reference for the treatment of IBD.

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Section: Discussionsupporting

confidence: 94%

Eucommia ulmoides polysaccharide modified nano-selenium effectively alleviated DSS-induced colitis through enhancing intestinal mucosal barrier function and antioxidant capacity

Guo

Huang

et al. 2023

J Nanobiotechnol

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“…Aromatic turmeric ketone is effective in UC treatment; it prevents DSS-induced damage of the intestinal flora, maintains some beneficial bacteria, and reduces harmful bacteria. 60 A diet rich in n-6 unsaturated fatty acids (PUFA) increases the microbiota in mice, which induces inflammation and exacerbates infections causing colitis. However, the addition of n-3 PUFA to a diet rich in n-6 PUFA converts the pro-inflammatory microbiota to anti-inflammatory microbiota, thereby preventing colitis.…”

Section: Use Of Essential Oils In Uc Treatment and Its Complicationsmentioning

confidence: 99%

Therapeutic Potential of Essential Oils Against Ulcerative Colitis: A Review

Li,

Zhang,

Luan

et al. 2024

JIR

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Ulcerative colitis (UC) is a chronic non-sp ecific inflammatory disease of the colorectal mucosa. Researchers have associated UC onset with familial genetics, lifestyle behavior, inflammatory immune factors, intestinal microbiota, and the integrity of the intestinal mucosal barrier. The primary therapeutic interventions for UC consist of pharmacological management to control inflammation and promote mucosal healing and surgical interventions. The available drugs effectively control and decelerate the progression of UC in most patients; nonetheless, their long-term administration can exert adverse effects and influence the therapeutic effect. Plant essential oils (EOs) refer to a group of hydrophobic aromatic volatile substances. EOs have garnered considerable attention in both domestic and international research because of their anti-inflammatory, antibacterial, and antioxidant properties. They include peppermint, peppercorns, rosemary, and lavender, among others. Researchers have investigated the role of EOs in medicine and have elucidated their potential to mitigate the detrimental effects of UC through their anti-inflammatory, antioxidant, antidepressant, and anti-insomnia properties as well as their ability to regulate the intestinal flora. Furthermore, EOs exert minimal toxic adverse effects, further enhancing their appeal for therapeutic applications. However, these speculations are based on theoretical experiments, thereby warranting more clinical studies to confirm their effectiveness and safety. In this article, we aim to provide an overview of the advancements in utilizing natural medicine EOs for UC prevention and treatment. We will explore the potential pathogenesis of UC and examine the role of EOs therapy in basic research, quality stability, and management specification of inadequate EOs for UC treatment. We intend to offer novel insights into the use of EOs in UC prevention and management.

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“…Phenolic compounds exhibit potent anti-inflammatory and antioxidant activities in vitro and in vivo and are a major class of agents against IBD, mainly flavonoids, catechins, stilbenes, coumarins and phenolic acids [ 134 ]. Curcumin, a hydrophobic polyphenol extracted from the roots of turmeric, can protect mice against DSS-induced colitis by enhancing the abundance and stability of intestinal flora, upregulating the proportion of Ruminococcaceae , Lachnospiraceae , Muribaculaceae , and Prevotellaceae , and downregulating the relative abundance of Helicobacteraceae , Desulfouvibrionaceae and Marinifilaceae [ 117 ]. The beneficial effects of phytoflavonoids on the intestine are well established.…”

Section: Pharmacological Interventions For Ibd and Their Effects On G...mentioning

confidence: 99%

Manipulating Microbiota in Inflammatory Bowel Disease Treatment: Clinical and Natural Product Interventions Explored

Zhu

Song

et al. 2023

IJMS

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Inflammatory bowel disease (IBD) is a complex multifactorial chronic inflammatory disease, that includes Crohn’s disease (CD) and ulcerative colitis (UC), having progressively increasing global incidence. Disturbed intestinal flora has been highlighted as an important feature of IBD and offers promising strategies for IBD remedies. A brief overview of the variations occurring in intestinal flora during IBD is presented, and the role of the gut microbiota in intestinal barrier maintenance, immune and metabolic regulation, and the absorption and supply of nutrients is reviewed. More importantly, we review drug research on gut microbiota in the past ten years, including research on clinical and natural drugs, as well as adjuvant therapies, such as Fecal Microbiota Transplantation and probiotic supplements. We also summarize the interventions and mechanisms of these drugs on gut microbiota.

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Aromatic-turmerone ameliorates DSS-induced ulcerative colitis via modulating gut microbiota in mice

Cited by 9 publications

References 39 publications

Eucommia ulmoides polysaccharide modified nano-selenium effectively alleviated DSS-induced colitis through enhancing intestinal mucosal barrier function and antioxidant capacity

Eucommia ulmoides polysaccharide modified nano-selenium effectively alleviated DSS-induced colitis through enhancing intestinal mucosal barrier function and antioxidant capacity

Therapeutic Potential of Essential Oils Against Ulcerative Colitis: A Review

Manipulating Microbiota in Inflammatory Bowel Disease Treatment: Clinical and Natural Product Interventions Explored

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