Aromatic sulfonyl hydrazides and sulfonyl hydrazones: antimicrobial activity and physical properties

Aslan, Halime Güzin; Karacan, Nurcan

doi:10.1007/s00044-012-0104-0

Cited by 20 publications

(11 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The hydrazones are a class of compounds cited as biologically valuable for pharmaceutical applications due to their antiinflammatory 20 , anticancer 21 , anti-tuberculosis 22 , anti-HIV 23 and anti-Alzheimer's disease (cholinesterase inhibitors) properties 24 . The literature also shows important antifungal properties of hydrazones [25][26][27] . In addition, the quinoline ring is also an important group in medicinal chemistry and has particular utility in antimalarial 28 , antituberculosis 29 , antileishmania 30 and antimicrobial 31 agents.…”

Section: Discussionmentioning

confidence: 99%

(7-Chloroquinolin-4-yl)arylhydrazones: Candida albicansenzymatic repression and cytotoxicity evaluation, Part 2

Carvalho

Duval

Leite

et al. 2015

Journal of Enzyme Inhibition and Medicinal Chemistry

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

(7-Chloroquinolin-4-yl)arylhydrazones: Candida albicansenzymatic repression and cytotoxicity evaluation, Part 2

Carvalho

Duval

Leite

et al. 2015

Journal of Enzyme Inhibition and Medicinal Chemistry

View full text Add to dashboard Cite

show abstract

“…The antimicrobial activity of all the synthesized compounds were screened in vitro for antibacterial and antifungal activities against two bacteria Staphylococcus aureus (gram ?ve) and Escherichia coli (gram -ve) and fungi Aspergillus niger and Aspergillus flavus at different concentrations 100, 50, 25, 12.5, 6.25, 3.12, 1.56 lg/ml by adopting disc diffusion method [27]. The compounds were dissolved in 10 % DMSO which was found to be biologically inactive.…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Eco Friendly Microwave Assisted Rapid and Efficient Synthesis, Spectroscopic Studies and Antimicrobial Activity of Bivalent Transition Metal Complexes of Hydrazones

Kumar

Singh

Neelam

et al. 2015

Proc. Natl. Acad. Sci., India, Sect. A Phys. Sci.

View full text Add to dashboard Cite

Two new series of Co(II), Ni(II) and Cu(II) metal complexes of the type [M(C 14 H 10 N 2 O 3 )Á2H 2 O] and [M(C 14 H 11 N 2 O 2 )Á3H 2 O]Ac, where M = Co(II)/Ni(II)/ Cu(II) and Ac = CH 3 COO -, have been synthesized in good yields at less reaction time by adopting an efficient and eco friendly microwave assisted method. All the synthesized compounds were characterized by running their TLC for single spot, HPLC, elemental analyses, IR, 1 H-NMR, 13 C-NMR, magnetic susceptibility measurements, electronic spectral studies and screened for antimicrobial activities against two bacteria Staphylococcus aureus (gram ?ve) and Escherichia coli (gram -ve) and fungi Aspergillus niger and Aspergillus flavus by adopting disc diffusion method. The antimicrobial activity results indicated that hydrazide exhibited good activity which increases in its hydrazones. However, the metal complexes exhibited maximum activity against both bacteria and fungi.

show abstract

“…The resulting substituted benzoxazines on hydrazinolysis gave the quinazolinone derivatives. The aminoquinazolinone derivatives were subjected to Hinsberg's reaction with substituted benzene DOI: 10.3109/14756366.2013.845820 sulfonylchloride [24][25][26] to yield the final compounds. The physicochemical data of all the synthesized compounds are recorded.…”

Section: Chemistrymentioning

confidence: 99%

Synthesis and characterization of quinazoline derivatives: search for hybrid molecule as diuretic and antihypertensive agents

Rahman

Rathore

Siddiqui

et al. 2013

Journal of Enzyme Inhibition and Medicinal Chemistry

View full text Add to dashboard Cite

To explore the pharmacological and structure-activity relationship of a series of N-substituted-(4-oxo-2-substituted-phenylquinazolin-3-(4H)-yl), substituted benzene sulfonamide derivatives (1-25) were synthesized from substituted anthranilic acids derived amino quinazolines and substituted benzene sulphonamides. All the synthesized compounds were evaluated for their diuretic (by Lipschitz et al. method), antihypertensive activity by non-invasive blood pressure (NIBP) using the tail-cuff method and anti-diabetic potential in rats. Six compounds showing significantly excellent activity were compared with metolazone, prazosin and diazoxide as standards. Compound N-[7-chloro-2-(4-methoxyphenyl)-4-oxoquinazolin-3(4H)-yl]-4 nitrobenzenesulfonamide (20) exhibited most potent of the series.

show abstract

Aromatic sulfonyl hydrazides and sulfonyl hydrazones: antimicrobial activity and physical properties

Cited by 20 publications

References 18 publications

(7-Chloroquinolin-4-yl)arylhydrazones: Candida albicansenzymatic repression and cytotoxicity evaluation, Part 2

(7-Chloroquinolin-4-yl)arylhydrazones: Candida albicansenzymatic repression and cytotoxicity evaluation, Part 2

Eco Friendly Microwave Assisted Rapid and Efficient Synthesis, Spectroscopic Studies and Antimicrobial Activity of Bivalent Transition Metal Complexes of Hydrazones

Synthesis and characterization of quinazoline derivatives: search for hybrid molecule as diuretic and antihypertensive agents

Contact Info

Product

Resources

About