Manipulating Microbiota in Inflammatory Bowel Disease Treatment: Clinical and Natural Product Interventions Explored

Zhu, Mengjie; Song, Yijie; Xu, Yu; Hong, Xu

doi:10.3390/ijms241311004

Cited by 11 publications

(9 citation statements)

References 174 publications

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“…Recent studies have highlighted the potential protective role of genus Akkermansia against colitis. Specifically, Akkermansia muciniphila, a resident of the human gut, has been observed to have beneficial effects on the intestinal barrier function and inflammatory responses. , It is pertinent to mention that certain botanical extracts have shown to increase the abundance of this particular bacteria, fortifying the gut barrier and potentially ameliorating symptoms of IBD. , Although our study witnessed a rise in the Duncaniella genus, future research could delve into the potential synergies or complementary impacts of Virofree on other advantageous genera, such as Akkermansia.…”

Section: Discussionmentioning

confidence: 81%

“…46,47 It is pertinent to mention that certain botanical extracts have shown to increase the abundance of this particular bacteria, fortifying the gut barrier and potentially ameliorating symptoms of IBD. 48,49 Although our study witnessed a rise in the Duncaniella genus, future research could delve into the potential synergies or complementary impacts of Virofree on other advantageous genera, such as Akkermansia.…”

Section: Discussionmentioning

confidence: 90%

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Virofree Associates with the Modulation of Gut Microbiomes and Alleviation of DSS-Induced IBD Symptoms in Mice

Lin,

Cheng,

Pan

2023

ACS Omega

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Inflammatory bowel disease (IBD) is a chronic, nonspecific inflammation of the intestines that primarily comprises Crohn's disease and ulcerative colitis. The incidence and prevalence of IBD have been increasing globally, highlighting the significance of research and prophylactic interventions. Virofree, a mixture of various botanical extracts (including grapes, cherries, olive leaves, marigolds, green tea, and others), has shown significant potential in disease prevention. This study examined the effects of Virofree on intestinal inflammation and the gut microbiota in mice using a dextran sulfate sodium (DSS)-induced model. The mice showed no adverse reactions when administered Virofree. Virofree administration reduced the disease activity index as indicated by amelioration of DSS-induced symptoms in the mice, including weight loss, diarrhea, and rectal bleeding. Regarding the gut microbiota, Virofree intervention modulated the DSS-induced decrease in gut microbial diversity; the Virofree group showed no increase in the phyla Proteobacteria or Verrucomicrobia while displaying an increase in the genus Duncaniella, bacteria that may have protective properties. These findings suggest that Virofree may have a direct or indirect impact on the composition of the gut microbiota and that it can alleviate the imbalance of the microbiome and intestinal inflammation caused by DSS treatment.

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 90%

Virofree Associates with the Modulation of Gut Microbiomes and Alleviation of DSS-Induced IBD Symptoms in Mice

Lin,

Cheng,

Pan

2023

ACS Omega

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“…In general, the intake of dietary nutrition regulates the composition and function of gut microbiota, affects the functioning of the intestinal barrier, and further mediates changes in intestinal metabolic status and immune response (Figure 2). In contrast, alterations of gut microbiota can also affect the availability and absorption of nutrients in the human body, impact the metabolic functions of the host, thereby accelerate the onset and progression of adverse states 102 …”

Section: Potential Contribution Of Gut Microbiota Modulation Related ...mentioning

confidence: 99%

“…It has been reported that a high‐fructose diet leads to a reduced abundance of genus Clostridium and decreased production of secondary BAs (especially LCA), which affects T helper 17 (Th17)/Treg cell equilibrium and promotes intestinal inflammation 107 . Notably, intestinal damage induced by microbiota dysbiosis reduces nutrient absorption capacity and further aggravates the immune and energy homeostasis imbalance 102 . In contrast to soluble sugars and refined carbohydrates, dietary fibers have many positive impacts on gut microbiota.…”

Section: Potential Contribution Of Gut Microbiota Modulation Related ...mentioning

confidence: 99%

Potential effects of nutrition‐induced alteration of gut microbiota on inflammatory bowel disease: A review

Tian,

Chen,

Xiao

et al. 2024

J of Digest Diseases

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Inflammatory bowel disease (IBD), mainly comprising ulcerative colitis and Crohn's disease, is a group of gradually progressive diseases bringing significant mental anguish and imposes serious economic burdens. Interplay of genetic, environmental, and immunological factors have been implicated in its pathogenesis. Nutrients, as crucial environmental determinants, mainly encompassing carbohydrates, fats, proteins, and micronutrients, are closely related to the pathogenesis and development of IBD. Nutrition is essential for maintaining the dynamic balance of intestinal eco‐environments to ensure intestinal barrier and immune homeostasis, while this balance can be disrupted easily by maladjusted nutrition. Research has firmly established that nutrition has the potential to shape the composition and function of gut microbiota to affect the disease course. Unhealthy diet and eating disorders lead to gut microbiota dysbiosis and further destroy the function of intestinal barrier such as the disruption of membrane integrity and increased permeability, thereby triggering intestinal inflammation. Notably, appropriate nutritional interventions, such as the Mediterranean diet, can positively modulate intestinal microecology, which may provide a promising strategy for future IBD prevention. In this review, we provide insights into the interplay between nutrition and gut microbiota and its effects on IBD and present some previously overlooked lines of evidence regarding the role of derived metabolites in IBD processes, such as trimethylamine N‐oxide and imidazole propionate. Furthermore, we provide some insights into reducing the risk of onset and exacerbation of IBD by modifying nutrition and discuss several outstanding challenges and opportunities for future study.

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“…Emerging from the abdomen, these fibers pass through the thorax and the neck to innervate the pharynx and larynx, and they ultimately reach the medulla oblongata, establishing the vagus nerve as a vital conduit for afferent signals. These signals, conveyed through the nucleus tractus solitarii (NTS), impact multiple cortical regions of the brain, such as the hypothalamus and amygdala, giving rise to a wide variety of nuanced responses that include emotional and behavioral reactions [ 68 , 69 ].…”

Section: The Gut–brain Axismentioning

confidence: 99%

Gut–Brain Interactions and Their Impact on Astrocytes in the Context of Multiple Sclerosis and Beyond

Zißler,

Rothhammer,

Linnerbauer

2024

Cells

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Multiple Sclerosis (MS) is a chronic autoimmune inflammatory disease of the central nervous system (CNS) that leads to physical and cognitive impairment in young adults. The increasing prevalence of MS underscores the critical need for innovative therapeutic approaches. Recent advances in neuroimmunology have highlighted the significant role of the gut microbiome in MS pathology, unveiling distinct alterations in patients’ gut microbiota. Dysbiosis not only impacts gut-intrinsic processes but also influences the production of bacterial metabolites and hormones, which can regulate processes in remote tissues, such as the CNS. Central to this paradigm is the gut–brain axis, a bidirectional communication network linking the gastrointestinal tract to the brain and spinal cord. Via specific routes, bacterial metabolites and hormones can influence CNS-resident cells and processes both directly and indirectly. Exploiting this axis, novel therapeutic interventions, including pro- and prebiotic treatments, have emerged as promising avenues with the aim of mitigating the severity of MS. This review delves into the complex interplay between the gut microbiome and the brain in the context of MS, summarizing current knowledge on the key signals of cross-organ crosstalk, routes of communication, and potential therapeutic relevance of the gut microbiome. Moreover, this review places particular emphasis on elucidating the influence of these interactions on astrocyte functions within the CNS, offering insights into their role in MS pathophysiology and potential therapeutic interventions.

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Manipulating Microbiota in Inflammatory Bowel Disease Treatment: Clinical and Natural Product Interventions Explored

Cited by 11 publications

References 174 publications

Virofree Associates with the Modulation of Gut Microbiomes and Alleviation of DSS-Induced IBD Symptoms in Mice

Virofree Associates with the Modulation of Gut Microbiomes and Alleviation of DSS-Induced IBD Symptoms in Mice

Potential effects of nutrition‐induced alteration of gut microbiota on inflammatory bowel disease: A review

Gut–Brain Interactions and Their Impact on Astrocytes in the Context of Multiple Sclerosis and Beyond

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